Study
The mutational landscape of primary central nervous system lymphoma (Hipo H050, A050, XD013)
| Study ID | Alternative Stable ID | Type |
|---|---|---|
| EGAS00001005339 | Other |
Study Description
]Primary lymphomas of the central nervous system (PCNSL) are diffuse large B-cell lymphomas (DLBCLs) which are confined to the central nervous system (CNS). Despite extensive research, the molecular alterations leading to PCNSL have not been fully elucidated. In order to provide a comprehensive description of the mutational landscape in PCNSL, we here performed integrative whole genome and transcriptome sequencing analysis of 51 lymphomas presenting in the CNS, including 42 EBV-negative PCNSL, 6 secondary CNS lymphomas (SCNSL) and 3 EBV+ CNSL.
Study Datasets 4 datasets.
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
| Dataset ID | Description | Technology | Samples |
|---|---|---|---|
| EGAD00001007806 |
26 Tumor/Control pairs of WGS data of PCNSL tumors, sequenced on either Illumina HiSeq2000/2500 instruments or HiSeq X Ten. The controls are blood or buffy coat samples in most cases.
|
HiSeq X Ten,Illumina HiSeq 2000,Illumina HiSeq 2500 | 52 |
| EGAD00001007810 |
Paired WGS samples, 24 tumor/control pairs of primary CNS lymphoma, sequenced on HiSeq X Ten using Illumina TruSeq Nano DNA for library preparation.
|
HiSeq X Ten | 24 |
| EGAD00001007811 |
Primary lymphomas of the central nervous system (PCNSL) are diffuse large B-cell lymphomas (DLBCLs) which are confined to the central nervous system (CNS). Paired RNA-Seq sequencing was done on Illumina HiSeq2000 machines using Illumina TruSeq RNA library preparation kit. About 36 tumor samples were sequenced.
|
Illumina HiSeq 2000 | 38 |
| EGAD00001008583 |
Sanger sequencing and RT-qPCR data for validation used in Primary lymphomas of the central nervous system (PCNSL).
|
1 |
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