Effect of FAM50 knockout on the transcriptome
|Study ID||Alternative Stable ID||Type|
A knockout clone has been generated for both FAM50A and FAM50B; knockout of the other gene is then performed and the transcriptome is analysed to look at the effect of dual gene loss.
Study Datasets 1 dataset.
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Genetic redundancy has evolved as a way for human cells to survive the loss of genes that are single copy and essential in other organisms, but also allows tumours to survive despite having highly rearranged genomes. In this study we CRISPR screen 1,191 gene pairs, including paralogues and known and predicted synthetic lethal interactions to identify 105 gene combinations whose co-disruption results in a loss of cellular fitness. 27 pairs influence fitness across multiple cell lines including ... (Show More)
|Illumina HiSeq 4000,Illumina NovaSeq 6000||55|
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