Study

The mutational landscape of primary central nervous system lymphoma (Hipo H050, A050, XD013)

Study ID Alternative Stable ID Type
EGAS00001005339 Other

Study Description

]Primary lymphomas of the central nervous system (PCNSL) are diffuse large B-cell lymphomas (DLBCLs) which are confined to the central nervous system (CNS). Despite extensive research, the molecular alterations leading to PCNSL have not been fully elucidated. In order to provide a comprehensive description of the mutational landscape in PCNSL, we here performed integrative whole genome and transcriptome sequencing analysis of 51 lymphomas presenting in the CNS, including 42 EBV-negative PCNSL, 6 secondary CNS lymphomas (SCNSL) and 3 EBV+ CNSL.

Study Datasets 4 datasets.

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Dataset ID Description Technology Samples
EGAD00001007806
26 Tumor/Control pairs of WGS data of PCNSL tumors, sequenced on either Illumina HiSeq2000/2500 instruments or HiSeq X Ten. The controls are blood or buffy coat samples in most cases.
HiSeq X Ten,Illumina HiSeq 2000,Illumina HiSeq 2500 52
EGAD00001007810
Paired WGS samples, 24 tumor/control pairs of primary CNS lymphoma, sequenced on HiSeq X Ten using Illumina TruSeq Nano DNA for library preparation.
HiSeq X Ten 24
EGAD00001007811
Primary lymphomas of the central nervous system (PCNSL) are diffuse large B-cell lymphomas (DLBCLs) which are confined to the central nervous system (CNS). Paired RNA-Seq sequencing was done on Illumina HiSeq2000 machines using Illumina TruSeq RNA library preparation kit. About 36 tumor samples were sequenced.
Illumina HiSeq 2000 38
EGAD00001008583
Sanger sequencing and RT-qPCR data for validation used in Primary lymphomas of the central nervous system (PCNSL).
1

Who archives the data?

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