About file location

As the EGA is co-managed by the EMBL-EBI and CRG, files could be located in the UK and/or Spain, as indicated by their respective flags.

Alternatively, files could be located in one of the international Federated EGA nodes, as indicated next to the node's flag.
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MEDIOLA WOO baseline tumor and germline whole-exome sequencing (raw reads)

Whole-exome sequencing of baseline primary breast tumor biopsies and matched peripheral-blood germline DNA from 54 patients with stage II/III triple-negative or ER-low breast cancer enrolled in the MEDIOLA window-of-opportunity trial (NCT03594396), comprising 54 tumor-normal pairs. Exome libraries were prepared with the SureSelect V6 Post Capture Exome Kit and sequenced as 101-bp paired-end reads on an Illumina NovaSeq 6000. The dataset comprises 216 paired-end FASTQ files (108 runs), encrypted with Crypt4GH.

Request Access

DUO:0000006
version: 2021-02-23

health or medical or biomedical research

This data use permission indicates that use is allowed for health/medical/biomedical purposes; does not include the study of population origins or ancestry.

DUO:0000019
version: 2021-02-23

publication required

This data use modifier indicates that requestor agrees to make results of studies using the data available to the larger scientific community.

DUO:0000021
version: 2021-02-23

ethics approval required

This data use modifier indicates that the requestor must provide documentation of local IRB/ERB approval.

DUO:0000026
version: 2021-02-23

user specific restriction

This data use modifier indicates that use is limited to use by approved users.

DUO:0000046
version: 2021-02-23

non-commercial use only

This data use modifier indicates that use of the data is limited to not-for-profit use.

