Tumorigenic role of Musashi-2 in aggressive mantle cell lymphoma
SOX11 is overexpressed in the highly aggressive conventional mantle cell lymphoma (MCL) but rarely in the indolent non-nodal MCL subtype. We performed RNA-seq of SOX11+ and SOX11- MCLs to search for SOX11-regulated genes that contributed to MCL clinical evolution, identifying Musashi-2 (MSI2) stem cell-related gene. By performing RNA-seq upon MSI2 knockdown or inhibition in MCL, we identified MSI2 as a potential target to inhibit drug resistance in aggressive MCLs.
- Type: Other
- Archiver: EGA European Genome-Phenome Archive
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
|EGAD00001009420||Illumina HiSeq 2500||14|
|EGAD00001009421||Illumina HiSeq 2500||12|
|EGAD00001009422||Illumina HiSeq 2500||12|
Tumorigenic role of Musashi-2 in aggressive mantle cell lymphoma.
Leukemia 37: 2023 408-421