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DDD DATAFREEZE 2017-12-15: 13,462 trios and probands only - exome sequence CRAM files

DDD DATAFREEZE 2017-12-15: 13,462 trios and probands only - exome sequence CRAM files

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Policy and DAC for Deciphering Developmental Disorders (DDD)

Wellcome Trust Sanger InstituteDATA ACCESS AGREEMENTFebruary 2011 v2Application for Access to DataI would like to apply for access to the following Deciphering Developmental Disorders (DDD) data sets (tick all that apply):[Data set names/IDs: ______________ ______________ ______________ ] I - Contact and Project Information (to be submitted by applicant)A. Name of applicant (principal investigator), including affiliation and contact details.Please ensure that a full postal address and a valid institutional email are included.Name:Title:Position:Affiliation:Institutional E-mail Address:Mailing Address:B. Name of the authorised institutional representative, including affiliation and contact details.Please ensure that a full postal address and a valid institutional email are included.Name:Title:Position:Affiliation:Institutional E-mail Address:Mailing Address:C. Names of authorised personnel (within your institution*)Include the names of all investigators, collaborators and research staff who will have accessto the data in order to work on the project (see Research Project under E). Pleaseensure that a valid institutional email address for each name is included along with their jobtitle/function.*Co-investigators or collaborators at other institutions must submit a separate Application for Access to the Data.Name: (copy and paste as needed for additional personnel)Title:Position:Affiliation:Institutional E-mail Address:D. Names of authorised students (within your institution*)Include the names of all students who will have access to the data in order to workon the project (see Research Project under E). Please ensure that a valid email address foreach name is included.*Students at other institutions should not be included in this list.Name: (copy and paste as needed for additional students)Title:Position:Affiliation:Institutional E-mail Address:E. Title of project (within which data will be used)Please provide the address of the project website as well, if availableF. Research track recordInclude a list of up to 3 relevant publications of which you were an author or a co-author.G. Research Project (scientific abstract)Please provide a clear description of the project and its specific aims, including an explanation of the role the accessed data will play in answering the research question, in no more than 500words. II – Data SecurityWe ask that you provide a level of security similar to that described below when storing and using the data you have applied for.File access: Data should only be accessible to named users. Files should either have only user Unix read/write access, not group or world access, or project-specific Unix groups should be used for group access that contain only those names authorised to access the data. User IDs within groups should be reviewed at 6 monthly intervals by the applicant. Data kept on laptops should be encrypted when not in active use, either in individual encrypted files or in encrypted directories/partitions. Data should not be held on USB keys or other portable hard drives. Users may be asked to sign an agreement addressing their responsibilities with respect to access to such data. III - DATA ACCESS AGREEMENTThis Data Access Agreement governs the terms of access to the managed access datasets generated by the Wellcome Trust Sanger Institute (WTSI) and NHS Regional Genetics Services (RGS) collaborators (the “Data” as defined below). In signing this agreement, you agree to be bound by the terms and conditions of access set out therein. For the sake of clarity, the terms of access set out in this agreement apply to the User and to the User Institution(s) (as defined below).DefinitionsData: The managed access datasets of the DDD Project Data Producer(s): The WTSI and NHS RGS collaborators responsible for the development, organisation, and oversight of the Data.External Collaborator: A collaborator of the User, working for an institution other than the User Institution(s) (see below for definitions of User and User Institution(s)).Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research.Research Participant: An individual having contributed data for research purposes.Research Purposes: shall mean research that is seeking to advance the understanding of the genetic causation of the undiagnosed developmental disorder in each family.User: An applicant (principal investigator), having signed this Data Access Agreement, whose User Institution has co-signed this Data Access Agreement, both of them having received acknowledgement of its acceptance.User Institution(s): Institution(s) at which the User is employed, affiliated or enrolled. A representative of it has co-signed this Data Access Agreement with the User and received acknowledgement of its acceptance.Terms and Conditions:In signing this agreement:1. The User and the User Institution(s) agree to only use the Data for Research Purposes and specifically only for the objectives and analyses outlined in section G. “Research Project”. 2. The User and the User Institution(s) agree to preserve, at all times, the confidentiality of the Data. In particular, they undertake not to use, or attempt to use the Data to compromise or otherwise infringe the confidentiality of information on Research Participants.3. The User and the User Institution(s) agree to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification.4. The User and the User Institution(s) agree not to link or combine the Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User and the User Institution(s), or is freely available without restriction.5. The User and the User Institution(s) agree not to transfer or disclose the Data, in whole or part, or any material derived from the Data, to anyone not listed in section C “Names of authorised personnel” or D “Names of authorised students” of this application form, except as necessary for data safety monitoring, national audits or programme management. Should the User or the User Institution(s) wish to share the Data with an External Collaborator, the External Collaborator must complete a separate Application for Access to the Data.6. The User and the User Institution(s) agree that Genome Research Limited, the Data producers, and all other parties involved in the creation, funding or protection of the Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of the Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of the Data or from the unavailability of, or break in access to, the Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data.7. The User and the User Institution(s) agree to follow the Fort Lauderdale Guidelinesincluded as Appendix I of this agreement and the Toronto Statement included as Appendix II of this agreement. This includes but is not limited to recognizing the contribution of the Data Producer(s) and including a proper acknowledgement in all reports or publications resulting from the User and the User Institutions use of the Data.8. The User and the User Institution(s) agree to follow the Publication Policy available as Appendix III of this agreement. This includes respecting the moratorium period for Data Producers to publish the first peer-review report(s) describing and analyzing the Data. The publication moratorium lasts for one year from the time at which data was first made available.9. The User and the User Institution(s) agree not to make intellectual property claims on the Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of the Data, or conclusion drawn directly from the Data.10. The User and the User Institution(s) can elect to perform further research that would add intellectual and resource capital to the data and decide to obtain intellectual property rights on these downstream discoveries. In this case, the User and the User Institution(s) agree to implement licensing policies that will not obstruct further research and to follow the U.S. National Institutes of Health Best Practices for the Licensing of Genomic Inventions (2005) in conformity with the Organisation for Economic Co-operation and Development Guidelines for the Licensing of the Genetic Inventions (2006). These two policies (NIH and OECD) are included as Appendix IV and V of this agreement.11. The Data was funded by the Wellcome Trust with the charitable objective of improving health. If results arising from the User and the User Institution(s) use of the Data could provide health solutions for the benefit of people in the developing world, the User and the User Institution(s) agree to offer non-exclusive licenses to such results on a reasonable basis for use in low income and low-middle income countries (as defined by the World Bank) to any party that requests such a license solely for uses within these territories.12. The User and the User Institution(s) agree to destroy/discard the Data held, once it is no longer used for the project described in this application form, unless obligated to retain the data for archival purposes in conformity with national audits or legal requirements.13. The User and the User Institution(s) will update the List of Authorized Personnel to reflect any changes or departures in researchers, collaborators and personnel within 30 days of the changes made.14. The User and the User Institution(s) must notify the Data Producer(s) prior to any significant changes to the protocol of the User (as described in section I.G. “Research Project”). 