Targeted sequencing of 72 prostate cancer driver in 712 plasma cell free DNA samples

Dataset ID Technology Samples
EGAD00001004208 Illumina HiSeq 2500 1140

Dataset Description

Dataset contains targeted sequencing data of 712 plasma cell free DNA samples and 428 white blood cell samples collected from 428 men with metastatic prostate cancer. Target capture was performed using a hydridization-based custom Roche SeqCap EZ Choice kit, designed to capture all exons of 72 prostate cancer driver genes. Cell free DNA was extracted from 10 mL blood samples. Libraries were sequenced using Illumina HiSeq 2500 or Illumina MiSeq instruments to a median coverage of 750x. 62% of samples had ctDNA fraction above 2% of total cfDNA.

Note that "Dataset type" is erroneously listed as "Amplicon sequencing", because "Captured-based targeted sequencing" or "Hybridization-based targeted sequencing" were not available options in EGA at the time of submission.

Who controls access to this dataset

For each dataset that requires controlled access, there is a corresponding Data Access Committee (DAC) who determine access permissions. Access to actual data files is not managed by the EGA. If you need to request access to this data set, please contact:

DAC for study: Frequent mutation of the FOXA1 untranslated region in prostate cancer
Contact person: Alexander Wyatt
Email: awyatt [at] prostatecentre [dot] com
More details: EGAC00001000962


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