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Single-cell RNA sequencing dissects gene-environment interactions on gene expression and regulation in immune cells.

This study aims to dissect gene-environment interactions on gene expression and regulation in immune cells using scRNA-seq data from 120 donors being stimulated with 3 pathogens, for 2 different timepoints. More specifically, we identified context- and cell-type-specific eQTLs and co-expression QTLs in PBMCs.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001007764 Illumina NovaSeq 6000 988
Publications Citations
Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals widespread, context-specific gene expression regulation upon pathogenic exposure.
Nat Commun 13: 2022 3267
26
Genetic, parental and lifestyle factors influence telomere length.
Commun Biol 5: 2022 565
15
Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data.
Genome Biol 24: 2023 80
5