Deep whole genome ctDNA chronology of treatment-resistant prostate cancer

Study ID Alternative Stable ID Type
EGAS00001005783 Cancer Genomics

Study Description

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
Circulating tumor DNA (ctDNA) in blood plasma is an emerging tool for clinical cancer genotyping and longitudinal disease monitoring. We performed deep whole-genome sequencing of serial plasma and synchronous metastases in patients with aggressive prostate cancer. We comprehensively assess all classes of genomic alterations and demonstrate that ctDNA harbors multiple dominant populations whose evolutionary histories frequently indicate whole-genome doubling and shifts in mutational processes. ... (Show More)
unspecified 117

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