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Association of OXTR and AVPR1A Genetic Variation with Empathy and Dark Triad Traits in a Non-Clinical Human Sample

This study investigates associations between variation in OXTR and AVPR1A, empathy, and Dark Triad personality traits in 506 participants from a non-clinical human sample. OXTR rs53576 and rs2254298 were genotyped using TaqMan assays, while AVPR1A RS1 and RS3 microsatellites were characterized by capillary electrophoresis and fragment-length analysis. Empathy was assessed using the Interpersonal Reactivity Index (IRI), and Machiavellianism, narcissism, and psychopathy were assessed using the Short Dark Triad (SD3). The study evaluates direct genotype–phenotype associations and indirect associations involving specific dimensions of empathy.

Type: Population Genomics
Archive: European Genome-phenome Archive (EGA)

1 Dataset

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Dataset ID	Description	Technology	Samples
EGAD50000003115	This controlled-access dataset contains linked genotype and behavioral phenotype data from 506 participants in a non-clinical human sample. Genetic data include OXTR rs53576 and rs2254298 genotypes generated using TaqMan assays and AVPR1A RS1 and RS3 microsatellite allele lengths and derived genotype groupings obtained by capillary electrophoresis. Behavioral data include age, biological sex, sample group, Interpersonal Reactivity Index scores, and Short Dark Triad scores. The dataset comprises two tab-delimited files linked to the same 506 EGA samples.		506