Comprehensive molecular portrait reveals genetic diversity and distinct molecular subtypes of small intestinal neuroendocrine tumors

This study aims to characterize neuroendocrine tumors of the small intestine (siNETs) from genomic, transcriptomic, epigenomic, and clinical perspectives. Involving 122 patients and 219 samples, we generated whole-genome sequencing data, RNA sequencing data, genotyping arrays, and methylation arrays to conduct an integrative analysis of this rare tumor type. Our findings identify distinct molecular subtypes that correlate with siNET clinical features.

Type: Cancer Genomics
Archiver: European Genome-Phenome Archive (EGA)

3 Datasets 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000000905	Genotyping arrays for 183 samples from patients with a neuroendocrine tumor of the small intestine. All samples have been hybridized on Illumina GSA-MD v3 arrays with standard automated protocols. Reading of the chips was performed on Illumina iScan+ scanners and this file is the result of primary analysis done using Illumina GenomeStudio software. It contains data for 147 tumors, 2 adenomas, 1 lymph node, 19 mesenteric nodules, 6 liver metastasis and 8 normal ileum samples.	unspecified	183
EGAD50000000906	This dataset contains 206 RNASeq samples from a cohort of patients with neuroendocrine tumors of the small intestine. Libraries were prepared using a Illumina TruSeq Stranded mRNA kit following the manufacturer’s recommendations. Sequencing was performed on Illumina Novaseq6000 machine with a 2x75bp paired-end fashion. This dataset contains data for 169 tumors, 22 mesenteric nodules, 8 liver metastases, 2 adenomas, 1 lymph node and 4 normal ileum samples.	Illumina NovaSeq 6000	206
EGAD50000000907	This dataset contains whole genome sequences for 13 patients with neuroendocrine (unique/multiple) tumor(s) of the small intestine. There are in total 25 tumor and 12 matched normal genomes. Libraries were prepared using a Illumina DNA PCR Free kit following the manufacturer’s recommendations and sequencing was performed on Illumina Novaseq6000 machine with a 2x151bp paired-end fashion. It contains data for : - 1 patient with 4 tumors and 1 matched normal - 1 patient with 3 tumors and 1 matched normal - 1 patient with 2 tumors, 1 liver metastasis and 1 matched normal - 2 patients with 1 tumor, 1 mesenteric nodule and 1 matched normal - 7 patients with 1 tumor and 1 matched normal - 1 patient with 3 tumors and 1 mesenteric nodule	Illumina NovaSeq 6000	37

Publications	Citations
Comprehensive molecular portrait reveals genetic diversity and distinct molecular subtypes of small intestinal neuroendocrine tumors. Patte C, Pommier RM, Ferrari A, Fei-Lei Chung F, Ouzounova M, Moullé P, Richaud M, Khoueiry R, Hervieu M, Breusa S, Allio M, Rama N, Gérard L, Hervieu V, Poncet G, Fenouil T, Cahais V, Sertier AS, Boland A, Bacq-Daian D, Ducarouge B, Marie JC, Deleuze JF, Viari A, Scoazec JY, Roche C, Mehlen P, Walter T, Gibert B. Nat Commun 16: 2025 2197	0

Publications

Citations

Comprehensive molecular portrait reveals genetic diversity and distinct molecular subtypes of small intestinal neuroendocrine tumors.
Patte C, Pommier RM, Ferrari A, Fei-Lei Chung F, Ouzounova M, Moullé P, Richaud M, Khoueiry R, Hervieu M, Breusa S, Allio M, Rama N, Gérard L, Hervieu V, Poncet G, Fenouil T, Cahais V, Sertier AS, Boland A, Bacq-Daian D, Ducarouge B, Marie JC, Deleuze JF, Viari A, Scoazec JY, Roche C, Mehlen P, Walter T, Gibert B. Nat Commun 16: 2025 2197