Combination therapies for personalized cancer medicine

It is the ambition of the team formed by members of the Netherlands Cancer Institute (NKI) and the Cancer Genome Project at the Wellcome Trust Sanger Institute (WTSI) to unravel the genomic and phenotypic complexity of human cancers in order to identify optimal drug combinations for personalized cancer therapy. Our integrated approach will entail (i) deep sequencing of human tumours and cognate mouse tumours; (ii) drug screens in a 1000+ fully characterized tumour cell line panel; (iii) high-throughput in vitro and in vivo shRNA and cDNA drug resistance and enhancement screens; (iv) computational analysis of the acquired data, leading to significant response predictions; (v) rigorous validation of these predictions in genetically engineered mouse models and patient-derived xenografts. This integrated effort is expected to yield a number of combination therapies and companion-diagnostics biomarkers that will be further explored in our existing clinical trial networks.

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Studies are experimental investigations of a particular phenomenon. e.g. case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients. Click on one of the Study IDs below to find out more.

Study ID Study Title Study Type
EGAS00001000655 Cancer Genomics
ID File Type Size Located in Quality Control
EGAF00000559944 cram 319.3 MB
EGAF00000559945 cram 364.2 MB
EGAF00000559946 cram 335.3 MB
EGAF00000559947 cram 374.3 MB
EGAF00000559948 cram 382.6 MB
EGAF00000559949 cram 297.8 MB
EGAF00000559950 cram 508.6 MB
EGAF00000559951 cram 496.9 MB
EGAF00000559952 cram 275.3 MB
EGAF00000559953 cram 357.3 MB
EGAF00000559954 cram 329.2 MB
EGAF00000559955 cram 315.5 MB
EGAF00000559956 cram 515.3 MB
EGAF00000559957 cram 267.9 MB
EGAF00000559958 cram 343.4 MB
EGAF00000559959 cram 341.6 MB
EGAF00000559960 cram 325.0 MB
EGAF00000559961 cram 439.8 MB
EGAF00000559962 cram 352.9 MB
EGAF00000559963 cram 308.9 MB
EGAF00000559964 cram 345.6 MB
EGAF00000559965 cram 368.2 MB
EGAF00000559966 cram 390.8 MB
EGAF00000559967 cram 325.6 MB
EGAF00000559968 cram 244.4 MB
EGAF00000559969 cram 578.8 MB
EGAF00000559970 cram 403.2 MB
EGAF00000559971 cram 373.0 MB
EGAF00000559972 cram 391.8 MB
EGAF00000559973 cram 419.3 MB
EGAF00000559974 cram 454.6 MB
EGAF00000559975 cram 279.0 MB
EGAF00000559976 cram 243.8 MB
EGAF00000559977 cram 414.9 MB
EGAF00000559978 cram 342.3 MB
EGAF00000559979 cram 349.7 MB
EGAF00000559980 cram 337.9 MB
EGAF00000559981 cram 411.4 MB
EGAF00000559982 cram 288.6 MB
EGAF00000559983 cram 357.7 MB
EGAF00000559984 cram 344.7 MB
EGAF00000559985 cram 416.7 MB
EGAF00000559986 cram 214.1 kB
EGAF00000559987 cram 411.1 MB
EGAF00000559988 cram 447.4 MB
EGAF00000559989 cram 313.7 MB
EGAF00000559990 cram 312.4 MB
EGAF00000559991 cram 403.2 MB
EGAF00000559992 cram 437.6 MB
EGAF00000561985 cram 373.4 MB
EGAF00000561986 cram 426.5 MB
EGAF00000561987 cram 393.3 MB
EGAF00000561988 cram 442.7 MB
EGAF00000561989 cram 450.2 MB
EGAF00000561990 cram 349.1 MB
EGAF00000561991 cram 590.5 MB
EGAF00000561992 cram 580.6 MB
EGAF00000561993 cram 321.7 MB