15. The User and the User Institution(s) will notify the Data Producer(s) as soon as they become aware of a breach of the terms or conditions of this agreement.16. The User and the User Institution(s) accept that this agreement may terminate upon any breach of this agreement from the User, the User Institution(s) or any authorised personnel mentioned in section C. “Names of authorised personnel” or D. “Names of authorised students” of this application document. In this case, The User and the User Institution(s) will be required to destroy/discard any Data held, including copies and backup copies. This clause does not prevent the User and the User Institution(s) from retaining the data for archival purpose in conformity with national audits or legal requirements.17. The User and the User Institution(s) accept that it may be necessary for the Data Producer(s) or their appointed agent to alter the terms of this agreement from time to time. In this event, the Data Producer(s) or their appointed agent will contact the User and the User Institution(s) to inform them of any changes.18. If requested, the User and the User Institution(s) will allow data security and management documentation to be inspected to verify that they are complying with the terms of this agreement.19. The User and the User Institution(s) agree to distribute a copy of this agreement and explain its content to any person mentioned in section C. “Names of authorised personnel” and D. “Names of authorised students section of this application form.20. This agreement (and any dispute, controversy, proceedings or claim of whatever nature arising out of this agreement or its formation) shall be construed, interpreted and governed by the laws of England and Wales and shall be subject to the exclusive jurisdiction of the English courts. I have read and agree to abide by the terms and conditions outlined in the Data Access Agreement. YES (please circle on paper copy)I have read the Appendices listed at the end of this page. YES (please circle on paper copy)Applicant:Name ____________________________(block letters)Title and position ___________________Institution _________________________Signature _____________________Authorized institutional representative:(He/she should be the same person as mentioned under Section I B. InstitutionalRepresentative of this data application document):Name ____________________________(blocks letters)Title and position ___________________Institution ________________________(name of legal entity) Signature______________________Authorized institutional representative of the Data Producer(s):I attest that the above is in conformity with the access requirements of the DDD Project:Name _____________________________ (block letters)Signature ___________________________Approval number _____________________Once completed and sent electronically to wtsidata1@sanger.ac.uk, a paper copy of this application must be faxed to +44 (0) 1223 49 6802 or mailed to Dr. Tim HubbardWellcome Trust Sanger InsituteWellcome Trust Genome CampusHinxton, CambridgeCB10 1SAUKOnly the paper copy needs to be signed. Appendices do not need to be sent back.APPENDIX I – SHARING DATA FROM LARGE-SCALE BIOLOGICAL RESEARCH PROJECTS: A SYSTEM OF TRIPARTITE RESPONSIBILTY “THE FORT LAUDERDALE GUIDELINES” (2003)APPENDIX II – “THE TORONTO STATEMENT” (2009)APPENDIX III – PUBLICATION POLICY APPENDIX IV - NIH, BEST PRACTICES FOR THE LICENSING OF GENOMIC INVENTIONS (2005)APPENDIX V - OECD, GUIDELINES FOR THE LICENSING OF GENETIC INVENTIONS (2006)APPENDIX I – SHARING DATA FROM LARGE-SCALE BIOLOGICAL RESEARCH PROJECTS: A SYSTEM OF TRIPARTITE RESPONSIBILTY “THE FORT LAUDERDALE GUIDELINES” (2003)Sharing Data from Large-scale Biological Research Projects: A System of Tripartite ResponsibilityReport of a meeting organized by the Wellcome Trust and held on 14–15 January 2003 at Fort Lauderdale, USA.IntroductionThe Wellcome Trust sponsored a meeting on 14–15 January 2003 to discuss how, at this point in the development of the field of genomics, pre-publication data release can promote the best interests of science and help to maximize the public benefit to be gained from research. About 40 people attended the meeting, among them large-scale sequence producers, sequence users including computational biologists, representatives of the major nucleotide sequence databases, journal editors, and scientists interested in other large-scale data sets. The discussion took as a given that published data are available in their entirety for any use by any investigator, and focused on issues involved in making data broadly available prior to publication. The meeting concluded that pre-publication release of sequence data by the International Human Genome Sequencing Consortium, and other sequence producers, has been of tremendous benefit to the scientific research community in general. While not all were in a position to make commitments for their funding agencies, the meeting attendees were in broad agreement that, to encourage the continuation of such benefits, the sequence producers, sequence users and the funding agencies recognize and implement a system based on ‘tripartite responsibility’.Specifically,•The meeting attendees enthusiastically reaffirmed the 1996 Bermuda Principles, which expressly called for rapid release to the public international DNA sequence databases (GenBank, EMBL, and DDBJ) of sequence assemblies of 2kb or greater by large-scale sequencing efforts and recommended that that agreement be extended to apply to all sequence data, including both the raw traces submitted to the Trace Repositories at NCBI and Ensembl and whole genome shotgun assemblies.•The attendees recommended that the principle of rapid pre-publication release should apply to other types of data from other large-scale production centers specifically established as ‘community resource projects’.•The attendees recognized that pre-publication data release might conflict with a fundamental scientific incentive – publishing the first analysis of one's own data. The attendees noted that it would not be possible to absolutely guarantee this incentive without applying restrictions that would undermine the rationale for rapid, unrestricted release of data from community resources. Nonetheless, it is essential that excellent scientists continue to be attracted to these projects. To encourage this, the scientific community should understand that pre-publication data release needs active communitywide support if it is to continue to receive widespread support from the producers. The contributions and interests of the large-scale data producers should be recognized and respected by the users of the data, and the ability of the production centres to analyse and publish their own data should be supported by their funding agencies.Community resource projectsA ‘community resource project’ is a research project specifically devised and implemented to create a set of data, reagents or other material whose primary utility will be as a resource for the broad scientific community. Recent examples of community resource projects include the International Human Genome Sequencing Consortium, the Mouse Genome Sequencing Consortium, the Mammalian Gene Collection, the SNPs Consortium, and the International HapMap