MEDIOLA WOO controlled-access data policy

This policy governs access to controlled-access human sequencing data generated by the MEDIOLA window-of-opportunity trial (ESR-16-11923; NCT03594396), a single-arm study of olaparib and durvalumab administered before standard neoadjuvant chemotherapy in patients with stage II/III triple-negative or ER-low breast cancer, conducted at Seoul National University Hospital, Seoul, Republic of Korea. The datasets comprise raw sequencing data (whole-exome sequencing of tumor and matched peripheral-blood germline samples, and RNA sequencing of serial tumor biopsies). Access is restricted to qualified researchers at recognized academic, non-profit, or research institutions, for non-commercial biomedical research consistent with the scope of the original participant consent and with the approvals granted by the Institutional Review Board of Seoul National University Hospital. Applicants must submit a data access request describing the intended research use, together with confirmation of relevant ethical approval at their own institution. Requests are reviewed by the MEDIOLA WOO Data Access Committee (EGAC50000001066). Approved users agree to the following conditions: to use the data solely for the research purpose stated in the approved application; to make no attempt to identify individual participants; not to transfer, share, or redistribute the data to any third party not named in the approved application; to maintain appropriate technical and organizational security measures; to acknowledge the data source and cite the original publication in any resulting work; to destroy the data upon completion of the approved project; and to publish or otherwise make publicly available the results of research conducted using these data.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS50000002019 Cancer Genomics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Quality Report
Located in
i
EGAF50000937216 fastq.gz 6.8 GB
EGAF50000937217 fastq.gz 6.6 GB
EGAF50000937220 fastq.gz 2.5 GB
EGAF50000937221 fastq.gz 2.7 GB
EGAF50000937222 fastq.gz 2.9 GB
EGAF50000937225 fastq.gz 3.1 GB
EGAF50000937226 fastq.gz 3.1 GB
EGAF50000937236 fastq.gz 7.9 GB
EGAF50000937237 fastq.gz 7.8 GB
EGAF50000937238 fastq.gz 6.7 GB
EGAF50000937239 fastq.gz 8.2 GB
EGAF50000937240 fastq.gz 8.1 GB
EGAF50000937241 fastq.gz 6.9 GB
EGAF50000937242 fastq.gz 7.9 GB
EGAF50000937243 fastq.gz 8.2 GB
EGAF50000937244 fastq.gz 7.8 GB
EGAF50000937245 fastq.gz 8.0 GB
EGAF50000937246 fastq.gz 7.1 GB
EGAF50000937247 fastq.gz 6.5 GB
EGAF50000937251 fastq.gz 6.7 GB
EGAF50000937253 fastq.gz 7.1 GB
EGAF50000937254 fastq.gz 7.2 GB
EGAF50000937255 fastq.gz 7.4 GB
EGAF50000937256 fastq.gz 6.9 GB
EGAF50000937257 fastq.gz 6.6 GB
EGAF50000937265 fastq.gz 2.9 GB
EGAF50000937267 fastq.gz 2.8 GB
EGAF50000937268 fastq.gz 2.8 GB
EGAF50000937271 fastq.gz 2.8 GB
EGAF50000937282 fastq.gz 2.9 GB
EGAF50000937283 fastq.gz 2.9 GB
EGAF50000937286 fastq.gz 2.8 GB
