single cell data from HPV-positive head and neck cancer patients receiving induction CTLA-4 and PD-1 immune checkpoint blockade

Baseline and on-treatment tumor samples from human papillomavirus-positive oropharynx cancer patients receiving anti-CTLA-4 and anti-PD-1 immune checkpoint blockade were analyzed by single-cell RNA and TCR sequencing.

Type: Transcriptome Sequencing
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000000487	Baseline and on-treatment tumor samples from human papillomavirus-positive oropharynx cancer patients receiving anti-CTLA-4 and anti-PD-1 immune checkpoint blockade were analyzed by single-cell RNA and TCR sequencing.	Illumina NovaSeq 6000	65

Publications	Citations
Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade. Jiang X, Rudqvist NP, Jiang B, Ye S, He S, Liang Q, Dou J, Williams MD, Dunn JD, Johnson JM, Akagi K, Xiao W, Liang S, Elayavalli S, Sun B, Parra ER, Ferrarotto R, Garden AS, Fuller CD, Reddy J, Gross ND, Lango MN, Leung CH, Liu S, Liu DD, Li M, Lee JJ, Curran MA, Phan J, Chen K, Gillison ML. Cancer Discov 15: 2025 1569-1592	2

Publications

Citations

Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade.
Jiang X, Rudqvist NP, Jiang B, Ye S, He S, Liang Q, Dou J, Williams MD, Dunn JD, Johnson JM, Akagi K, Xiao W, Liang S, Elayavalli S, Sun B, Parra ER, Ferrarotto R, Garden AS, Fuller CD, Reddy J, Gross ND, Lango MN, Leung CH, Liu S, Liu DD, Li M, Lee JJ, Curran MA, Phan J, Chen K, Gillison ML. Cancer Discov 15: 2025 1569-1592