Project. The products of community resource projects have, over the past several years, become increasingly important as drivers of progress in biomedical research. The scientific community will best be served if the results of community resource projects are made immediately available for free and unrestricted use by the scientific community to engage in the full range of opportunities for creative science. At the same time, it is crucial that the scientific community recognizes and respects the important contribution made by the scientists who carry out community resource projects.Tripartite sharing of responsibilityAn optimized system for generating community resources involves three constituencies within the scientific research community – resource producers, resource users, and funding agencies. Each of the three has a unique and critical role to play in ensuring the growth and development of the community resource system.A. Funding agencies. Funding agencies are the major sources of support of research projects leading to community resources and projects that depend on the availability of such resources. Funding agencies have a critical role in determining the quality and breadth of community resources through the peer review evaluation system and as the sources of scientific research policies. For these reasons funding agencies should:1.designate appropriate efforts as community resource projects, and encourage resource producers to prepare and submit Project Descriptions (see below) for publication;2.require, as a condition of funding, free and unrestricted data release from community resource projects to appropriate central and searchable public databases, and vigorously ensure that this occurs;3.encourage more investigators to serve the community through involvement in such projects. In particular, the agencies should ensure that investigators engaged in generation of such datasets have sufficient support for curation, maintenance and distribution of the data to the community, as well as resources to perform initial analyses using the resources that they have generated;4.ensure that a centralized view of existing community resource projects is available as an information source for the community;5.support central databases that will house and distribute the data in a way that prevents fragmentation of the data.B. Resource producers. Community resources are often expensive efforts. For this and other reasons, they are frequently established and supported as unique facilities. The scientists who organize and operate community resources are, accordingly, in a uniquely responsible position. The community is dependent on the success of their efforts and they often face relatively little direct competition. Resource producers should:1.when feasible, publish a Project Description. The purpose of the Project Description, which will be a new type of scientific publication, is to inform the scientific community about the resource project and to provide a citation to reference the source of the data. The Project Description should be written at the beginning of the project and describes the plans for and scope of the production and analyses that the data producer intends to undertake. It will often include a timeline for production goals and data release.2.produce data of consistently high quality;3.make the data generated by the resource immediately and freely available without restriction;4.recognize that even if the resource is occasionally used in ways that violate normal standards of scientific etiquette, this is a necessary risk set against the considerable benefits of immediate data release.C. Resource Users. Community resource data sets benefit the users enormously, giving them the opportunity to analyse the data without the need to generate it first. The data sets are, in general, much larger, richer and of higher quality than individual laboratories could normally generate. In contributing to what ideally is a symbiotic and synergistic situation, resource users should:1.appropriately cite the source of the data analysed and acknowledge the resource producers. The early publication of a Project Description, as suggested above, would provide users with an appropriate reference to cite before the data are formally published;2.recognize that the resource producers have a legitimate interest in publishing prominent peer-reviewed reports describing and analyzing the resource that they have produced (and that neither the Project Descriptions nor data deposits in databases are the equivalent of such publications);3.respect the producer’s legitimate interests as set out, e.g. in a Project Description, while being free to use the data in any creative way. There should be no restrictions on the use of the data, but the best interests of the community are served when all act responsibly to promote the highest standards of respect for the scientific contribution of others. In some cases, this might best be done by discussion or coordination with the resource producers;4.assist journals and funding agencies to play their proper roles in ensuring, through the peer review system, that the system works fairly for all constituents.Large-scale genome sequencingLarge-scale genome sequencing projects are clearly community resource projects, and serve as a well-developed example to illustrate the general principles described above. The Bermuda Principles (http://www.gene.ucl.ac.uk/hugo/bermuda.htm) were developed in 1996 by the scientists engaged in the International Human Genome Sequencing Consortium and their funding agencies, and have been the basis of a successful system for achieving rapid and open data release. Now, in 2003, the meeting attendees, recognizing the role of users as well as producers and funders in effecting a successful system, enthusiastically recommend the reaffirmation of the Bermuda Principles for continued large-scale sequencing projects, and recommend that:1.They should be extended beyond their initial application to sequence assemblies of a minimum size from BAC-based sequence projects so that they apply to rapid (i.e. as soon as possible) release of both raw and assembled sequence data, subject only to the data meeting appropriate quality assessment standards.2.Funding agencies, users and sequencing centers should all honor their obligations, as described above.Other community resource projectsIn the near future, many other large data sets will be produced as community resources.While only a few of the meeting attendees were familiar with data types other than large-scale sequences, the attendees recommended that appropriate implementation of the principles discussed should be devised for other community resource projects, such as large-scale protein structure determination or gene expression analysis. In many of these cases, the solutions, in terms of such considerations as data quality standards, data storage and dissemination modes, and producer and user interests, are only beginning to emerge. Development of effective systems for achieving the objectives of the community resource concept should be an integral component of the planning and development of such new community resources.Research materials and toolsSome of the issues involved in ensuring rapid and open access to finite resources, such as reagents, clones, cell lines and other material resources, are different from those pertaining to electronic data sets. The meeting attendees strongly encouraged the relevant funding agencies, resource producers and users to develop practical approaches to maximizing the benefit of this type of resource to the scientific community and to research.Pre-publication release of other dataBeyond community resource projects, many valuable data sets could come from other sources.Still different issues arise in the case of resources that emerge from research efforts whose primary goal is not resource generation. In such cases, contribution of the data to the public domain as a resource is more a voluntary matter. To obtain the clear benefit that would ensue from converting such data sets into community resources as rapidly as possible, incentives should be developed by the scientific community to support the voluntary release of such data prior to publication, by appropriately recognizing and protecting the interests of scientists who wish to share such pre-publication data with the community. APPENDIX II – “THE TORONTO STATEMENT” (2009)The full article, Prepublication data sharing, Nature, 