DAC

Charite Berlin Paediatric Oncology Data Access Committee

Dac ID Contact Person Email Access Information
EGAC00001001766 Angelika Eggert angelika [dot] eggert [at] charite [dot] de No additional information is available

This DAC controls 4 datasets:

Dataset ID Description Technology Samples
EGAD00001008020 To investigate intratumour heterogeneity and to better understand tumour evolution in neuroblastoma, we have performed a multi-region whole-exome sequencing on a total of 51 spatially separated tumor samples from 9 primary neuroblastomas (2 low-risk, 1 intermediate-risk and 6 high-risk) and 1 relapsed neuroblastoma. We also assessed the impact of chemotherapy on the clonal expansion by sequencing tumour regions from one medium risk and one high-risk tumour for which we had matched samples obtained at diagnosis and after chemotherapy. Illumina HiSeq 4000 61
EGAD00001008133 To investigate intratumour heterogeneity and to better understand tumour evolution in neuroblastoma, we have performed a multi-region RNA sequencing on a total of 51 spatially separated tumor samples from 9 primary neuroblastomas (2 low-risk, 1 intermediate-risk and 6 high-risk) and 1 relapsed neuroblastoma. We also assessed the impact of chemotherapy on the clonal expansion by sequencing tumour regions from one medium risk and one high-risk tumour for which we had matched samples obtained at diagnosis and after chemotherapy. Illumina HiSeq 4000 50
EGAD00001008156 To investigate intratumour heterogeneity and to better understand tumour evolution in neuroblastoma, we have performed a multi-region targeted re-sequencing on a total of 140 samples from 9 primary neuroblastomas (2 low-risk, 1 intermediate-risk and 6 high-risk) and 2 relapsed neuroblastoma. Illumina HiSeq 4000 141
EGAD00010002225 SNP Array from CB1003 using Cytoscan HD, Thermo Fisher Scientific Cytoscan HD 3