Spatially resolved transcriptomics reveals profound subclonal heterogeneity and T cell dysfunction in extramedullary myeloma

Investigating the spatial architecture and microenvironment of EMD lesions in Multiple Myeloma patients using spatial whole transcriptome sequencing (10X Visium), tomography for spatially resolved transcriptomics (TOMO-seq), and single-cell RNA sequencing (scRNAseq)

Type: RNASeq
Archiver: European Genome-Phenome Archive (EGA)

3 Datasets

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000000334	This data set contains the raw FASTq files and processed files of scRNA seq experiment which were conducted on 3 EMD samples. The libraries were generated using 10x genomics Dual index Single Cell 3' v3.1. The processed files are TSV files of features, barcodes, and gene expression matrix	NextSeq 2000	3
EGAD50000000335	This object contains raw FATSq files and processed files of the 43 sections of an entire EMD lesion of one patient PT01A. The raw files represents bulk RNA sequencing of each of the sections.The processed file is a CSV file that contains gene expression.	NextSeq 2000	1
EGAD50000000336	This data set contains raw FASTQ files and processed files of spatial transcriptomics of 6 EMD samples collected from MM patients. The processed files contains the h5 expression matrices, Image of the Visium slide, and TSV of spatial coordinates. Patients whom are included in this data set are PT01A, PT01B, PT02, PT03, PT07, and PT08.	NextSeq 2000	8