461: 168-70 (2009), is available at: http://www.nature.com/nature/journal/v461/n7261/full/461168a.htmlRapid pre-publication data release should be encouraged for projects with the following attributes:● Large scale (requiring significant resources over time)● Broad utility● Creating reference data sets● Associated with community buy-inFunding agencies should facilitate the specification of data-release policies for relevant projects by:● Explicitly informing applicants of data-release requirements, especially mandatory prepublication data release● Ensuring that evaluation of data release plans is part of the peer review process● Proactively establishing analysis plans and timelines for projects releasing data pre-publication● Fostering investigator-initiated pre-publication data release● Helping to develop appropriate consent, security, access and governance mechanisms that protect research participants while encouraging pre-publication data release● Providing long-term support of databasesData producers should state their intentions and enable analyses of their data by:● Informing data users about the data being generated, data standards and quality, planned analyses, timelines, and relevant contact information, ideally through publication of a citeable marker paper near the start of the project or by provision of a citable URL at the project or funding agency website● Providing relevant metadata (e.g., questionnaires, phenotypes, environmental conditions, and laboratory methods) that will assist other researchers in reproducing and/or independently analyzing the data, while protecting interests of individuals enrolled in studies focusing on humans● Ensuring that research participants are informed that their data will be shared with other scientists in the research community● Publishing their initial global analyses, as stated in the marker paper or citable URL, in a timely fashion● Creating databases designed to archive all data (including underlying raw data) in an easily retrievable form and facilitate usage of both pre-processed and processed dataData analysts/users should freely analyze released prepublication data and act responsibly in publishing analyses of those data by:● Respecting the scientific etiquette that allows data producers to publish the first global analyses of their data set● Reading the citeable document associated with the project● Accurately and completely citing the source of prepublication data, including the version of the data set (if appropriate)● Being aware that released pre-publication data may be associated with quality issues that will be later rectified by the data producers● Contacting the data producers to discuss publication plans in the case of overlap between planned analyses● Ensuring that use of data does not harm research participants and is in conformity with ethical approvalsScientific journal editors should engage the research community about issues related to prepublication data release and provide guidance to authors and reviewers on the third-party use of pre-publication data in manuscripts APPENDIX III – PUBLICATION POLICY We are committed to the principles of rapid data release. We intend to publish the results of our analysis of this data set and do not consider its deposition into public databases to be the equivalent of such publications. We anticipate that the data set could be useful to other qualified researchers for a variety of purposes, however, some areas of work are therefore subject to a publication moratorium which will last for one year from the time at which data was first made available (please check the run submission date).The publication moratorium covers any publications (including oral communications) that describe the use of the data set for investigations related to the phenotype for which samples were selected. For research papers, this means that submission for publication should not occur until 12 months have passed since data was first made available. Researchers should make reasonable efforts to ensure that the publication of data will not have adverse effects on families included in the dataset.Please acknowledge the use of this data set as follows in any publications based on it:“The DDD study presents independent research commissioned by the Health Innovation Challenge Fund [grant number HICF-1009-003], a parallel funding partnership between the Wellcome Trust and the Department of Health, and the Wellcome Trust Sanger Institute [grant number WT098051]. The views expressed in this publication are those of the author(s) and not necessarily those of the Wellcome Trust or the Department of Health. The study has UK Research Ethics Committee approval (10/H0305/83, granted by the Cambridge South REC, and GEN/284/12 granted by the Republic of Ireland REC). The research team acknowledges the support of the National Institute for Health Research, through the Comprehensive Clinical Research Network.”Please contact wtsidata1@sanger.ac.uk if you are in any doubt about the restrictions described here. APPENDIX IV - NIH, BEST PRACTICES FOR THE LICENSING OF GENOMIC INVENTIONS (2005)DEPARTMENT OF HEALTH AND HUMAN SERVICESNational Institutes of HealthBest Practices for the Licensing of Genomic Inventions: Final NoticeFederal Register / Vol. 70, No. 68 / Monday, April 11, 2005 / Notices (p18413)(for supplementary information, please see the original publication)IntroductionThe Public Health Service’s (PHS) primary mission is to acquire new knowledge through the conduct and support of biomedical research to improve the health of the American people. This mission is advanced by the intramural research efforts of government-owned and –operated laboratories and by the extramural research efforts funded through grants and contracts. PHS seeks to maximize the public benefit whenever PHS owned or funded technologies are transferred to the commercial sector. Motivated by this goal, we offer the following best practices for the licensing of government-funded genomic inventions.Genomic inventions include a wide array of technologies and materials such as cDNAs; expressed sequence tags (ESTs); haplotypes; antisense molecules; small interfering RNAs (siRNAs); fulllength genes and their expression products; as well as methods and instrumentation for the sequencing of genomes, quantification of nucleic acid molecules, detection of single nucleotide polymorphisms (SNPs), and genetic modifications. Much of the value associated with the commercial use of these technologies involves nucleic acid-based diagnostics, potential gene therapy applications, and the development of new DNA and RNAbased therapeutics.BackgroundAmong the benefits derived from PHS conducted and supported biomedical research are effective and accessible new healthcare treatments and services. Practical realization of these benefits depends on the ability and willingness of private sector partners to develop and commercialize new technologies arising from PHS conducted and funded research. For potential preventive, diagnostic, and therapeutic products, the interest of the private sector in commercializing new technologies often depends on the existence of patent protection on the technology in the United States and foreign countries.The Bayh-Dole Act of 1980 allows PHS grantees and contractors to seek patent protection on subject inventions made using Government funds and to license those inventions with the goal of promoting their utilization, commercialization, and public availability. Recipients of PHS grants and contracts have a role in implementing the requirements of the Bayh-Dole Act (https://sedison.info.nih.gov/iEdison). In 1986,Federal laboratories, including PHS research laboratories at the National Institutes of Health (NIH), the Food and Drug Administration (FDA), and the Centers for Disease Control and Prevention (CDC), were given a statutory mandate under the Federal Technology Transfer Act (P.L. 99–502) and Executive Order 12591 to ensure that new technologies developed in those laboratories were transferred to the private sector and commercialized.PHS recognizes that patenting and licensing genomic inventions presents formidable challenges for academic and government technology transfer programs because of the complexities in bringing these technologies to the marketplace in a way that balances the expansion of knowledge and direct public health benefit with the commercial needs of private interests.The following represents best practices