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Single-Cell Multiomic and Whole-Genome Profiling of Primary and Metastatic Colorectal Cancer

This study contains controlled-access single-cell multiomic sequencing (scRNA-seq and scATAC-seq) data generated from patients with colorectal cancer, including 33 primary tumours, 11 metastatic lesions, and 7 adjacent normal tissue samples. Whole-genome sequencing (WGS) data are available for the tumour samples. These data were generated to investigate the genomic and epigenomic landscape of colorectal cancer and to identify recurrent regulatory alterations associated with tumour progression and metastasis.

Type: Epigenetics
Archive: European Genome-phenome Archive (EGA)

4 Datasets

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000002942	Whole-genome sequencing (WGS) data generated from matched germline blood DNA samples obtained from patients with primary or metastatic colorectal adenocarcinoma (n=37). These data were generated as part of a multiomic study integrating whole-genome sequencing with single-cell multiome profiling to investigate recurrent epigenetic alterations in colorectal cancer evolution and the tumour microenvironment.	Illumina NovaSeq 6000	37
EGAD50000002943	WGS samples of primary (n=33) and metastatic (n=11) colorectal cancer tissues related to Livanova et al. manuscript 'Epigenetic evolution of colorectal cancer and its microenvironment reveals new vulnerabilities'	Illumina NovaSeq 6000	44
EGAD50000002944	This dataset contains single-cell 10x Genomics Multiome ATAC-seq data from 33 primary colorectal cancer, 11 metastatic colorectal cancer, and 7 matched normal colon tissue samples generated as part of the study "Epigenetic evolution of colorectal cancer and its microenvironment reveals novel vulnerabilities."	Illumina NovaSeq 6000	50
EGAD50000002945	This dataset contains single-cell 10x Genomics Multiome RNA-seq data from 33 primary colorectal cancer, 11 metastatic colorectal cancer, and 7 matched normal colon tissue samples generated as part of the study "Epigenetic evolution of colorectal cancer and its microenvironment reveals novel vulnerabilities."	Illumina NovaSeq 6000	50