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The mutational landscape of primary central nervous system lymphoma (Hipo H050, A050, XD013)

]Primary lymphomas of the central nervous system (PCNSL) are diffuse large B-cell lymphomas (DLBCLs) which are confined to the central nervous system (CNS). Despite extensive research, the molecular alterations leading to PCNSL have not been fully elucidated. In order to provide a comprehensive description of the mutational landscape in PCNSL, we here performed integrative whole genome and transcriptome sequencing analysis of 51 lymphomas presenting in the CNS, including 42 EBV-negative PCNSL, 6 secondary CNS lymphomas (SCNSL) and 3 EBV+ CNSL.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001007806 HiSeq X Ten Illumina HiSeq 2000 Illumina HiSeq 2500 52
EGAD00001007810 HiSeq X Ten 24
EGAD00001007811 Illumina HiSeq 2000 38
EGAD00001008583 1
Publications Citations
The genomic and transcriptional landscape of primary central nervous system lymphoma.
Nat Commun 13: 2022 2558