recommendations to the intramural PHS technology transfer community as well as to universities, hospitals and other non-profit PHS funding recipients. These recommendations are not intended to constitute additional regulations, guidelines or conditions of award for any contract or grant, although they are consistent with existing policies set out in Sharing Biomedical Research Resources (http://ott.od.nih.gov/NewPages/RTguide_final.html) and Developing Sponsored Research Agreements (http://ott.od.nih.gov/spons_research.html).Patent ProtectionLike other emerging technology areas, patents directed to genomic inventions tend to issue with claims that are broad in scope. Public health-oriented technology transfer must balance the rewards of broad intellectual property protection afforded to founders of enabling genomic inventions with the benefits of fostering opportunities for those striving to improve upon those innovations.Therefore, in considering whether to seek patent protection on genomic inventions, institutional officials should consider whether significant further research and development by the private sector is required to bring the invention to practical and commercial application. Intellectual property protection should be sought when it is clear that private sector investment will be necessary to develop and make the invention widely available. By contrast, when significant further research and development investment is not required, such as with many research material and research tool technologies, best practices dictate that patent protection rarely should be sought.Best Licensing PracticesThe optimal strategy to transfer and commercialize many genomic inventions is not always apparent at early stages of technology development. As an initial step in these instances, it may be prudent to protect the intellectual property rights to the invention. As definitive commercial pathways unfold, those embodiments of an invention requiring exclusive licensing as an incentive for commercial development of products or services can be distinguished from those that would best be disseminated non-exclusively in the marketplace.Whenever possible, non-exclusive licensing should be pursued as a best practice. A non-exclusive licensing approach favors and facilitates making broad enabling technologies and research uses of inventions widely available and accessible to the scientific community. When a genomic invention represents a component part or background to a commercial development, non-exclusive freedom-tooperate licensing may provide an appropriate and sufficient complement to existing exclusive intellectual property rights.In those cases where exclusive licensing is necessary to encourage research and development by private partners, best practices dictate that exclusive licenses should be appropriately tailored to ensure expeditious development of as many aspects of the technology as possible. Specific indications, fields of use, and territories should be limited to be commensurate with the abilities and commitment of licensees to bring the technology to market expeditiously.For example, patent claims to gene sequences could be licensed exclusively in a limited field of use drawn to development of antisense molecules in therapeutic protocols. Independent of such exclusive consideration, the same intellectual property rights could be licensed non-exclusively for diagnostic testing or as a research probe to study gene expression under varying physiological conditions.License agreements should be written with developmental milestones and benchmarks to ensure that the technology is fully developed by the licensee. The timely completion of milestones and benchmarks should be monitored and enforced. Best practices provide for modification or termination of licenses when progress toward commercialization is inadequate. Negotiated sublicensing terms and provisions optimally permit fair and appropriate participation of additional parties in the technology development process.Funding recipients and the intramural technology transfer community may find these recommendations helpful in achieving the universal goal of ensuring that public health consequences are considered when negotiating licenses for genomic technologies.PHS encourages licensing policies and strategies that maximize access, as well as commercial and research utilization of the technology to benefit the public health. For this reason, PHS believes that it is important for funding recipients and the intramural technology transfer community to reserve in their license agreements the right to use the licensed technologies for their own research and educational uses, and to allow other institutions to do the same, consistent with the Research Tools Guidelines.ConclusionPHS recognizes that these recommendations generally reflect practices that may already be followed by most funding recipients and the intramural technology transfer community with regard to licensing of genomic and other technologies. PHS also acknowledges the need for flexibility in the licensing negotiation process as the requirements of individual license negotiations may vary and may not always be adaptable to these best practices.Dated: April 5, 2005.Mark L. Rohrbaugh,Director, Office of Technology Transfer,National Institutes of Health. APPENDIX V - OECD, GUIDELINES FOR THE LICENSING OF GENETIC INVENTIONS (2006)The full report, including Background, Preface and PART II: Annotations, is available at: http://www.oecd.org/dataoecd/39/38/36198812.pdfPART I: PRINCIPLES AND BEST PRACTICES FOR THE LICENSING OF GENETIC INVENTIONS A. Scope These Guidelines apply to the licensing of intellectual property rights that relate to genetic inventions used for the purpose of human healthcare. Within these Guidelines, the term “Genetic Invention” includes nucleic acids, nucleotide sequences and their expression products; transformed cell lines; vectors; as well as methods, technologies and materials for making, using or analysing such nucleic acids, nucleotide sequences, cell lines or vectors. This definition is intended to be forward looking to encompass highly related future developments. B. Principles and Best Practices 1. Licensing Generally Principles 1. A Licensing practices should foster innovation in the development of new genetic inventions related to human healthcare and should ensure that therapeutics, diagnostics and other products and services employing genetic inventions are made readily available on a reasonable basis. 1. B Licensing practices should encourage the rapid dissemination of information concerning genetic inventions. 1. C Licensing practices should provide an opportunity for licensors and licensees to obtain returns from their investment with respect to genetic inventions. 1. D Licensees and licensors should have reasonable certainty over their rights and the limitations to those rights in relation to genetic inventions.Best Practices 1.1 License agreements should permit licensees to develop and further improve the licensed genetic inventions. 1.2 License agreements should clearly set out which parties obtain, retain, receive and maintain ownership of, grant rights to and enforce intellectual property rights, including with respect to the improvements and new genetic inventions developed from the licensed technology. 1.3 Licence agreements should clearly set out which of the parties, if any, has the right to engage in collaborative research with third parties and set out the ownership of any intellectual property rights flowing from such collaborative research. 1.4 Confidentiality provisions should be carefully drafted so as to permit the dissemination of information pertaining to genetic inventions while taking into account the need to file patent applications, to protect undisclosed information and to capitalise on the inventions in the marketplace. 1.5 License agreements should not provide the licensor with exclusive control over human genetic information, including collections of such information, derived from individuals through the use of the licensed genetic invention. 1.6 Rights holders should be encouraged to agree to licensing terms and conditions that maximize the utilisation of their genetic inventions. 1.7 License agreements should clearly stipulate the duties, obligations and responsibilities of the parties and address the rights of the parties to use the improvements to the licensed genetic invention following any, including early, termination. 