About file location

As the EGA is co-managed by the EMBL-EBI and CRG, files could be located in the UK and/or Spain, as indicated by their respective flags.

Alternatively, files could be located in one of the international Federated EGA nodes, as indicated next to the node's flag.
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Deep whole genome ctDNA chronology of treatment-resistant prostate cancer

Circulating tumor DNA (ctDNA) in blood plasma is an emerging tool for clinical cancer genotyping and longitudinal disease monitoring. We performed deep whole-genome sequencing of serial plasma and synchronous metastases in patients with aggressive prostate cancer. We comprehensively assess all classes of genomic alterations and demonstrate that ctDNA harbors multiple dominant populations whose evolutionary histories frequently indicate whole-genome doubling and shifts in mutational processes. Although tissue and ctDNA showed concordant clonally-expanded cancer driver alterations, each individual metastasis contributed only a minor share of total ctDNA. By comparing serial ctDNA before and after clinical progression on potent androgen receptor (AR) pathway inhibitors, we reveal population restructuring converging solely on AR augmentation as the dominant genomic driver of acquired treatment-resistance. Finally we leverage nucleosome footprints in ctDNA to infer mRNA abundance in synchronously biopsied metastases, including treatment-induced changes in AR pathway transcriptional activity.

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Data Access Policy for the DNA sequencing data generated in the study "Somatic chronology of treatment-resistant prostate cancer via deep whole-genome ctDNA sequencing"

The following data access agreement (DAA) must be filled out by the requester, to be granted access to the data: https://docs.google.com/forms/d/e/1FAIpQLScy4KzxU8JA_3gU3hmHgZYE7mVgvBKYmpZkwBB0vASA9zqAQQ/viewform?usp=sf_link

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001005783 Cancer Genomics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Quality Report
Located in
i
EGAF00005761909 fq.gz 227.4 GB Report
EGAF00005761910 fq.gz 240.1 GB Report
EGAF00005761911 fq.gz 242.0 GB Report
EGAF00005761912 fq.gz 269.6 GB Report
EGAF00005761913 fq.gz 29.7 GB Report
EGAF00005761914 fq.gz 31.0 GB Report
EGAF00005761915 fq.gz 222.2 GB Report
EGAF00005761916 fq.gz 245.0 GB Report
EGAF00005761917 fq.gz 212.6 GB Report
EGAF00005761918 fq.gz 231.4 GB Report
EGAF00005761919 fq.gz 213.9 GB Report
EGAF00005761920 fq.gz 234.6 GB Report
EGAF00005761921 fq.gz 183.3 GB Report
EGAF00005761922 fq.gz 203.1 GB Report
EGAF00005761923 fq.gz 192.9 GB Report
EGAF00005761924 fq.gz 211.1 GB Report
