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IMMUcan Nirvana NSCLC4 cohort

The goal of IMMUcan is to understand how the immune system interacts with tumors and how therapeutic interventions influence this interaction. This cohort includes patients treated with PD-1 Inhibitor and Chemotherapy with Concurrent Irradiation at Varied Tumour Sites in Advanced Non-small Cell Lung Cancer from Nirvana (NCT03774732). Comprehensive profiling data are integrated with longitudinally collected clinical information. Cellular profiling of the same tumor samples was performed using multiplex immunofluorescence imaging, imaging mass cytometry, and H&E staining.

Type: Cancer Genomics
Archive: European Genome-phenome Archive (EGA)

2 Datasets

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000003044	The goal of IMMUcan is to understand how the immune system interacts with tumors and how therapeutic interventions influence this interaction. This cohort includes patients from the Nirvana (NCT03774732) trial treated with PD-1 Inhibitor and Chemotherapy with Concurrent Irradiation at Varied Tumour Sites in Advanced Non-small Cell Lung Cancer. This dataset contains transcriptomics data processed with the STAR pipeline. Two sequencing kits were employed: Roche KAPA for high-quality RNA samples and Takara SMART-Seq Stranded for samples with limited RNA quantities. It contains gene-level counts.	Illumina Genome Analyzer II	53
EGAD50000003045	The goal of IMMUcan is to understand how the immune system interacts with tumors and how therapeutic interventions influence this interaction. This cohort includes patients from the Nirvana (NCT03774732) trial treated with PD-1 Inhibitor and Chemotherapy with Concurrent Irradiation at Varied Tumour Sites in Advanced Non-small Cell Lung Cancer. This dataset contains whole exome sequencing data from tumor samples processed with the Vegan pipeline. Variant calling is performed against two Panel of Normals (one for each biological sex) computed (https://gatk.broadinstitute.org/hc/en-us/articles/360035531132) using 60 samples from the same sex, from the IMMUcan study. It includes SNP and CNV calling.	Illumina Genome Analyzer II	52