EGAF00000561994 cram 422.5 MB
EGAF00000561995 cram 375.8 MB
EGAF00000561996 cram 372.1 MB
EGAF00000561997 cram 609.4 MB
EGAF00000561998 cram 317.3 MB
EGAF00000561999 cram 405.1 MB
EGAF00000562000 cram 402.5 MB
EGAF00000562001 cram 384.6 MB
EGAF00000562002 cram 522.0 MB
EGAF00000562003 cram 419.9 MB
EGAF00000562004 cram 365.1 MB
EGAF00000562005 cram 407.9 MB
EGAF00000562006 cram 438.2 MB
EGAF00000562007 cram 462.7 MB
EGAF00000562008 cram 385.3 MB
EGAF00000562009 cram 289.1 MB
EGAF00000562010 cram 682.1 MB
EGAF00000562011 cram 477.5 MB
EGAF00000562012 cram 437.3 MB
EGAF00000562013 cram 463.1 MB
EGAF00000562014 cram 499.0 MB
EGAF00000562015 cram 534.5 MB
EGAF00000562016 cram 328.5 MB
EGAF00000562017 cram 288.4 MB
EGAF00000562018 cram 488.3 MB
EGAF00000562019 cram 404.4 MB
EGAF00000562020 cram 409.2 MB
EGAF00000562021 cram 395.9 MB
EGAF00000562022 cram 485.1 MB
EGAF00000562023 cram 337.4 MB
EGAF00000562024 cram 416.5 MB
EGAF00000562025 cram 405.8 MB
EGAF00000562026 cram 491.6 MB
EGAF00000562027 cram 260.0 kB
EGAF00000562028 cram 479.7 MB
EGAF00000562029 cram 521.6 MB
EGAF00000562030 cram 369.1 MB
EGAF00000562031 cram 371.2 MB
EGAF00000562032 cram 477.9 MB
EGAF00000562033 cram 519.6 MB
EGAF00000562034 cram 372.6 MB
EGAF00000562035 cram 425.7 MB
EGAF00000562036 cram 392.2 MB
EGAF00000562037 cram 441.0 MB
EGAF00000562038 cram 448.5 MB
EGAF00000562039 cram 347.5 MB
EGAF00000562040 cram 590.2 MB
EGAF00000562041 cram 578.6 MB
EGAF00000562042 cram 320.5 MB
EGAF00000562043 cram 422.1 MB
EGAF00000562044 cram 374.6 MB
EGAF00000562045 cram 370.6 MB
EGAF00000562046 cram 608.3 MB
EGAF00000562047 cram 316.4 MB
EGAF00000562048 cram 404.4 MB
EGAF00000562049 cram 401.0 MB
EGAF00000562050 cram 383.2 MB
EGAF00000562051 cram 520.5 MB
EGAF00000562052 cram 417.6 MB
EGAF00000562053 cram 364.9 MB
EGAF00000562054 cram 407.3 MB
EGAF00000562055 cram 436.5 MB
EGAF00000562056 cram 460.7 MB
EGAF00000562057 cram 384.0 MB
EGAF00000562058 cram 288.7 MB
EGAF00000562059 cram 680.8 MB
EGAF00000562060 cram 475.9 MB
EGAF00000562061 cram 436.6 MB
EGAF00000562062 cram 461.3 MB
EGAF00000562063 cram 496.9 MB
EGAF00000562064 cram 532.3 MB
EGAF00000562065 cram 327.2 MB
EGAF00000562066 cram 287.6 MB
EGAF00000562067 cram 487.4 MB
EGAF00000562068 cram 402.7 MB
EGAF00000562069 cram 409.0 MB
EGAF00000562070 cram 396.5 MB
EGAF00000562071 cram 483.6 MB
EGAF00000562072 cram 338.3 MB
EGAF00000562073 cram 416.4 MB
EGAF00000562074 cram 404.8 MB
EGAF00000562075 cram 490.9 MB
EGAF00000562076 cram 258.1 kB
EGAF00000562077 cram 479.0 MB
EGAF00000562078 cram 519.2 MB
EGAF00000562079 cram 368.7 MB
EGAF00000562080 cram 370.5 MB
EGAF00000562081 cram 476.8 MB
EGAF00000562082 cram 518.1 MB
EGAF00001173882 cram 1.0 GB
EGAF00001173883 cram 644.4 MB
EGAF00001173884 cram 497.1 MB
EGAF00001173885 cram 745.7 MB
EGAF00001173886 cram 815.3 MB
EGAF00001173887 cram 406.1 MB
EGAF00001173888 cram 706.2 MB
EGAF00001173889 cram 705.1 MB
EGAF00001173890 cram 191.5 MB
EGAF00001173891 cram 316.1 MB
EGAF00001173892 cram 306.6 MB
EGAF00001173893 cram 463.3 MB
EGAF00001173894 cram 465.1 MB
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