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Integrated Multiomics Uncovers Distinct Macrophage Alterations in Human Metabolic dysfunction-Associated Steatohepatitis Progression

We report single-nuclei RNA sequencing data from human livers in metabolic dysfunction-associated steatotic liver disease (MASLD) patients.

Type: Transcriptome Sequencing
Archive: European Genome-phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000001129	We report single-nuclei RNA sequencing data (n=18) from human livers in metabolic dysfunction-associated steatotic liver disease (MASLD) patients. there are 5 MASH, 4 MASL, 5 control obese and 4 control lean samples.	Illumina NovaSeq 6000	18

Publications	Citations
Integrated multi-omics identifies distinct macrophage alterations during progression of metabolic dysfunction-associated steatohepatitis. Boesch M, Anak S, El Abyad D, Ostyn T, Antoranz A, My Van T, Newhouse D, Myers C, Van Melkebeke L, Palmer J, Saffarzadeh N, Chui JS, Feio-Azevedo R, Smets L, Shankar G, Dubroja Lakić N, Calvo PL, Voet T, Clark J, Cockell S, Lannoo M, Deleus E, Jaekers J, Topal H, Topal B, Schneider KM, Vacca M, Allison M, Ekstedt M, Boursier J, Bugianesi E, Ratziu V, De Smet F, Boeckx B, Daly AK, Schattenberg JM, Verbeek J, Bosisio F, Lambrechts D, Roskams T, Schneider CV, Francque S, Korf H, Härtlova A, Tiniakos D, Anstee QM, van der Merwe S, Govaere O. Nat Genet 58: 2026 1295-1307	0

Publications

Citations

Integrated multi-omics identifies distinct macrophage alterations during progression of metabolic dysfunction-associated steatohepatitis.
Boesch M, Anak S, El Abyad D, Ostyn T, Antoranz A, My Van T, Newhouse D, Myers C, Van Melkebeke L, Palmer J, Saffarzadeh N, Chui JS, Feio-Azevedo R, Smets L, Shankar G, Dubroja Lakić N, Calvo PL, Voet T, Clark J, Cockell S, Lannoo M, Deleus E, Jaekers J, Topal H, Topal B, Schneider KM, Vacca M, Allison M, Ekstedt M, Boursier J, Bugianesi E, Ratziu V, De Smet F, Boeckx B, Daly AK, Schattenberg JM, Verbeek J, Bosisio F, Lambrechts D, Roskams T, Schneider CV, Francque S, Korf H, Härtlova A, Tiniakos D, Anstee QM, van der Merwe S, Govaere O. Nat Genet 58: 2026 1295-1307