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Genomic and transcriptomic determinants of therapy resistance and immune landscape evolution during anti-EGFR treatment in colorectal cancer

Genomic and transcriptomic data from a cohort of 35 RAS wild-type colorectal cancers. All 35 cases were DNA sequenced at baseline (BL) before treatment with single agent cetuximab. Progressive disease (PD)-biopsies were taken shortly after radiological progression and successfully exome sequenced from 24/35 cases. mRNA sequencing is available for 25 Baseline and 15 PD samples. ctDNA from 9 cases that progressed after prolonged cetuximab benefit were also deep sequenced.

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Access to data will be granted to qualified researchers for academic/non-commercial research use subject to signing a data transfer agreement which restricts publication and dissemination of the the dataset and which prohibits any attempt to re-identify any of the study patients. If you need to request access to this data set, please contact: Translational Oncogenomics Lab - Data Access Committee marco.gerlinger@icr.ac.uk

Access to data will be granted to qualified researchers for academic/non-commercial research use subject to signing a data transfer agreement which restricts publication and dissemination of the the dataset and which prohibits any attempt to re-identify any of the study patients. If you need to request access to this data set, please contact: Translational Oncogenomics Lab - Data Access Committee marco.gerlinger@icr.ac.uk

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001003367 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00002273524 bam 8.0 GB
EGAF00002273525 bam 8.4 GB
EGAF00002273526 bam 8.1 GB
EGAF00002273527 bam 10.7 GB
EGAF00002273528 bam 7.8 GB
EGAF00002273529 bam 9.3 GB
EGAF00002273530 bam 8.7 GB
EGAF00002273531 bam 10.3 GB
EGAF00002273532 bam 8.0 GB
EGAF00002273533 bam 9.8 GB
EGAF00002273534 bam 10.0 GB
EGAF00002273535 bam 8.7 GB
EGAF00002273536 bam 7.8 GB
EGAF00002273537 bam 5.3 GB
EGAF00002273538 bam 5.2 GB
EGAF00002273539 bam 4.9 GB
EGAF00002273540 bam 8.2 GB
EGAF00002273541 bam 6.6 GB
EGAF00002273542 bam 6.7 GB
EGAF00002273543 bam 5.6 GB
EGAF00002273544 bam 5.8 GB
EGAF00002273545 bam 6.9 GB
EGAF00002273546 bam 8.3 GB
EGAF00002273547 bam 5.5 GB
EGAF00002273548 bam 5.8 GB
EGAF00002273549 bam 7.0 GB
EGAF00002273550 bam 6.2 GB
EGAF00002273551 bam 5.9 GB
EGAF00002273552 bam 7.2 GB
EGAF00002273553 bam 6.1 GB
EGAF00002273554 bam 6.9 GB
EGAF00002273555 bam 7.7 GB
EGAF00002273556 bam 8.9 GB
EGAF00002273557 bam 5.7 GB
EGAF00002273558 bam 7.4 GB
EGAF00002273559 bam 5.2 GB
EGAF00002273560 bam 7.8 GB
EGAF00002273561 bam 5.1 GB
EGAF00002273562 bam 8.9 GB
EGAF00002273563 bam 6.3 GB
EGAF00002273564 bam 6.9 GB
EGAF00002273565 bam 7.9 GB
EGAF00002273566 bam 5.6 GB
EGAF00002273567 bam 5.7 GB
EGAF00002273568 bam 5.7 GB
EGAF00002273569 bam 5.8 GB
EGAF00002273570 bam 5.2 GB