EGAF50000937287 fastq.gz 2.9 GB
EGAF50000937288 fastq.gz 2.6 GB
EGAF50000937289 fastq.gz 2.6 GB
EGAF50000937295 fastq.gz 9.0 GB
EGAF50000937305 fastq.gz 2.7 GB
EGAF50000937306 fastq.gz 9.1 GB
EGAF50000937319 fastq.gz 9.8 GB
EGAF50000937320 fastq.gz 10.0 GB
EGAF50000937321 fastq.gz 9.9 GB
EGAF50000937322 fastq.gz 2.7 GB
EGAF50000937325 fastq.gz 2.8 GB
EGAF50000937330 fastq.gz 2.6 GB
EGAF50000937334 fastq.gz 2.6 GB
EGAF50000937338 fastq.gz 2.7 GB
EGAF50000937344 fastq.gz 9.5 GB
EGAF50000937345 fastq.gz 8.9 GB
EGAF50000937348 fastq.gz 2.7 GB
EGAF50000937349 fastq.gz 8.8 GB
EGAF50000937356 fastq.gz 9.6 GB
EGAF50000937357 fastq.gz 7.6 GB
EGAF50000937362 fastq.gz 2.9 GB
EGAF50000937365 fastq.gz 2.9 GB
EGAF50000937366 fastq.gz 2.6 GB
EGAF50000937367 fastq.gz 2.7 GB
EGAF50000937368 fastq.gz 10.0 GB
EGAF50000937369 fastq.gz 10.2 GB
EGAF50000937371 fastq.gz 3.0 GB
EGAF50000937372 fastq.gz 2.9 GB
EGAF50000937373 fastq.gz 2.5 GB
EGAF50000937374 fastq.gz 2.5 GB
EGAF50000937375 fastq.gz 2.6 GB
EGAF50000937376 fastq.gz 2.5 GB
EGAF50000937377 fastq.gz 9.6 GB
EGAF50000937378 fastq.gz 9.3 GB
EGAF50000937379 fastq.gz 7.5 GB
EGAF50000937380 fastq.gz 7.6 GB
EGAF50000937387 fastq.gz 2.7 GB
EGAF50000937388 fastq.gz 2.8 GB
EGAF50000937389 fastq.gz 10.1 GB
EGAF50000937390 fastq.gz 10.3 GB
EGAF50000937391 fastq.gz 9.0 GB
EGAF50000937392 fastq.gz 10.0 GB
EGAF50000937393 fastq.gz 9.9 GB
EGAF50000937394 fastq.gz 9.0 GB
EGAF50000937395 fastq.gz 8.9 GB
EGAF50000937396 fastq.gz 9.1 GB
EGAF50000937397 fastq.gz 8.8 GB
EGAF50000937398 fastq.gz 9.0 GB
EGAF50000937399 fastq.gz 9.4 GB
EGAF50000937400 fastq.gz 9.6 GB
EGAF50000937401 fastq.gz 9.8 GB
EGAF50000937402 fastq.gz 9.6 GB
EGAF50000937403 fastq.gz 7.8 GB
EGAF50000937404 fastq.gz 8.0 GB
EGAF50000937405 fastq.gz 7.9 GB
EGAF50000937406 fastq.gz 10.0 GB
EGAF50000937407 fastq.gz 10.3 GB
EGAF50000937408 fastq.gz 8.1 GB
EGAF50000937409 fastq.gz 6.9 GB
EGAF50000937414 fastq.gz 3.0 GB
EGAF50000937415 fastq.gz 2.5 GB
EGAF50000937416 fastq.gz 2.6 GB
EGAF50000937417 fastq.gz 2.6 GB
EGAF50000937418 fastq.gz 2.2 GB
EGAF50000937419 fastq.gz 2.3 GB
EGAF50000937420 fastq.gz 2.5 GB
EGAF50000937421 fastq.gz 2.7 GB
EGAF50000937422 fastq.gz 7.2 GB
EGAF50000937423 fastq.gz 2.6 GB
EGAF50000937424 fastq.gz 2.7 GB
EGAF50000937425 fastq.gz 2.8 GB
EGAF50000937426 fastq.gz 2.4 GB
EGAF50000937427 fastq.gz 2.8 GB
EGAF50000937428 fastq.gz 6.8 GB
EGAF50000937429 fastq.gz 7.1 GB
EGAF50000937430 fastq.gz 7.4 GB
EGAF50000937431 fastq.gz 6.6 GB
EGAF50000937432 fastq.gz 6.8 GB
EGAF50000937433 fastq.gz 6.6 GB
EGAF50000937434 fastq.gz 7.0 GB
EGAF50000937435 fastq.gz 6.8 GB
EGAF50000937436 fastq.gz 7.2 GB
EGAF50000937437 fastq.gz 6.7 GB
EGAF50000937438 fastq.gz 6.8 GB
EGAF50000937439 fastq.gz 2.6 GB
EGAF50000937440 fastq.gz 3.1 GB
EGAF50000937441 fastq.gz 3.2 GB
EGAF50000937627 fastq.gz 3.0 GB
EGAF50000937628 fastq.gz 3.0 GB
EGAF50000937629 fastq.gz 2.8 GB
EGAF50000937630 fastq.gz 2.7 GB
EGAF50000937631 fastq.gz 2.5 GB
