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Genomic correlates with survival after treatment of oesophageal adenocarcinoma by surgery alone

A 451 cancer-associated gene panel, described in McCabe et al. 2019, was used to assess genomic alterations associated with survival in a Swedish cohort of 65 oesophageal adenocarcinoma (OAC) patients who underwent surgical resection without perioperative treatment. Primary tumour tissues and matched normal squamous oesophagus tissues were collected from each individual. Laboratory studies were performed at the Centre for Applied Medical Research (AMR) and sequencing was performed at the Kinghorn Cancer Centre. 64 of 65 cancer samples and 61 matched squamous oesophageal mucosa control tissues were successfully sequenced and passed minimal quality metrics.

Type: Cancer Genomics
Archive: European Genome-phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000003139	Genome sequencing was used to assess genomic alterations associated with survival in a Swedish cohort of 65 oesophageal adenocarcinoma (OAC) patients. Primary tumour tissues and matched normal squamous oesophagus tissues were sequenced using a 451 cancer-associated gene panel. This dataset consists of sequence data in fastq format.	Illumina HiSeq 2500	125

Publications	Citations
Development and validation of a targeted gene sequencing panel for application to disparate cancers. McCabe MJ, Gauthier MA, Chan CL, Thompson TJ, De Sousa SMC, Puttick C, Grady JP, Gayevskiy V, Tao J, Ying K, Cipponi A, Deng N, Swarbrick A, Thomas ML, Lord RV, Johns AL, Kohonen-Corish M, O'Toole SA, Clark J, Mueller SA, Gupta R, McCormack AI, Dinger ME, Cowley MJ, kConFab. Sci Rep 9: 2019 17052	26