Dataset

Genomic and transcriptomic determinants of therapy resistance and immune landscape evolution during anti-EGFR treatment in colorectal cancer

Dataset ID Technology Samples
EGAD00001004501 HiSeq X Ten,Illumina HiSeq 2000,Illumina HiSeq 2500 155

Dataset Description

Genomic and transcriptomic data from a cohort of 35 RAS wild-type colorectal cancers. All 35 cases were DNA sequenced at baseline (BL) before treatment with single agent cetuximab. Progressive disease (PD)-biopsies were taken shortly after radiological progression and successfully exome sequenced from 24/35 cases. mRNA sequencing is available for 25 Baseline and 15 PD samples. ctDNA from 9 cases that progressed after prolonged cetuximab benefit were also deep sequenced.

Who controls access to this dataset

For each dataset that requires controlled access, there is a corresponding Data Access Committee (DAC) who determine access permissions. Access to actual data files is not managed by the EGA. If you need to request access to this data set, please contact:

Translational Oncogenomics, ICR
Contact person: Dr Marco Gerlinger
Email: marco [dot] gerlinger [at] icr [dot] ac [dot] uk
More details: EGAC00001001092

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