Timing the Philadelphia chromosome and trajectory to chronic myeloid leukaemia

We sequence >1000 whole genomes from 9 patients with CML, providing the largest sequencing dataset for this cancer. We reconstruct phylogenetic trees using somatic mutations and infer BCR::ABL1 timing and tumour growth rates. We correlate mutation landscapes and clonal trajectories with clinical features.

• 1 sample
• DAC: EGAC00001000000
• Technology: Illumina NovaSeq 6000