Copied to clipboard!

Genomic evolution of pancreatic cancer at single-cell resolution

This project assesses genomic evolution of pancreatic cancer using the Mission Bio Tapestri platform and Whole Exome Sequencing. The Mission Bio Tapestri platform is a single-cell DNA sequencing platform using a targeted gene panel to assess SNV/CNV. Several samples, including primary and metastatic tissue, were used to investigate changes at single-cell resolution.

Type: Cancer Genomics
Archiver: European Genome-phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000001936	This dataset comprises single-cell DNA sequencing data for selected pancreatic ductal adenocarcinoma (PDAC) autopsy samples. It employs a targeted gene panel to identify single nucleotide variants (SNVs) and copy number variations (CNVs) using the Mission Bio Tapestri platform. The samples encompass primary and metastatic tissue from selected PDAC patients. This dataset includes 74 sample-level BAM files and 24 patient-level H5 files, generated by the MissionBio pipeline.	Illumina NovaSeq 6000	98

Publications	Citations
Genomic evolution of pancreatic cancer at single-cell resolution. Zhang H, Sashittal P, Karnoub ER, Jakatdar A, Umeda S, Hong J, Noronha AM, Cardenas A, Erakky A, McIntyre CA, Hayashi A, Lecomte N, Hilmi M, Park W, Pang N, O'Reilly EM, Wei AC, Raphael BJ, Iacobuzio-Donahue CA. Nat Genet 58: 2026 355-365	0