Data Access Committee for Institut Curie

Mr Julien Guérin
julien.guerin@curie.fr

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Dataset ID	Description	Technology	Samples
EGAD00001004554	Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. Despite improvement of diagnosis and treatment of the primary tumor, there is no effective treatment of metastatic disease and approximately half of patients will die within one year or less following metastases detection. Tumor heterogeneity has been proposed as a key factor of drug resistance. However, it has been scarcely studied in UM. The present project aims searching for specific drivers of the metastatic progression, describing the genomic and transcriptomic landscape of metastatic UM, exploring tumor heterogeneity and investigating its role in drug resistance. Thus whole exome sequencing and transcriptomics have been performed on constitutional, primary tumor and metastatic samples from 28 UM patients.	Illumina HiSeq 2500	110
EGAD00001007528	RNAseq from 13 uveal melanoma patients	Illumina HiSeq 2500	13
EGAD00010001463	Genotype cases using Illumina HumanOmni5	Illumina HumanOmni5	279