1.8 License agreements should define the roles and responsibilities of the parties in the commercialisation, if any, of the products and services arising from the use of the licensed genetic invention.2. Healthcare and Genetic Inventions Principles 2. A Licensing practices should seek to strike a balance between the delivery of new products and services, healthcare needs, and economic returns. 2. B Licensing practices should ensure that patients benefit from the highest applicable standards with respect to privacy, safety and good laboratory methods available pursuant to the laws of their jurisdiction or those of the jurisdiction of the service provider using the genetic invention. 2. C Licensing practices should not be used to restrict the choice of other products or services by patients and their healthcare providers. 2. D Licensing practices should encourage appropriate access to and use of genetic inventions to address unmet and urgent health needs in OECD member countries and non-member economies. Best Practices 2.1 Rights holders should broadly license genetic inventions for research and investigation purposes. 2.2 Rights holders should license genetic inventions for health applications, including diagnostic testing, on terms and conditions that seek to ensure the widest public access to, and variety of, products and services based on the inventions. 2.3 Licensing practices should permit national or local providers to use genetic inventions in order to provide healthcare services, even if the rights holder is based in another jurisdiction. 2.4 Licensing agreements relating to products and services incorporating personal health information should facilitate compliance by the licensor and the licensee with the highest applicable privacy and other relevant laws. 2.5 License agreements should not restrict access by the licensee’s researchers to databases generated from licensed genetic inventions in their efforts to develop new therapies, products or services. 2.6 License agreements should permit licensees, for example healthcare providers, to offer patients flexibility and choice with respect to the selection of the type and nature of healthcare products and services.3. Research Freedom Principles 3. A Licensing practices should increase rather than decrease access to genetic inventions for research purposes. 3. B Commercial considerations in public research activities should not unduly hinder the academic freedom of researchers. 3. C Commercial considerations in public research activities and, in particular, the need to preserve the opportunity to seek patent protection on inventions arising from these activities, should not unduly limit the ability to publish in a timely manner the results of research. 3. D Commercial considerations in public research activities should not unduly limit the educational training of students. Best Practices 3.1 License agreements should clearly delineate research areas, information and time frames in which researchers and students cannot publish or present papers or theses without violating confidentiality obligations. Licensors and licensees should inform all relevant individuals, including students, of the scope of confidentiality obligations in a timely fashion. 3.2 Licensors and licensees should educate their researchers with respect to intellectual property law, especially the effects of public disclosure on the patentability of inventions, confidentiality obligations and restrictions commonly contained in agreements. 3.3 Confidentiality provisions should provide that academic research arising pursuant to the license agreement can be freely published or disclosed, with as minimum a delay as possible, subject to the need to protect proprietary information disclosed to the licensee or arising from such research. 3.4 Delays in publications of academic research necessary, for example, for the filing of patent applications, should be limited and reasonable in the circumstances. 3.5 Confidentiality provisions in licensing agreements should be drafted as narrowly as suitable and should not prevent the possibility of reasonable disclosure in exceptional public health situations, in light of the objectives of the parties and the applicable law.4. Commercial Development Principles 4. A Foundational genetic inventions should be licensed so as to be broadly accessible. 4. B Licensing practices should be used as an effective means to create value for licensors and licensees through the development of new products and services from genetic inventions. 4. C Licensing practices should strive to overcome co-ordination problems resulting from the need to access multiple genetic inventions. Best Practices 4.1 Should several licenses be required, license agreements should include a mechanism to set a reasonable overall royalty burden for genetic invention products and services, including research tools. 4.2 License agreements should include terms that maintain low barriers for access to genetic inventions. This may mean that such agreements do not include, for example, excessive up-front fees. 4.3 License agreements should avoid reach-through rights so as to foster broad and unencumbered utilisation of the genetic invention and so as to not discourage or stifle subsequent innovations. 4.4 Private and public sector participants should develop mechanisms to decrease transaction costs in acquiring rights to use technology. 4.5 Organisations that may enter into license agreements should educate their decision-makers about the opportunities to use the least restrictive licensing practices, as appropriate, as a means to maximise the benefits from genetic inventions for society, shareholders and other stakeholders.5. Competition Principles 5. A Licensing practices pertaining to genetic inventions should foster economic growth through innovation and substantive competition, while complying with the applicable competition laws. 5. B Licensing practices should not be used to expand the breadth of exclusive rights beyond the scope of the relevant intellectual property rights. Best Practices 5.1 License agreements should avoid unduly restrictive tied-selling. 5.2 License agreements should avoid non-compete clauses in areas beyond the scope of licensed genetic invention. 5.3 License agreements relating to foundational genetic inventions should generally be non-exclusive to encourage broad access for researchers and patients and broad use of the genetic invention.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001000775 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00001051378 cram 9.7 GB
EGAF00001051379 cram 10.2 GB
EGAF00001051380 cram 9.9 GB
EGAF00001051381 cram 7.3 GB
EGAF00001051382 cram 12.6 GB
EGAF00001051383 cram 10.6 GB
EGAF00001051384 cram 11.5 GB
EGAF00001051385 cram 16.3 GB
EGAF00001051386 cram 11.1 GB
EGAF00001051387 cram 11.1 GB
EGAF00001051388 cram 9.2 GB
EGAF00001051389 cram 14.9 GB
EGAF00001051390 cram 11.3 GB
EGAF00001051391 cram 8.9 GB
EGAF00001051392 cram 7.7 GB
EGAF00001051393 cram 10.2 GB
EGAF00001051394 cram 8.8 GB
EGAF00001051395 cram 7.3 GB
EGAF00001051396 cram 6.6 GB
EGAF00001051397 cram 9.6 GB
EGAF00001051398 cram 7.7 GB
EGAF00001051399 cram 7.8 GB
EGAF00001051400 cram 9.6 GB
EGAF00001051401 cram 8.1 GB
EGAF00001051402 cram 9.1 GB
EGAF00001051403 cram 8.9 GB
EGAF00001051404 cram 10.4 GB
EGAF00001051405 cram 6.9 GB
EGAF00001051406 cram 12.9 GB
EGAF00001051407 cram 10.9 GB
EGAF00001051408 cram 8.9 GB
EGAF00001051409 cram 8.4 GB
EGAF00001051410 cram 7.8 GB
EGAF00001051411 cram 14.5 GB
EGAF00001051412 cram 5.3 GB
EGAF00001051413 cram 8.2 GB
EGAF00001051414 cram 7.6 GB
EGAF00001051415 cram 7.1 GB
EGAF00001051416 cram 6.8 GB
EGAF00001051417 cram 15.2 GB
EGAF00001051418 cram 8.8 GB
EGAF00001051419 cram 7.2 GB
EGAF00001051420 cram 7.5 GB
EGAF00001051421 cram 6.4 GB
EGAF00001051422 cram 7.8 GB
EGAF00001051423 cram 9.6 GB
EGAF00001051424 cram 7.9 GB
EGAF00001051425 cram 8.2 GB
EGAF00001051426 cram 7.9 GB
EGAF00001051427 cram 9.0 GB
EGAF00001051428 cram 8.6 GB
EGAF00001051429 cram 8.6 GB
EGAF00001051430 cram 8.6 GB
EGAF00001051431 cram 9.5 GB
EGAF00001051432 cram 8.8 GB
EGAF00001051433 cram 7.1 GB
EGAF00001051434 cram 8.6 GB
EGAF00001051435 cram 6.8 GB
EGAF00001051436 cram 8.5 GB
EGAF00001051437 cram 8.1 GB
EGAF00001051438 cram 9.1 GB
EGAF00001051439 cram 9.9 GB
EGAF00001051440 cram 8.7 GB
EGAF00001051441 cram 13.1 GB
EGAF00001051442 cram 9.3 GB
EGAF00001051443 cram 14.1 GB
EGAF00001051444 cram 7.7 GB
EGAF00001051445 cram 8.1 GB
EGAF00001051446 cram 8.9 GB
