scRNAseq of human primary nasal epithelium differentiated at air-liquid interface exposed to SARS-CoV2
The nasal epithelium is a plausible entry point for SARS-CoV-2, a site of pathogenesis and transmission, and may initiate the host response to SARS-CoV-2. Antiviral interferon responses are critical to outcome of SARS-CoV-2. Yet little is known about the interaction between SARS-CoV-2 and innate immunity in this tissue. Here we applied single-cell RNA sequencing and proteomics to a primary cell model of human primary nasal epithelium differentiated at air-liquid interface.
- Type: Other
- Archiver: EGA European Genome-Phenome Archive
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Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2.
Nat Commun 12: 2021 7092