EGAF00005761925 fq.gz 33.0 GB Report
EGAF00005761926 fq.gz 34.9 GB Report
EGAF00005761927 fq.gz 169.5 GB Report
EGAF00005761928 fq.gz 186.3 GB
EGAF00005761929 fq.gz 34.7 GB Report
EGAF00005761930 fq.gz 37.7 GB Report
EGAF00005761931 fq.gz 228.7 GB Report
EGAF00005761932 fq.gz 232.3 GB Report
EGAF00005761933 fq.gz 32.7 GB Report
EGAF00005761934 fq.gz 34.5 GB Report
EGAF00005761935 fq.gz 204.8 GB Report
EGAF00005761936 fq.gz 205.1 GB Report
EGAF00005761937 fq.gz 212.7 GB Report
EGAF00005761938 fq.gz 220.4 GB Report
EGAF00005761939 fq.gz 34.8 GB Report
EGAF00005761940 fq.gz 36.7 GB Report
EGAF00005761941 fq.gz 161.6 GB Report
EGAF00005761942 fq.gz 159.5 GB Report
EGAF00005761943 fq.gz 34.8 GB Report
EGAF00005761944 fq.gz 34.0 GB Report
EGAF00006127311 fq.gz 45.3 GB Report
EGAF00006127312 fq.gz 46.2 GB Report
EGAF00006127313 fq.gz 206.0 GB Report
EGAF00006127314 fq.gz 221.3 GB Report
EGAF00006127315 fq.gz 213.9 GB Report
EGAF00006127316 fq.gz 232.7 GB Report
EGAF00006127317 fq.gz 56.8 GB Report
EGAF00006127318 fq.gz 59.1 GB Report
EGAF00006127319 fq.gz 198.3 GB Report
EGAF00006127320 fq.gz 207.2 GB Report
EGAF00006127321 fq.gz 203.2 GB Report
EGAF00006127322 fq.gz 229.5 GB Report
EGAF00006127323 fq.gz 31.6 GB Report
EGAF00006127324 fq.gz 31.9 GB Report
EGAF00006127325 fq.gz 214.6 GB Report
EGAF00006127326 fq.gz 228.0 GB Report
EGAF00006127327 fq.gz 57.7 GB Report
EGAF00006127328 fq.gz 60.2 GB Report
EGAF00006127329 fq.gz 203.8 GB Report
EGAF00006127330 fq.gz 215.3 GB Report
EGAF00006127331 fq.gz 200.6 GB Report
EGAF00006127332 fq.gz 213.1 GB Report
EGAF00006127333 fq.gz 211.1 GB Report
EGAF00006127334 fq.gz 214.5 GB Report
EGAF00006127335 fq.gz 246.3 GB Report
EGAF00006127336 fq.gz 268.7 GB Report
EGAF00006127337 fq.gz 208.0 GB Report
EGAF00006127338 fq.gz 226.1 GB Report
EGAF00006127339 fq.gz 239.1 GB Report
EGAF00006127340 fq.gz 267.9 GB Report
EGAF00006127341 fq.gz 201.7 GB Report
EGAF00006127342 fq.gz 223.3 GB Report
EGAF00006127343 fq.gz 32.2 GB Report
EGAF00006127344 fq.gz 33.1 GB Report
EGAF00006127345 fq.gz 33.9 GB Report
EGAF00006127346 fq.gz 36.2 GB Report
EGAF00006127347 fq.gz 34.8 GB Report
EGAF00006127348 fq.gz 37.2 GB Report
EGAF00006127349 fq.gz 204.3 GB Report
EGAF00006127350 fq.gz 217.3 GB Report
EGAF00006127351 fq.gz 40.4 GB Report
EGAF00006127352 fq.gz 40.1 GB Report
EGAF00006127353 fq.gz 65.4 GB Report
EGAF00006127354 fq.gz 64.8 GB Report
EGAF00006127355 fq.gz 61.4 GB Report
EGAF00006127356 fq.gz 65.4 GB Report
EGAF00006127357 fq.gz 203.2 GB Report
EGAF00006127358 fq.gz 212.8 GB Report
EGAF00006127359 fq.gz 47.5 GB Report
EGAF00006127360 fq.gz 48.2 GB Report
EGAF00006127361 fq.gz 193.9 GB Report
EGAF00006127362 fq.gz 197.5 GB Report
