Translational Oncogenomics, ICR

Dac ID Contact Person Email Access Information
EGAC00001001092 Dr Marco Gerlinger marco [dot] gerlinger [at] icr [dot] ac [dot] uk No additional information is available

This DAC controls 2 datasets:

Dataset ID Description Technology Samples
EGAD00001004501 Genomic and transcriptomic data from a cohort of 35 RAS wild-type colorectal cancers. All 35 cases were DNA sequenced at baseline (BL) before treatment with single agent cetuximab. Progressive disease (PD)-biopsies were taken shortly after radiological progression and successfully exome sequenced from 24/35 cases. mRNA sequencing is available for 25 Baseline and 15 PD samples. ctDNA from 9 cases that progressed after prolonged cetuximab benefit were also deep sequenced. HiSeq X Ten,Illumina HiSeq 2000,Illumina HiSeq 2500 155
EGAD00001004594 The dataset includes multi-region exome sequencing (MSeq) of four resected treatment naïve mismatch repair deficient gastro-esophageal cancers. Paired-end sequencing was performed on the Illumina HiSeq 2500 or NovaSeq 6000 with a target depth of 200X. Seven primary tumor regions along with tumor-adjacent non malignant tissue were subjected to MSeq. An additional two lymph node metastases were also included from each of two cases. Illumina HiSeq 2500,Illumina NovaSeq 6000 35