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The_evolution_of_CML

This project aims to investigate the timing of acquistion of key driver events in CML such as the canonical BCR/ABL gene fusion and their clonal trajectories in order determine selection advantage of such clones. Colonies derived from single haematopoietic progenitors will be sequenced as clonal units. This is in line with other work in the Nangalia lab and CASM.

Type: Other
Archive: European Genome-phenome Archive (EGA)

1 Dataset 2 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001015353	We sequence >1000 whole genomes from 9 patients with CML, providing the largest sequencing dataset for this cancer. We reconstruct phylogenetic trees using somatic mutations and infer BCR::ABL1 timing and tumour growth rates. We correlate mutation landscapes and clonal trajectories with clinical features.	Illumina NovaSeq 6000	-

Publications	Citations
Analysis of somatic mutations in whole blood from 200,618 individuals identifies pervasive positive selection and novel drivers of clonal hematopoiesis. Bernstein N, Spencer Chapman M, Nyamondo K, Chen Z, Williams N, Mitchell E, Campbell PJ, Cohen RL, Nangalia J. Nat Genet 56: 2024 1147-1155	88
Timing and trajectory of BCR::ABL1-driven chronic myeloid leukaemia. Kamizela AE, Leongamornlert D, Williams N, Wang X, Nyamondo K, Dawson K, Spencer Chapman M, Guo J, Lee J, Mane K, Milne K, Green AR, Chevassut T, Campbell PJ, Ellinor PT, Huntly BJP, Baxter EJ, Nangalia J. Nature 640: 2025 982-990	10