Brain_Disease_Wellcome_Leap_Delta_Tissue_Spatial

Utilising Spatial Transcriptomics to investigate how the tumour microenvironment regulates glioblastoma cell states.

1 Dataset

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Dataset ID	Description	Technology	Samples
EGAD00001015527	Cancer cells display heterogeneous and dynamic states in glioblastoma, but how these malignant states arise and whether they follow a tractable cellular trajectory across tumours is poorly understood. Here, we generate a deep single cell and spatial multi-region atlas of 12 isocitrate dehydrogenase wild-type (IDH-wt) primary glioblastomas that integrates transcriptomic, epigenomic and genomic analysis to comprehensively characterise their tumour heterogeneity. The datasets in this study include sequencing data from Visium spatial transcriptomic (10x Genomics) profiling of these tumours.	Illumina NovaSeq 6000	1