Translational Oncogenomics, ICR

Dr Marco Gerlinger
marco.gerlinger@icr.ac.uk

Request Access

Dataset ID	Description	Technology	Samples
EGAD00001004501	Genomic and transcriptomic data from a cohort of 35 RAS wild-type colorectal cancers. All 35 cases were DNA sequenced at baseline (BL) before treatment with single agent cetuximab. Progressive disease (PD)-biopsies were taken shortly after radiological progression and successfully exome sequenced from 24/35 cases. mRNA sequencing is available for 25 Baseline and 15 PD samples. ctDNA from 9 cases that progressed after prolonged cetuximab benefit were also deep sequenced.	HiSeq X Ten Illumina HiSeq 2000 Illumina HiSeq 2500	155
EGAD00001004594	The dataset includes multi-region exome sequencing (MSeq) of four resected treatment naïve mismatch repair deficient gastro-esophageal cancers. Paired-end sequencing was performed on the Illumina HiSeq 2500 or NovaSeq 6000 with a target depth of 200X. Seven primary tumor regions along with tumor-adjacent non malignant tissue were subjected to MSeq. An additional two lymph node metastases were also included from each of two cases.	Illumina HiSeq 2500 Illumina NovaSeq 6000	35