CUT&RUN of AML1-ETO binding occupancy following miR-130a KD in Kasumi-1 cells
|Study ID||Alternative Stable ID||Type|
Study Datasets 1 dataset.
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In this study, we identified miR-130a as a regulator of HSC self-renewal and differentiation. To characterize gene expression changes following enforced expression of miR-130a OE, we performed RNA-seq in CD34+ cord blood (CB) cells transduced with control and miR-130a OE lentiviruses. To capture miRNA targets in an unbiased, transcriptome-wide manner, we perfomed enhanced CLIPseq procol in 2 replicates of CD34+ CB cells and Kasumi-1 cell line, which represent a model system for t(8;21) AML. We ... (Show More)
|Illumina HiSeq 2500,NextSeq 500||36|