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Genetic mechanisms of resistance to chemotherapy in breast cancer

Resistance towards chemotherapy is one of the main causes of treatment failure and deathamong breast cancer patients.The main objective of this project is toidentify genetic mechanisms causing some breast cancer patients not torespond to a particluar type of chemotherapy (epirubicin) while otherpatients respond very well to the same treatment. In the project wewill perform genome / exome sequencing of a selection of breast cancerpatients (n=30). These patients are drawn from a cohort where allpatients have recieved treatment with epirubicin monotherapy before surgical removal of alocally advanced breast tumour, and where all patients have beensubjected to objective evaluation of the response to thetherapy. Subsequent to sequencing, we will analyse the data andcompare with the clinical data for each patient (object response totherapy). The main aim being to identify mutations that are associatedwith resistance to epirubicin. Identification of mutations with strongpredictive value, may have a direct impact on cancer treatment sinceit opens the possibility for genetic testing of a tumour, and desicionon which drug is likely to work best, prior to treatment start.

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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001000276 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00000143716 bam 3.9 GB
EGAF00000143717 bam 4.1 GB
EGAF00000143718 bam 4.4 GB
EGAF00000143719 bam 3.9 GB
EGAF00000143720 bam 4.5 GB
EGAF00000143721 bam 4.6 GB
EGAF00000143722 bam 4.8 GB
EGAF00000143723 bam 4.7 GB
EGAF00000143724 bam 4.8 GB
EGAF00000143725 bam 4.7 GB
EGAF00000143726 bam 4.9 GB
EGAF00000143727 bam 5.1 GB
EGAF00000143728 bam 5.2 GB
EGAF00000143729 bam 3.6 GB
EGAF00000143730 bam 4.0 GB
EGAF00000143731 bam 3.3 GB
EGAF00000143732 bam 3.8 GB
EGAF00000143733 bam 3.8 GB
EGAF00000143734 bam 4.3 GB
EGAF00000143735 bam 4.0 GB
EGAF00000143736 bam 4.5 GB
EGAF00000143737 bam 3.6 GB
EGAF00000143738 bam 3.8 GB
EGAF00000143739 bam 4.1 GB
EGAF00000143740 bam 3.6 GB
EGAF00000143741 bam 4.2 GB
EGAF00000143742 bam 4.2 GB
EGAF00000143743 bam 4.5 GB
EGAF00000143744 bam 4.3 GB
EGAF00000143745 bam 4.5 GB
EGAF00000143746 bam 4.4 GB
EGAF00000143747 bam 4.5 GB
EGAF00000143748 bam 4.7 GB
EGAF00000143749 bam 4.8 GB
EGAF00000144803 bam 3.3 GB
EGAF00000144804 bam 3.6 GB
EGAF00000144805 bam 2.9 GB
EGAF00000144806 bam 3.4 GB
EGAF00000144807 bam 3.5 GB
EGAF00000144808 bam 3.9 GB
EGAF00000144809 bam 3.6 GB
EGAF00000144810 bam 4.1 GB
EGAF00000144811 bam 5.9 GB
EGAF00000144812 bam 7.1 GB
EGAF00000144813 bam 6.9 GB
EGAF00000144814 bam 7.1 GB
EGAF00000163574 bam 5.5 GB
EGAF00000163575 bam 3.6 GB
EGAF00000163576 bam 4.3 GB
EGAF00000163577 bam 6.7 GB
EGAF00000168652 bam 8.1 GB
EGAF00000168653 bam 5.3 GB
EGAF00000168654 bam 6.3 GB
EGAF00000168655 bam 9.8 GB
54 Files (251.0 GB)