RNAseq Iron-Treated iPSC-derived Microglia
Iron accumulation in microglia has been observed in Alzheimer’s disease and other neurodegenerative disorders and is thought to contribute to disease progression through various mechanisms including neuroinflammation. To study the interaction between iron accumulation and inflammation, we treated human induced pluripotent stem cell-derived microglia (iPSC-MG) with an increasing concentration of iron, in combination with inflammatory stimuli such as interferon gamma and amyloid β, and performed RNA sequencing.
- Type: Other
- Archiver: EGA European Genome-Phenome Archive
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|EGAD00001008660||Illumina NovaSeq 6000||24|
Iron accumulation induces oxidative stress, while depressing inflammatory polarization in human iPSC-derived microglia.
Stem Cell Reports 17: 2022 1351-1365