Expression quantitative trait locus mapping in human pancreatic islets of Langerhans
The intersection of genome-wide association analyses with physiological and functional data indicates that variants regulating islet gene transcription influence type 2 diabetes (T2D) predisposition and glucose homeostasis. However, the specific genes through which these regulatory variants act remain poorly characterized. To identify such effector transcripts for T2D and glycemic traits, we generated expression quantitative trait locus (eQTL) data in 118 human islet samples using RNA-sequencing and high-density genotyping.
- 02/12/2015
- 118 samples
- DAC: EGAC00001000335
- Technology: Illumina HiSeq 2000
Oxford Human Islet Genotypes & RNA-seq Data Access Agreement
This agreement governs the terms on which access will be granted to the RNA-sequencing and genotype data generated as part of the “cis-eQTL mapping of human pancreatic islets” study.In signing this agreement, You are agreeing to be bound by the terms and conditions of access set out in this agreement.For the sake of clarity, the terms of access set out in this agreement apply both to the User and the User’s Institution (as defined below). User Institution and User are referred to within the agreement as “You” and “Your” shall be construed accordingly.Definitions:Investigators means the group of investigators based in Oxford, UK, and Edmonton, Canada, which have generated the Data.Data means all and any human genetic data obtained from the Investigators.Data Subject means a person, who has been informed of the purpose for which the Data is held and has given his/her informed consent thereto.User means a researcher whose User Institution has previously completed this Data Access Agreement and has received acknowledgement of its acceptance.Publications means, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research.User Institution means the organisation at which the User is employed, affiliated or enrolled.Terms and Conditions: In signing this Agreement:1. 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You accept that the Investigators, the original data creators, depositors or copyright holders, or the funders of the Data or any part of the Data supplied:a. bear no legal responsibility for the accuracy or comprehensiveness of the Data; andb. accept no liability for indirect, consequential, or incidental, damages or losses arising from use of the Data, or from the unavailability of, or break in access to, the Data for whatever reason.9. You understand and acknowledge that the Data is protected by copyright and other intellectual property rights, and that duplication, except as reasonably required to carry out Your research with the Data, or sale of all or part of the Data on any media is not permitted.10. You recognise that nothing in this agreement shall operate to transfer to the User Institution any intellectual property rights relating to the Data. The User Institution has the right to develop intellectual property based on comparisons with their own data.11. You accept that this agreement will terminate immediately upon any breach of this agreement by You and You will be required to destroy any Data held.12. You accept that it may be necessary for the Investigators or its appointed agent to alter the terms of this agreement from time to time in order to address new concerns. In this event, the Investigators or its appointed agent will contact You to inform You of any changes and You agree that Your continued use of the Data shall be dependent on the parties entering into a new version of the Agreement.13. You accept that the Data is protected by and subject to international laws, including but not limited to the UK Data Protection Act 1998, and that You are responsible for ensuring compliance with any such applicable law. The Oxford Human Islet Data Access Committee reserves the right to request and inspect data security and management documentation to ensure the adequacy of data protection measures in countries that have no national laws comparable to that which pertain in the EAA.14. This agreement shall be construed, interpreted and governed by the laws of England and Wales and shall be subject to the non-exclusive jurisdiction of the English courts.
Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.
Study ID | Study Title | Study Type |
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EGAS00001001265 | Metagenomics |
- uploaded a covariates file for the 118 samples
- Dataset Released
This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.