EGAF00006127363 fq.gz 233.2 GB Report
EGAF00006127364 fq.gz 254.4 GB Report
EGAF00006127365 fq.gz 245.8 GB Report
EGAF00006127366 fq.gz 271.8 GB Report
EGAF00006127367 fq.gz 189.4 GB Report
EGAF00006127368 fq.gz 190.6 GB Report
EGAF00006127369 fq.gz 49.6 GB Report
EGAF00006127370 fq.gz 54.5 GB Report
EGAF00006127371 fq.gz 34.6 GB Report
EGAF00006127372 fq.gz 35.7 GB Report
EGAF00006127373 fq.gz 209.9 GB Report
EGAF00006127374 fq.gz 226.9 GB Report
EGAF00006144270 fq.gz 189.1 GB Report
EGAF00006144271 fq.gz 203.6 GB Report
EGAF00006144272 fq.gz 199.2 GB Report
EGAF00006144273 fq.gz 213.2 GB Report
EGAF00006144274 fq.gz 189.0 GB Report
EGAF00006144275 fq.gz 196.5 GB Report
EGAF00006144276 fq.gz 185.7 GB Report
EGAF00006144277 fq.gz 203.6 GB Report
EGAF00006144278 fq.gz 208.2 GB Report
EGAF00006144279 fq.gz 221.9 GB Report
EGAF00006144280 fq.gz 34.8 GB Report
EGAF00006144281 fq.gz 37.1 GB Report
EGAF00006144282 fq.gz 204.0 GB Report
EGAF00006144283 fq.gz 226.5 GB Report
EGAF00006144284 fq.gz 207.0 GB Report
EGAF00006144285 fq.gz 221.4 GB Report
EGAF00006144286 fq.gz 222.0 GB Report
EGAF00006144287 fq.gz 238.3 GB Report
EGAF00006144288 fq.gz 33.5 GB Report
EGAF00006144289 fq.gz 35.2 GB Report
EGAF00006144290 fq.gz 216.0 GB Report
EGAF00006144291 fq.gz 233.6 GB Report
EGAF00006144292 fq.gz 31.3 GB Report
EGAF00006144293 fq.gz 35.3 GB Report
EGAF00006144294 fq.gz 198.9 GB Report
EGAF00006144295 fq.gz 216.2 GB Report
EGAF00006144296 fq.gz 64.3 GB Report
EGAF00006144297 fq.gz 72.0 GB Report
EGAF00006144298 fq.gz 152.0 GB Report
EGAF00006144299 fq.gz 168.1 GB Report
EGAF00006144300 fq.gz 169.6 GB Report
EGAF00006144301 fq.gz 191.8 GB Report
EGAF00006144302 fq.gz 203.8 GB Report
EGAF00006144303 fq.gz 220.2 GB Report
EGAF00006144304 fq.gz 34.2 GB Report
EGAF00006144305 fq.gz 36.1 GB Report
EGAF00006144306 fq.gz 61.6 GB Report
EGAF00006144307 fq.gz 71.5 GB Report
EGAF00006144308 fq.gz 223.7 GB Report
EGAF00006144309 fq.gz 244.1 GB Report
EGAF00006144310 fq.gz 32.6 GB Report
EGAF00006144311 fq.gz 32.3 GB Report
EGAF00006144312 fq.gz 210.0 GB Report
EGAF00006144313 fq.gz 224.6 GB Report
EGAF00006144314 fq.gz 32.5 GB Report
EGAF00006144315 fq.gz 34.5 GB Report
EGAF00006144316 fq.gz 162.8 GB Report
EGAF00006144317 fq.gz 179.2 GB Report
EGAF00006144318 fq.gz 155.1 GB Report
EGAF00006144319 fq.gz 169.5 GB Report
EGAF00006144320 fq.gz 31.5 GB Report
EGAF00006144321 fq.gz 35.2 GB Report
EGAF00006144322 fq.gz 178.6 GB Report
EGAF00006144323 fq.gz 187.2 GB Report
EGAF00006144324 fq.gz 34.1 GB Report
EGAF00006144325 fq.gz 36.0 GB Report
EGAF00006144326 fq.gz 33.4 GB Report
EGAF00006144327 fq.gz 36.1 GB Report
EGAF00006144328 fq.gz 34.7 GB Report
EGAF00006144329 fq.gz 34.5 GB Report
EGAF00006144330 fq.gz 170.4 GB Report