EGAF00001051447 cram 7.4 GB
EGAF00001051448 cram 9.9 GB
EGAF00001051449 cram 8.6 GB
EGAF00001051450 cram 7.2 GB
EGAF00001051451 cram 7.5 GB
EGAF00001051452 cram 9.9 GB
EGAF00001051453 cram 8.3 GB
EGAF00001051454 cram 8.6 GB
EGAF00001051455 cram 8.5 GB
EGAF00001051456 cram 8.2 GB
EGAF00001051457 cram 7.2 GB
EGAF00001051458 cram 4.9 GB
EGAF00001051459 cram 9.1 GB
EGAF00001051460 cram 8.1 GB
EGAF00001051461 cram 9.3 GB
EGAF00001051462 cram 8.7 GB
EGAF00001051463 cram 8.7 GB
EGAF00001051464 cram 13.6 GB
EGAF00001051465 cram 11.4 GB
EGAF00001051466 cram 7.8 GB
EGAF00001051467 cram 7.0 GB
EGAF00001051468 cram 8.5 GB
EGAF00001051469 cram 13.5 GB
EGAF00001051470 cram 7.7 GB
EGAF00001051471 cram 10.2 GB
EGAF00001051472 cram 8.3 GB
EGAF00001051473 cram 13.5 GB
EGAF00001051474 cram 8.2 GB
EGAF00001051475 cram 8.4 GB
EGAF00001051476 cram 10.7 GB
EGAF00001051477 cram 15.0 GB
EGAF00001051478 cram 8.7 GB
EGAF00001051479 cram 15.6 GB
EGAF00001051480 cram 8.0 GB
EGAF00001051481 cram 17.0 GB
EGAF00001051482 cram 8.5 GB
EGAF00001051483 cram 11.3 GB
EGAF00001051484 cram 7.7 GB
EGAF00001051485 cram 3.5 GB
EGAF00001051486 cram 8.5 GB
EGAF00001051487 cram 7.5 GB
EGAF00001051488 cram 7.3 GB
EGAF00001051489 cram 7.8 GB
EGAF00001051490 cram 9.3 GB
EGAF00001051491 cram 8.2 GB
EGAF00001051492 cram 6.6 GB
EGAF00001051493 cram 7.4 GB
EGAF00001051494 cram 5.5 GB
EGAF00001051495 cram 18.6 GB
EGAF00001051496 cram 8.2 GB
EGAF00001051497 cram 8.0 GB
EGAF00001051498 cram 8.8 GB
EGAF00001051499 cram 9.6 GB
EGAF00001051500 cram 7.0 GB
EGAF00001051501 cram 8.4 GB
EGAF00001051502 cram 7.5 GB
EGAF00001051503 cram 6.8 GB
EGAF00001051504 cram 8.8 GB
EGAF00001051505 cram 6.9 GB
EGAF00001051506 cram 8.6 GB
EGAF00001051507 cram 7.2 GB
EGAF00001051508 cram 6.4 GB
EGAF00001051509 cram 7.7 GB
EGAF00001051510 cram 10.8 GB
EGAF00001051511 cram 9.1 GB
EGAF00001051512 cram 7.6 GB
EGAF00001051513 cram 6.7 GB
EGAF00001051514 cram 9.1 GB
EGAF00001051515 cram 4.8 GB
EGAF00001051516 cram 7.9 GB
EGAF00001051517 cram 4.7 GB
EGAF00001051518 cram 9.9 GB
EGAF00001051519 cram 8.1 GB
EGAF00001051520 cram 7.8 GB
EGAF00001051521 cram 8.8 GB
EGAF00001051522 cram 8.7 GB
EGAF00001051523 cram 7.4 GB
EGAF00001051524 cram 7.9 GB
EGAF00001051525 cram 10.7 GB
EGAF00001051526 cram 8.2 GB
EGAF00001051527 cram 10.1 GB
EGAF00001051528 cram 7.6 GB
EGAF00001051529 cram 9.0 GB
EGAF00001051530 cram 9.3 GB
EGAF00001051531 cram 8.1 GB
EGAF00001051532 cram 10.0 GB
EGAF00001051533 cram 8.5 GB
EGAF00001051534 cram 7.5 GB
EGAF00001051535 cram 7.3 GB
EGAF00001051536 cram 7.4 GB
EGAF00001051537 cram 7.5 GB
EGAF00001051538 cram 8.0 GB
EGAF00001051539 cram 8.5 GB
EGAF00001051540 cram 9.4 GB
EGAF00001051541 cram 7.5 GB
EGAF00001051542 cram 9.4 GB
EGAF00001051543 cram 5.9 GB
EGAF00001051544 cram 8.8 GB
EGAF00001051545 cram 8.4 GB
EGAF00001051546 cram 6.8 GB
EGAF00001051547 cram 6.7 GB
EGAF00001051548 cram 6.1 GB
EGAF00001051549 cram 8.0 GB
EGAF00001051550 cram 12.2 GB
EGAF00001051551 cram 9.6 GB
EGAF00001051552 cram 12.4 GB
EGAF00001051553 cram 9.0 GB
EGAF00001051554 cram 8.4 GB
EGAF00001051555 cram 8.5 GB
EGAF00001051556 cram 8.6 GB
EGAF00001051557 cram 13.5 GB
EGAF00001051558 cram 8.5 GB
EGAF00001051559 cram 6.8 GB
EGAF00001051560 cram 9.0 GB
EGAF00001051561 cram 7.8 GB
EGAF00001051562 cram 14.4 GB
EGAF00001051563 cram 8.6 GB
EGAF00001051564 cram 6.9 GB
EGAF00001051565 cram 7.6 GB
EGAF00001051566 cram 8.1 GB
EGAF00001051567 cram 7.6 GB
EGAF00001051568 cram 8.8 GB
EGAF00001051569 cram 5.9 GB
EGAF00001051570 cram 7.3 GB
EGAF00001051571 cram 7.1 GB
EGAF00001051572 cram 9.8 GB
EGAF00001051573 cram 7.6 GB
EGAF00001051574 cram 7.8 GB
EGAF00001051575 cram 8.4 GB
EGAF00001051576 cram 8.9 GB
EGAF00001051577 cram 7.8 GB
EGAF00001051578 cram 7.2 GB
EGAF00001051579 cram 7.7 GB
EGAF00001051580 cram 11.8 GB
EGAF00001051581 cram 7.9 GB
EGAF00001051582 cram 10.7 GB
EGAF00001051583 cram 7.5 GB
EGAF00001051584 cram 8.9 GB
EGAF00001051585 cram 8.5 GB
EGAF00001051586 cram 8.9 GB
EGAF00001051587 cram 7.2 GB
EGAF00001051588 cram 12.9 GB
EGAF00001051589 cram 8.0 GB
EGAF00001051590 cram 9.1 GB
EGAF00001051591 cram 8.0 GB
EGAF00001051592 cram 6.5 GB
EGAF00001051594 cram 13.4 GB
EGAF00001051595 cram 10.4 GB
EGAF00001051596 cram 6.3 GB
EGAF00001051597 cram 11.0 GB
EGAF00001051598 cram 10.3 GB
EGAF00001051599 cram 9.7 GB
EGAF00001051600 cram 9.4 GB
EGAF00001051601 cram 7.8 GB
EGAF00001051602 cram 7.4 GB
EGAF00001051603 cram 9.6 GB
EGAF00001051604 cram 8.6 GB
EGAF00001051605 cram 8.8 GB
EGAF00001051606 cram 8.2 GB
EGAF00001051607 cram 10.1 GB
EGAF00001051608 cram 8.1 GB
EGAF00001051609 cram 6.7 GB
EGAF00001051610 cram 7.9 GB
EGAF00001051611 cram 5.7 GB
EGAF00001051612 cram 14.5 GB
EGAF00001051613 cram 9.6 GB
EGAF00001051614 cram 12.6 GB
EGAF00001051615 cram 13.7 GB
EGAF00001051616 cram 8.7 GB
EGAF00001051617 cram 10.5 GB
EGAF00001051618 cram 8.3 GB
EGAF00001051619 cram 6.9 GB
EGAF00001051620 cram 7.9 GB
EGAF00001051621 cram 13.5 GB
EGAF00001051622 cram 7.8 GB
EGAF00001051623 cram 11.6 GB
EGAF00001051624 cram 7.9 GB
EGAF00001051625 cram 7.6 GB
EGAF00001051626 cram 8.4 GB
EGAF00001051627 cram 8.5 GB
EGAF00001051628 cram 8.2 GB
EGAF00001051629 cram 7.6 GB
EGAF00001051630 cram 9.1 GB
EGAF00001051631 cram 9.3 GB
EGAF00001051632 cram 8.5 GB
EGAF00001051633 cram 8.7 GB
EGAF00001051634 cram 7.9 GB
EGAF00001051635 cram 8.2 GB
EGAF00001051636 cram 7.5 GB
EGAF00001051637 cram 6.9 GB
EGAF00001051638 cram 7.8 GB
EGAF00001051639 cram 7.3 GB
EGAF00001051640 cram 9.9 GB
EGAF00001051641 cram 10.4 GB
EGAF00001051642 cram 7.4 GB
EGAF00001051643 cram 7.5 GB
EGAF00001051644 cram 8.2 GB
EGAF00001051645 cram 8.3 GB
EGAF00001051646 cram 6.8 GB
EGAF00001051647 cram 9.4 GB
EGAF00001051648 cram 7.3 GB
EGAF00001051649 cram 9.6 GB
EGAF00001051650 cram 7.9 GB
EGAF00001051651 cram 8.8 GB
EGAF00001051652 cram 9.1 GB
EGAF00001051653 cram 12.6 GB
EGAF00001051654 cram 6.6 GB
EGAF00001051655 cram 8.9 GB
EGAF00001051656 cram 8.3 GB
EGAF00001051657 cram 8.7 GB
EGAF00001051658 cram 13.9 GB
EGAF00001051659 cram 8.4 GB
EGAF00001051660 cram 8.2 GB
EGAF00001051661 cram 8.2 GB
EGAF00001051662 cram 8.5 GB
EGAF00001051663 cram 7.3 GB
EGAF00001051664 cram 8.3 GB
EGAF00001051665 cram 11.0 GB
EGAF00001051666 cram 7.1 GB
EGAF00001051667 cram 8.5 GB
EGAF00001051668 cram 7.7 GB
EGAF00001051669 cram 12.8 GB
EGAF00001051670 cram 11.6 GB
EGAF00001051671 cram 9.1 GB
EGAF00001051672 cram 15.6 GB
EGAF00001051673 cram 10.1 GB
EGAF00001051674 cram 7.8 GB
EGAF00001051675 cram 7.8 GB
EGAF00001051676 cram 9.5 GB
EGAF00001051677 cram 11.4 GB
EGAF00001051678 cram 14.3 GB
EGAF00001051679 cram 12.3 GB
EGAF00001051680 cram 8.7 GB
EGAF00001051681 cram 8.1 GB
EGAF00001051682 cram 8.4 GB
EGAF00001051683 cram 30.0 GB
EGAF00001051684 cram 7.8 GB
EGAF00001051685 cram 5.5 GB
EGAF00001051687 cram 9.6 GB
EGAF00001051688 cram 7.8 GB
EGAF00001051689 cram 9.3 GB
EGAF00001051690 cram 9.2 GB
EGAF00001051691 cram 7.6 GB
EGAF00001051692 cram 8.0 GB
EGAF00001051693 cram 9.1 GB
EGAF00001051694 cram 9.3 GB
EGAF00001051695 cram 7.1 GB
EGAF00001051696 cram 7.6 GB
EGAF00001051697 cram 8.6 GB
EGAF00001051698 cram 8.4 GB
EGAF00001051699 cram 8.8 GB
EGAF00001051700 cram 8.2 GB
EGAF00001051701 cram 8.4 GB
EGAF00001051702 cram 6.8 GB
EGAF00001051703 cram 7.4 GB
EGAF00001051704 cram 8.3 GB
EGAF00001051705 cram 8.2 GB
EGAF00001051706 cram 8.3 GB
EGAF00001051707 cram 8.0 GB
EGAF00001051708 cram 7.2 GB
EGAF00001051709 cram 7.8 GB
EGAF00001051710 cram 7.3 GB
EGAF00001051711 cram 8.1 GB
EGAF00001051712 cram 8.9 GB
EGAF00001051713 cram 7.4 GB
EGAF00001051714 cram 9.7 GB
EGAF00001051715 cram 7.6 GB
EGAF00001051716 cram 6.3 GB
EGAF00001051717 cram 8.3 GB
EGAF00001051718 cram 9.0 GB
EGAF00001051719 cram 9.6 GB
EGAF00001051720 cram 15.4 GB
EGAF00001051721 cram 5.5 GB
EGAF00001051722 cram 12.3 GB
EGAF00001051723 cram 8.0 GB
EGAF00001051724 cram 9.5 GB
EGAF00001051725 cram 8.4 GB
EGAF00001051726 cram 9.1 GB
EGAF00001051727 cram 7.1 GB
EGAF00001051728 cram 14.8 GB
EGAF00001051729 cram 12.0 GB
EGAF00001051730 cram 8.9 GB
EGAF00001051731 cram 8.8 GB
EGAF00001051732 cram 8.2 GB
EGAF00001051733 cram 11.8 GB
EGAF00001051734 cram 12.2 GB
EGAF00001051735 cram 12.4 GB
EGAF00001051736 cram 7.9 GB
EGAF00001051737 cram 8.0 GB
EGAF00001051738 cram 14.7 GB
EGAF00001051739 cram 13.1 GB
EGAF00001051740 cram 6.3 GB
EGAF00001051741 cram 10.5 GB
EGAF00001051742 cram 10.6 GB
EGAF00001051743 cram 9.9 GB
EGAF00001051744 cram 10.5 GB
EGAF00001051745 cram 7.6 GB
EGAF00001051746 cram 9.9 GB
EGAF00001051747 cram 8.1 GB
EGAF00001051748 cram 10.3 GB
EGAF00001051749 cram 9.4 GB
EGAF00001051750 cram 9.0 GB
EGAF00001051751 cram 6.8 GB
