Copied to clipboard!

RNASeq from ASTEROID biopsy samples

ASTEROID Phase 1 trial of combination IAP inhibitor ASTX660 and pembrolizumab. Tumour biopsies taken before and after 7-day run-in of ASTX660 were sequenced.

Type: RNASeq
Archive: European Genome-phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000002935	RNAseq data from paired tumour biopsies from ASTEROID subjects (n=30), Fastq files	Illumina NovaSeq X	30

Publications	Citations
IAP antagonist tolinapant (ASTX660) in combination with pembrolizumab in advanced solid tumors: a phase I trial. Tiu C, Yau W, Tenev T, Lionarons D, Leung C, Sanchez-Perez V, Codacci-Pisanelli G, Lai X, Zachariou A, Hussain A, Prout T, Parmar M, Baikady B, Goicoechea M, Layzell S, Guppy N, Roxanis I, Lund T, Dos Reis DC, Almeida CP, Silveira TL, Ferreira A, Gurel B, Bertan C, Crespo M, Flohr P, Baker AM, Graham T, Zapata L, Salas C, Mandal S, Dunlop A, Sims M, Ward G, Smyth T, Jueliger S, Davis M, Potapov I, Oganesian A, Chan D, Leino M, Basu S, Samson A, Murphy JM, Tunariu N, Johnston EW, Ring A, Turner N, Tutt ANJ, Swain A, Minchom A, Sharp A, Paschalis A, Banerji U, de Bono J, Basu B, Yap C, Haider S, Lopez J, Meier P. Nat Commun 17: 2026 11255	0

Publications

Citations

IAP antagonist tolinapant (ASTX660) in combination with pembrolizumab in advanced solid tumors: a phase I trial.
Tiu C, Yau W, Tenev T, Lionarons D, Leung C, Sanchez-Perez V, Codacci-Pisanelli G, Lai X, Zachariou A, Hussain A, Prout T, Parmar M, Baikady B, Goicoechea M, Layzell S, Guppy N, Roxanis I, Lund T, Dos Reis DC, Almeida CP, Silveira TL, Ferreira A, Gurel B, Bertan C, Crespo M, Flohr P, Baker AM, Graham T, Zapata L, Salas C, Mandal S, Dunlop A, Sims M, Ward G, Smyth T, Jueliger S, Davis M, Potapov I, Oganesian A, Chan D, Leino M, Basu S, Samson A, Murphy JM, Tunariu N, Johnston EW, Ring A, Turner N, Tutt ANJ, Swain A, Minchom A, Sharp A, Paschalis A, Banerji U, de Bono J, Basu B, Yap C, Haider S, Lopez J, Meier P. Nat Commun 17: 2026 11255