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Transcriptomic profiling of myeloid cells from secondary lymphoid organs (lymph nodes and tonsils) from lymphoma patients and controls.

Despite their recognized impact on the pathogenesis and prognosis of B-cell lymphoma, tumor-associated macrophages (TAM) have not been extensively explored in diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL). We investigated mononuclear phagocyte (MNP) heterogeneity using single cell RNA sequencing (scRNAseq) in B-cell lymphoma lymph nodes compared to reactive secondary lymphoid organs (lymph nodes and tonsils).

Type: Transcriptome Analysis
Archiver: European Genome-phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000001629	This dataset contains fastq files from scRNAseq dataset of myeloid cells from secondary lymphoid organs (lymph nodes and tonsil) from lymphoma patients (3 FL and 3 DLBCL) and controls (3 reactive tonsils and 3 reactive lymph nodes). For HTO libraries, demultiplexing barcodes are available in samples descriptions.	Illumina NovaSeq 6000	8

Publications	Citations
Myeloid landscape profiling identifies DLBCL-specific suppressive macrophages colocalized with blood endothelial cells. Ferrant J, Le Gallou S, Padonou F, Dubec-Fleury C, Leonard S, Papa I, Brottier C, Pangault C, Barthel A, Launay V, Manson G, Hoareau B, Deleurme L, Monvoisin C, Albaud B, Shipp MA, Van Acker N, Laurent C, Llamas Gutierrez F, Michaud HA, Bonnefoy N, Pécot T, Tarte K, Roussel M. Blood Adv 10: 2026 1217-1232	0

Publications

Citations

Myeloid landscape profiling identifies DLBCL-specific suppressive macrophages colocalized with blood endothelial cells.
Ferrant J, Le Gallou S, Padonou F, Dubec-Fleury C, Leonard S, Papa I, Brottier C, Pangault C, Barthel A, Launay V, Manson G, Hoareau B, Deleurme L, Monvoisin C, Albaud B, Shipp MA, Van Acker N, Laurent C, Llamas Gutierrez F, Michaud HA, Bonnefoy N, Pécot T, Tarte K, Roussel M. Blood Adv 10: 2026 1217-1232