Whole genome sequencing of 76 tumor and normal samples from 11 SI-NET patients

We have sampled 11 patients with multifocal SI-NETs. The complete genome sequences of 65 tumor and tissue samples including 42 intestinal lesions, 14 adjacent lymph node metastases, 5 distant metastases, as well as of 4 normal tissue and 11 normal blood samples were determined. This allowed elucidation of phylogenetic relationships between tumors within individual patients.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001006161	This dataset comprises of 76 cancer and normal whole genomes obtained from 11 SI-NET patients, in the form of two fastq files (forward and reverse reads) for each genome containing sequences generated by Illumina NovaSeq 6000 system.	Illumina NovaSeq 6000	76

Publications	Citations
Independent somatic evolution underlies clustered neuroendocrine tumors in the human small intestine. Elias E, Ardalan A, Lindberg M, Reinsbach SE, Muth A, Nilsson O, Arvidsson Y, Larsson E. Nat Commun 12: 2021 6367	8