EGAF00002273571 bam 6.8 GB
EGAF00002273572 bam 5.5 GB
EGAF00002273573 bam 4.0 GB
EGAF00002273574 bam 7.3 GB
EGAF00002273575 bam 7.7 GB
EGAF00002273576 bam 4.5 GB
EGAF00002273577 bam 4.6 GB
EGAF00002273578 bam 3.4 GB
EGAF00002273579 bam 4.9 GB
EGAF00002273580 bam 4.4 GB
EGAF00002273581 bam 4.6 GB
EGAF00002273582 bam 4.6 GB
EGAF00002273583 bam 4.9 GB
EGAF00002273584 bam 4.5 GB
EGAF00002273585 bam 4.6 GB
EGAF00002273586 bam 4.7 GB
EGAF00002273587 bam 4.9 GB
EGAF00002273588 bam 124.1 GB
EGAF00002273589 bam 52.8 GB
EGAF00002273590 bam 110.6 GB
EGAF00002273591 bam 54.3 GB
EGAF00002273592 bam 100.3 GB
EGAF00002273593 bam 50.9 GB
EGAF00002273594 bam 128.1 GB
EGAF00002273595 bam 63.1 GB
EGAF00002273596 bam 124.8 GB
EGAF00002273597 bam 64.4 GB
EGAF00002273598 bam 118.8 GB
EGAF00002273599 bam 77.3 GB
EGAF00002273600 bam 116.1 GB
EGAF00002273601 bam 64.0 GB
EGAF00002273602 bam 834.0 MB
EGAF00002273603 bam 1.7 GB
EGAF00002273604 bam 1.6 GB
EGAF00002273605 bam 2.2 GB
EGAF00002273606 bam 824.3 MB
EGAF00002273607 bam 1.7 GB
EGAF00002273608 bam 2.5 GB
EGAF00002273609 bam 1.6 GB
EGAF00002273610 bam 2.4 GB
EGAF00002273611 bam 2.9 GB
EGAF00002273612 bam 1.8 GB
EGAF00002273613 bam 2.0 GB
EGAF00002273614 bam 2.1 GB
EGAF00002273615 bam 2.7 GB
EGAF00002273616 bam 1.8 GB
EGAF00002273617 bam 2.8 GB
EGAF00002273618 bam 2.5 GB
EGAF00002273619 bam 2.7 GB
EGAF00002273620 bam 2.6 GB
EGAF00002273621 bam 1.7 GB
EGAF00002273622 bam 2.1 GB
EGAF00002273623 bam 1.6 GB
EGAF00002273624 bam 3.0 GB
EGAF00002273625 bam 2.9 GB
EGAF00002273626 bam 2.3 GB
EGAF00002273627 bam 2.7 GB
EGAF00002273628 bam 1.9 GB
EGAF00002273629 bam 2.8 GB
EGAF00002273630 bam 1.7 GB
EGAF00002273631 bam 3.0 GB
EGAF00002273632 bam 2.7 GB
EGAF00002273633 bam 1.9 GB
EGAF00002273634 bam 1.6 GB
EGAF00002273635 bam 1.6 GB
EGAF00002273636 bam 2.3 GB
EGAF00002273637 bam 1.8 GB
EGAF00002273638 bam 2.8 GB
EGAF00002273639 bam 2.1 GB
EGAF00002273640 bam 2.0 GB
EGAF00002273641 bam 2.2 GB
EGAF00002273642 bam 1.5 GB
EGAF00002273643 bam 1.4 GB
EGAF00002273644 bam 1.5 GB
EGAF00002273645 bam 1.6 GB
EGAF00002273646 bam 1.9 GB
EGAF00002273647 bam 1.8 GB
EGAF00002273648 bam 1.8 GB
EGAF00002273649 bam 2.0 GB
EGAF00002273650 bam 1.3 GB
EGAF00002273651 bam 1.7 GB
EGAF00002273652 bam 1.7 GB
EGAF00002273653 bam 1.6 GB
EGAF00002273654 bam 1.4 GB
EGAF00002273655 bam 1.3 GB
EGAF00002273656 bam 1.6 GB
EGAF00002273657 bam 7.8 GB
EGAF00002273658 bam 8.5 GB
EGAF00002273659 bam 9.2 GB
EGAF00002273660 bam 15.9 GB
EGAF00002273661 bam 8.5 GB
EGAF00002273662 bam 19.3 GB
EGAF00002273663 bam 8.7 GB
EGAF00002273664 bam 15.8 GB
EGAF00002273665 bam 9.5 GB
EGAF00002273666 bam 15.6 GB
EGAF00002273667 bam 15.3 GB
EGAF00002273668 bam 8.8 GB
EGAF00002273669 bam 8.5 GB
EGAF00002273670 bam 13.5 GB
EGAF00002273671 bam 14.1 GB
EGAF00002273672 bam 9.9 GB
EGAF00002273673 bam 9.6 GB
EGAF00002273674 bam 9.3 GB
EGAF00002273675 bam 9.4 GB
EGAF00002273676 bam 8.8 GB
EGAF00002273677 bam 7.9 GB
EGAF00002273678 bam 10.5 GB
155 Files (2.0 TB)