ChIP-Seq of TFEB in LT-HSC

Study ID Alternative Stable ID Type
EGAS00001005462 Other

Study Description

ChIP-Seq of TFEB in LT-HSC

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
We show that lysosomes are antagonistically controlled by TFEB and MYC to balance catabolic and anabolic processes required for activating LT-HSC and guiding their lineage fate. TFEB-mediated induction of the endolysosomal pathway for membrane receptor degradation limits LT-HSC metabolic and mitogenic activation; this promotes quiescence and self-renewal and governs erythroid-myeloid commitment. By contrast, MYC engages biosynthetic processes while repressing lysosomal catabolism to drive ... (Show More)
Illumina HiSeq 2500 89

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