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RNAseq Iron-Treated iPSC-derived Microglia

Iron accumulation in microglia has been observed in Alzheimer’s disease and other neurodegenerative disorders and is thought to contribute to disease progression through various mechanisms including neuroinflammation. To study the interaction between iron accumulation and inflammation, we treated human induced pluripotent stem cell-derived microglia (iPSC-MG) with an increasing concentration of iron, in combination with inflammatory stimuli such as interferon gamma and amyloid β, and performed RNA sequencing.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001008660 Illumina NovaSeq 6000 24
Publications Citations
Iron accumulation induces oxidative stress, while depressing inflammatory polarization in human iPSC-derived microglia.
Stem Cell Reports 17: 2022 1351-1365