EGAF00006144331 fq.gz 186.8 GB Report
EGAF00006144332 fq.gz 31.5 GB Report
EGAF00006144333 fq.gz 34.5 GB Report
EGAF00006144334 fq.gz 33.7 GB Report
EGAF00006144335 fq.gz 36.6 GB Report
EGAF00006144336 fq.gz 33.0 GB Report
EGAF00006144337 fq.gz 35.2 GB Report
EGAF00006144342 fq.gz 63.9 GB Report
EGAF00006144343 fq.gz 69.5 GB Report
EGAF00006201206 fq.gz 117.5 GB Report
EGAF00006201207 fq.gz 134.8 GB Report
EGAF00006201208 fq.gz 65.6 GB Report
EGAF00006201209 fq.gz 87.1 GB Report
EGAF00006201210 fq.gz 70.3 GB Report
EGAF00006201211 fq.gz 99.3 GB Report
EGAF00006201212 fq.gz 66.7 GB Report
EGAF00006201213 fq.gz 93.3 GB Report
EGAF00006201214 fq.gz 62.6 GB Report
EGAF00006201215 fq.gz 80.6 GB Report
EGAF00006201216 fq.gz 74.4 GB Report
EGAF00006201217 fq.gz 98.8 GB Report
EGAF00006201218 fq.gz 200.4 GB Report
EGAF00006201219 fq.gz 212.3 GB Report
EGAF00006201220 fq.gz 61.6 GB Report
EGAF00006201221 fq.gz 85.3 GB Report
EGAF00006201222 fq.gz 207.3 GB Report
EGAF00006201223 fq.gz 207.2 GB Report
EGAF00006201224 fq.gz 67.5 GB Report
EGAF00006201225 fq.gz 94.3 GB Report
EGAF00006201226 fq.gz 220.9 GB Report
EGAF00006201227 fq.gz 230.2 GB Report
EGAF00006201228 fq.gz 68.2 GB Report
EGAF00006201229 fq.gz 89.2 GB Report
EGAF00006201230 fq.gz 176.9 GB Report
EGAF00006201231 fq.gz 172.0 GB Report
EGAF00006201232 fq.gz 67.8 GB Report
EGAF00006201233 fq.gz 93.7 GB Report
EGAF00006201234 fq.gz 171.4 GB Report
EGAF00006201235 fq.gz 189.1 GB Report
EGAF00006201236 fq.gz 65.7 GB Report
EGAF00006201237 fq.gz 86.5 GB Report
EGAF00006201238 fq.gz 229.6 GB Report
EGAF00006201239 fq.gz 238.0 GB Report
EGAF00006201240 fq.gz 70.2 GB Report
EGAF00006201241 fq.gz 94.6 GB Report
EGAF00006201242 fq.gz 68.6 GB Report
EGAF00006201243 fq.gz 95.6 GB Report
EGAF00006201244 fq.gz 66.5 GB Report
EGAF00006201245 fq.gz 87.3 GB Report
EGAF00006201246 fq.gz 66.1 GB Report
EGAF00006201247 fq.gz 87.4 GB Report
EGAF00006204849 fq.gz 31.4 GB Report
EGAF00006204850 fq.gz 32.5 GB Report
EGAF00006204851 fq.gz 30.6 GB Report
EGAF00006204852 fq.gz 32.1 GB Report
EGAF00006204853 fq.gz 33.3 GB Report
EGAF00006204854 fq.gz 37.8 GB Report
EGAF00006204855 fq.gz 165.4 GB
EGAF00006204856 fq.gz 171.4 GB
EGAF00006204857 fq.gz 162.5 GB Report
EGAF00006204858 fq.gz 180.0 GB Report
EGAF00006204859 fq.gz 28.7 GB Report
EGAF00006204860 fq.gz 33.8 GB Report
EGAF00006204861 fq.gz 196.7 GB
EGAF00006204862 fq.gz 217.9 GB
EGAF00006204863 fq.gz 30.9 GB Report
EGAF00006204864 fq.gz 35.3 GB Report
EGAF00006204865 fq.gz 217.5 GB
EGAF00006204866 fq.gz 235.8 GB
EGAF00006204867 fq.gz 33.3 GB Report
EGAF00006204868 fq.gz 38.3 GB Report
EGAF00006204869 fq.gz 212.4 GB Report
EGAF00006204870 fq.gz 237.2 GB Report
234 Files (31.3 TB)