Dichotomous regulation of lysosomes by MYC and TFEB controls hematopoietic stem cell fate

Dataset ID Technology Samples
EGAD00001006884 Illumina HiSeq 2500 89

Dataset Description

We show that lysosomes are antagonistically controlled by TFEB and MYC to balance catabolic and anabolic processes required for activating LT-HSC and guiding their lineage fate. TFEB-mediated induction of the endolysosomal pathway for membrane receptor degradation limits LT-HSC metabolic and mitogenic activation; this promotes quiescence and self-renewal and governs erythroid-myeloid commitment. By contrast, MYC engages biosynthetic processes while repressing lysosomal catabolism to drive LT-HSC activation. Collectively, our study identifies lysosomes as a central regulatory hub for proper and coordinated stem cell fate determination.

Who controls access to this dataset

For each dataset that requires controlled access, there is a corresponding Data Access Committee (DAC) who determine access permissions. Access to actual data files is not managed by the EGA. If you need to request access to this data set, please contact:

UHN Genomics Data Access Committee
Contact person: UHN DAC
Email: dac [at] uhn [dot] ca
More details: EGAC00001000912


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