MEDIOLA WOO Data Access Committee

Jiwon Koh
jwskoh@snu.ac.kr

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Dataset ID	Description	Technology	Samples
EGAD50000002906	Poly(A)-selected RNA sequencing of 160 fresh-frozen serial tumor biopsies from 54 patients with stage II/III triple-negative or ER-low breast cancer enrolled in the MEDIOLA window-of-opportunity trial (NCT03594396). Biopsies were obtained at baseline (n = 54), on day 14 after olaparib alone and before durvalumab (n = 54), and on day 29 after olaparib plus a single dose of durvalumab (n = 52). Libraries were prepared with the TruSeq Stranded mRNA LT kit and sequenced as paired-end reads on an Illumina NovaSeq 6000. The dataset comprises 320 paired-end FASTQ files (160 runs), encrypted with Crypt4GH.	Illumina NovaSeq 6000	160
EGAD50000002907	Whole-exome sequencing of baseline primary breast tumor biopsies and matched peripheral-blood germline DNA from 54 patients with stage II/III triple-negative or ER-low breast cancer enrolled in the MEDIOLA window-of-opportunity trial (NCT03594396), comprising 54 tumor-normal pairs. Exome libraries were prepared with the SureSelect V6 Post Capture Exome Kit and sequenced as 101-bp paired-end reads on an Illumina NovaSeq 6000. The dataset comprises 216 paired-end FASTQ files (108 runs), encrypted with Crypt4GH.	Illumina NovaSeq 6000	108