EGAF50000937632 fastq.gz 2.8 GB
EGAF50000937633 fastq.gz 2.9 GB
EGAF50000937634 fastq.gz 2.6 GB
EGAF50000937635 fastq.gz 3.2 GB
EGAF50000937636 fastq.gz 3.0 GB
EGAF50000937637 fastq.gz 3.1 GB
EGAF50000937638 fastq.gz 2.9 GB
EGAF50000937639 fastq.gz 2.7 GB
EGAF50000937640 fastq.gz 2.2 GB
EGAF50000937641 fastq.gz 2.3 GB
EGAF50000937642 fastq.gz 2.6 GB
EGAF50000937643 fastq.gz 2.7 GB
EGAF50000937644 fastq.gz 2.7 GB
EGAF50000937645 fastq.gz 2.8 GB
EGAF50000937646 fastq.gz 2.3 GB
EGAF50000937647 fastq.gz 2.4 GB
EGAF50000937648 fastq.gz 2.9 GB
EGAF50000937649 fastq.gz 2.9 GB
EGAF50000937650 fastq.gz 2.5 GB
EGAF50000937651 fastq.gz 2.6 GB
EGAF50000937652 fastq.gz 2.3 GB
EGAF50000937653 fastq.gz 2.3 GB
EGAF50000937654 fastq.gz 2.5 GB
EGAF50000937655 fastq.gz 2.5 GB
EGAF50000937656 fastq.gz 2.9 GB
EGAF50000937657 fastq.gz 3.0 GB
EGAF50000937658 fastq.gz 2.4 GB
EGAF50000937659 fastq.gz 2.4 GB
EGAF50000937660 fastq.gz 2.8 GB
EGAF50000937661 fastq.gz 2.5 GB
EGAF50000937662 fastq.gz 2.4 GB
EGAF50000937663 fastq.gz 2.5 GB
EGAF50000937664 fastq.gz 2.4 GB
EGAF50000937665 fastq.gz 2.6 GB
EGAF50000937666 fastq.gz 2.6 GB
EGAF50000937667 fastq.gz 2.6 GB
EGAF50000937668 fastq.gz 2.8 GB
EGAF50000937669 fastq.gz 2.8 GB
EGAF50000937670 fastq.gz 2.7 GB
EGAF50000937671 fastq.gz 2.8 GB
EGAF50000937672 fastq.gz 2.7 GB
EGAF50000937673 fastq.gz 2.7 GB
EGAF50000937674 fastq.gz 2.7 GB
EGAF50000937675 fastq.gz 8.9 GB
EGAF50000937676 fastq.gz 9.3 GB
EGAF50000937677 fastq.gz 9.5 GB
EGAF50000937678 fastq.gz 9.4 GB
EGAF50000937679 fastq.gz 9.9 GB
EGAF50000937680 fastq.gz 8.8 GB
EGAF50000937681 fastq.gz 8.9 GB
EGAF50000937682 fastq.gz 9.8 GB
EGAF50000937683 fastq.gz 9.8 GB
EGAF50000937684 fastq.gz 9.3 GB
EGAF50000937685 fastq.gz 9.5 GB
EGAF50000937686 fastq.gz 9.5 GB
EGAF50000937687 fastq.gz 9.7 GB
EGAF50000937688 fastq.gz 9.8 GB
EGAF50000937689 fastq.gz 8.6 GB
EGAF50000937690 fastq.gz 8.8 GB
EGAF50000937691 fastq.gz 9.3 GB
EGAF50000937692 fastq.gz 10.6 GB
EGAF50000937696 fastq.gz 2.9 GB
EGAF50000937697 fastq.gz 3.0 GB
EGAF50000937698 fastq.gz 6.8 GB
EGAF50000937699 fastq.gz 6.4 GB
EGAF50000937700 fastq.gz 6.6 GB
EGAF50000937701 fastq.gz 6.4 GB
EGAF50000937703 fastq.gz 7.2 GB
EGAF50000937705 fastq.gz 7.6 GB
EGAF50000937708 fastq.gz 7.8 GB
EGAF50000937709 fastq.gz 7.9 GB
EGAF50000937710 fastq.gz 8.1 GB
EGAF50000937711 fastq.gz 7.8 GB
EGAF50000937712 fastq.gz 8.0 GB
EGAF50000937713 fastq.gz 3.3 GB
EGAF50000937714 fastq.gz 3.4 GB
EGAF50000937715 fastq.gz 2.9 GB
EGAF50000937716 fastq.gz 3.0 GB
EGAF50000937717 fastq.gz 6.5 GB
EGAF50000937718 fastq.gz 6.8 GB
EGAF50000937722 fastq.gz 2.6 GB
EGAF50000937723 fastq.gz 7.5 GB
EGAF50000937724 fastq.gz 7.7 GB
EGAF50000937742 fastq.gz 2.9 GB
EGAF50000937743 fastq.gz 2.4 GB
EGAF50000937744 fastq.gz 2.4 GB
EGAF50000937745 fastq.gz 10.4 GB
EGAF50000937746 fastq.gz 7.8 GB
EGAF50000937747 fastq.gz 9.7 GB
EGAF50000937748 fastq.gz 9.4 GB
EGAF50000937749 fastq.gz 9.3 GB
EGAF50000937750 fastq.gz 9.2 GB
216 Files (1.2 TB)