EGAF00001051752 cram 8.4 GB
EGAF00001051753 cram 9.2 GB
EGAF00001051754 cram 9.0 GB
EGAF00001051755 cram 5.1 GB
EGAF00001051756 cram 8.9 GB
EGAF00001051757 cram 10.0 GB
EGAF00001051758 cram 7.9 GB
EGAF00001051759 cram 5.3 GB
EGAF00001051760 cram 8.8 GB
EGAF00001051761 cram 8.6 GB
EGAF00001051762 cram 8.4 GB
EGAF00001051763 cram 8.0 GB
EGAF00001051764 cram 8.4 GB
EGAF00001051765 cram 9.6 GB
EGAF00001051766 cram 8.2 GB
EGAF00001051767 cram 8.2 GB
EGAF00001051768 cram 8.7 GB
EGAF00001051769 cram 8.2 GB
EGAF00001051770 cram 9.3 GB
EGAF00001051771 cram 13.5 GB
EGAF00001051772 cram 12.1 GB
EGAF00001051773 cram 8.8 GB
EGAF00001051774 cram 9.2 GB
EGAF00001051775 cram 9.1 GB
EGAF00001051776 cram 8.9 GB
EGAF00001051777 cram 7.8 GB
EGAF00001051778 cram 14.2 GB
EGAF00001051779 cram 8.4 GB
EGAF00001051780 cram 6.7 GB
EGAF00001051781 cram 8.9 GB
EGAF00001051782 cram 12.2 GB
EGAF00001051783 cram 9.0 GB
EGAF00001051784 cram 6.7 GB
EGAF00001051785 cram 7.5 GB
EGAF00001051786 cram 8.3 GB
EGAF00001051787 cram 7.3 GB
EGAF00001051788 cram 7.3 GB
EGAF00001051789 cram 8.4 GB
EGAF00001051790 cram 9.6 GB
EGAF00001051791 cram 8.7 GB
EGAF00001051792 cram 8.4 GB
EGAF00001051793 cram 6.2 GB
EGAF00001051794 cram 8.3 GB
EGAF00001051795 cram 8.3 GB
EGAF00001051796 cram 7.8 GB
EGAF00001051797 cram 7.7 GB
EGAF00001051798 cram 9.2 GB
EGAF00001051799 cram 8.8 GB
EGAF00001051800 cram 9.6 GB
EGAF00001051801 cram 8.1 GB
EGAF00001051802 cram 6.5 GB
EGAF00001051803 cram 7.8 GB
EGAF00001051804 cram 8.2 GB
EGAF00001051805 cram 7.2 GB
EGAF00001051806 cram 6.0 GB
EGAF00001051807 cram 11.6 GB
EGAF00001051808 cram 9.7 GB
EGAF00001051809 cram 6.8 GB
EGAF00001051810 cram 7.2 GB
EGAF00001051811 cram 6.7 GB
EGAF00001051812 cram 10.0 GB
EGAF00001051813 cram 7.7 GB
EGAF00001051814 cram 7.7 GB
EGAF00001051815 cram 11.8 GB
EGAF00001051816 cram 10.4 GB
EGAF00001051817 cram 8.9 GB
EGAF00001051818 cram 9.8 GB
EGAF00001051819 cram 11.3 GB
EGAF00001051820 cram 12.4 GB
EGAF00001051821 cram 12.1 GB
EGAF00001051822 cram 7.4 GB
EGAF00001051823 cram 7.2 GB
EGAF00001051824 cram 9.7 GB
EGAF00001051825 cram 7.7 GB
EGAF00001051826 cram 7.4 GB
EGAF00001051827 cram 9.4 GB
EGAF00001051828 cram 7.3 GB
EGAF00001051829 cram 8.5 GB
EGAF00001051830 cram 7.6 GB
EGAF00001051831 cram 9.5 GB
EGAF00001051832 cram 7.0 GB
EGAF00001051833 cram 8.9 GB
EGAF00001051834 cram 8.3 GB
EGAF00001051835 cram 9.1 GB
EGAF00001051836 cram 6.6 GB
EGAF00001051837 cram 5.4 GB
EGAF00001051838 cram 10.9 GB
EGAF00001051839 cram 9.7 GB
EGAF00001051840 cram 8.3 GB
EGAF00001051841 cram 8.1 GB
EGAF00001051842 cram 7.6 GB
EGAF00001051843 cram 8.8 GB
EGAF00001051844 cram 7.4 GB
EGAF00001051845 cram 10.3 GB
EGAF00001051846 cram 10.9 GB
EGAF00001051847 cram 7.0 GB
EGAF00001051848 cram 7.7 GB
EGAF00001051849 cram 14.4 GB
EGAF00001051850 cram 9.6 GB
EGAF00001051851 cram 9.5 GB
EGAF00001051852 cram 8.3 GB
EGAF00001051853 cram 9.3 GB
EGAF00001051854 cram 7.8 GB
EGAF00001051855 cram 7.7 GB
EGAF00001051856 cram 8.7 GB
EGAF00001051857 cram 7.7 GB
EGAF00001051858 cram 8.8 GB
EGAF00001051859 cram 7.4 GB
EGAF00001051860 cram 8.8 GB
EGAF00001051861 cram 13.1 GB
EGAF00001051862 cram 8.1 GB
EGAF00001051863 cram 9.3 GB
EGAF00001051864 cram 8.7 GB
EGAF00001051865 cram 10.0 GB
EGAF00001051866 cram 10.4 GB
EGAF00001051867 cram 7.4 GB
EGAF00001051868 cram 9.1 GB
EGAF00001051869 cram 10.0 GB
EGAF00001051870 cram 8.7 GB
EGAF00001051871 cram 6.3 GB
EGAF00001051872 cram 8.9 GB
EGAF00001051873 cram 18.9 GB
EGAF00001051874 cram 8.9 GB
EGAF00001051875 cram 9.6 GB
EGAF00001051876 cram 9.2 GB
EGAF00001051877 cram 8.7 GB
EGAF00001051878 cram 7.8 GB
EGAF00001051879 cram 11.2 GB
EGAF00001051880 cram 6.9 GB
EGAF00001051881 cram 8.2 GB
EGAF00001051882 cram 8.6 GB
EGAF00001051883 cram 10.3 GB
EGAF00001051884 cram 6.9 GB
EGAF00001051885 cram 17.7 GB
EGAF00001051886 cram 10.7 GB
EGAF00001051887 cram 9.3 GB
EGAF00001051888 cram 9.5 GB
EGAF00001051889 cram 8.0 GB
EGAF00001051890 cram 8.9 GB
EGAF00001051891 cram 8.0 GB
EGAF00001051892 cram 11.9 GB
EGAF00001051893 cram 9.8 GB
EGAF00001051894 cram 13.2 GB
EGAF00001051895 cram 7.9 GB
EGAF00001051896 cram 7.2 GB
EGAF00001051897 cram 6.7 GB
EGAF00001051898 cram 9.9 GB
EGAF00001051899 cram 9.1 GB
EGAF00001051900 cram 7.7 GB
EGAF00001051901 cram 7.4 GB
EGAF00001051902 cram 8.1 GB
EGAF00001051903 cram 9.0 GB
EGAF00001051904 cram 9.1 GB
EGAF00001051905 cram 9.2 GB
EGAF00001051906 cram 8.7 GB
EGAF00001051907 cram 8.7 GB
EGAF00001051908 cram 7.9 GB
EGAF00001051909 cram 8.9 GB
EGAF00001051910 cram 7.3 GB
EGAF00001051911 cram 8.4 GB
EGAF00001051912 cram 8.8 GB
EGAF00001051913 cram 7.7 GB
EGAF00001051914 cram 10.0 GB
EGAF00001051915 cram 8.2 GB
EGAF00001051916 cram 12.9 GB
EGAF00001051917 cram 7.7 GB
EGAF00001051918 cram 8.9 GB
EGAF00001051919 cram 8.1 GB
EGAF00001051920 cram 8.2 GB
EGAF00001051921 cram 12.8 GB
EGAF00001051922 cram 8.1 GB
EGAF00001051923 cram 7.5 GB
EGAF00001051924 cram 8.4 GB
EGAF00001051925 cram 11.5 GB
EGAF00001051926 cram 7.8 GB
EGAF00001051927 cram 8.9 GB
EGAF00001051928 cram 9.4 GB
EGAF00001051929 cram 10.9 GB
EGAF00001051930 cram 9.0 GB
EGAF00001051931 cram 8.5 GB
EGAF00001051932 cram 7.2 GB
EGAF00001051933 cram 7.9 GB
EGAF00001051934 cram 7.1 GB
EGAF00001051935 cram 8.3 GB
EGAF00001051936 cram 8.6 GB
EGAF00001051937 cram 8.6 GB
EGAF00001051938 cram 6.9 GB
EGAF00001051939 cram 8.8 GB
EGAF00001051940 cram 6.5 GB
EGAF00001051941 cram 8.9 GB
EGAF00001051942 cram 8.1 GB
EGAF00001051943 cram 9.1 GB
EGAF00001051944 cram 8.0 GB
EGAF00001051945 cram 9.3 GB
EGAF00001051946 cram 8.2 GB
EGAF00001051947 cram 11.5 GB
EGAF00001051948 cram 9.9 GB
EGAF00001051949 cram 7.3 GB
EGAF00001051950 cram 8.0 GB
EGAF00001051951 cram 10.6 GB
EGAF00001051952 cram 8.3 GB
EGAF00001051953 cram 9.0 GB
EGAF00001051954 cram 8.2 GB
EGAF00001051955 cram 8.3 GB
EGAF00001051956 cram 9.3 GB
EGAF00001051957 cram 5.8 GB
EGAF00001051958 cram 8.5 GB
EGAF00001051959 cram 9.4 GB
EGAF00001051960 cram 8.0 GB
EGAF00001051961 cram 9.9 GB
EGAF00001051962 cram 8.0 GB
EGAF00001051963 cram 7.5 GB
EGAF00001051964 cram 7.2 GB
EGAF00001051965 cram 5.9 GB
EGAF00001051966 cram 11.8 GB
EGAF00001051967 cram 13.0 GB
EGAF00001051968 cram 8.7 GB
EGAF00001051969 cram 12.7 GB
EGAF00001051970 cram 11.2 GB
EGAF00001051971 cram 14.5 GB
EGAF00001051972 cram 10.5 GB
EGAF00001051973 cram 7.7 GB
EGAF00001051974 cram 9.6 GB
EGAF00001051975 cram 8.1 GB
EGAF00001051976 cram 7.6 GB
EGAF00001051977 cram 4.8 GB
EGAF00001051978 cram 6.7 GB
EGAF00001051979 cram 7.9 GB
EGAF00001051980 cram 9.5 GB
EGAF00001051981 cram 8.4 GB
EGAF00001051982 cram 9.7 GB
EGAF00001051983 cram 7.4 GB
EGAF00001051984 cram 7.8 GB
EGAF00001051985 cram 7.7 GB
EGAF00001051986 cram 8.6 GB
EGAF00001051987 cram 7.3 GB
EGAF00001051988 cram 10.8 GB
EGAF00001051989 cram 7.1 GB
EGAF00001051990 cram 7.4 GB
EGAF00001051991 cram 7.1 GB
EGAF00001051992 cram 7.4 GB
EGAF00001051993 cram 7.4 GB
EGAF00001051994 cram 7.3 GB
EGAF00001051995 cram 9.6 GB
EGAF00001051996 cram 8.3 GB
EGAF00001051997 cram 13.3 GB
EGAF00001051998 cram 8.7 GB
EGAF00001051999 cram 9.0 GB
EGAF00001052000 cram 9.0 GB
EGAF00001052001 cram 9.2 GB
EGAF00001052002 cram 5.1 GB
EGAF00001052003 cram 7.9 GB
EGAF00001052004 cram 11.2 GB
EGAF00001052005 cram 8.9 GB
EGAF00001052006 cram 8.1 GB
EGAF00001052007 cram 6.6 GB
EGAF00001052008 cram 9.2 GB
EGAF00001052009 cram 9.6 GB
EGAF00001052010 cram 8.5 GB
EGAF00001052011 cram 9.8 GB
EGAF00001052012 cram 8.9 GB
EGAF00001052013 cram 8.7 GB
EGAF00001052014 cram 9.2 GB
EGAF00001052015 cram 5.9 GB
EGAF00001052016 cram 7.5 GB
EGAF00001052017 cram 6.6 GB
EGAF00001052018 cram 5.8 GB
EGAF00001052019 cram 8.8 GB
EGAF00001052020 cram 8.7 GB
EGAF00001052021 cram 7.8 GB
EGAF00001052022 cram 8.3 GB
EGAF00001052023 cram 8.6 GB
EGAF00001052024 cram 8.7 GB
EGAF00001052025 cram 8.3 GB
EGAF00001052026 cram 10.0 GB
EGAF00001052027 cram 10.1 GB
EGAF00001052028 cram 8.8 GB
EGAF00001052029 cram 7.4 GB
EGAF00001052030 cram 21.3 GB
EGAF00001052031 cram 9.2 GB
EGAF00001052032 cram 11.3 GB
EGAF00001052033 cram 10.6 GB
EGAF00001052034 cram 8.8 GB
EGAF00001052035 cram 8.2 GB
EGAF00001052036 cram 19.1 GB
EGAF00001052037 cram 12.4 GB
EGAF00001052038 cram 10.1 GB
EGAF00001052039 cram 12.2 GB
EGAF00001052040 cram 8.8 GB
EGAF00001052041 cram 14.9 GB
EGAF00001052042 cram 8.3 GB
EGAF00001052043 cram 11.8 GB
EGAF00001052044 cram 6.7 GB
EGAF00001052045 cram 9.1 GB
EGAF00001052046 cram 8.4 GB
EGAF00001052047 cram 7.7 GB
EGAF00001052048 cram 9.3 GB
EGAF00001052049 cram 8.2 GB
EGAF00001052050 cram 7.8 GB
EGAF00001052051 cram 8.3 GB
EGAF00001052052 cram 7.2 GB
EGAF00001052053 cram 8.7 GB
EGAF00001052055 cram 7.7 GB
EGAF00001052056 cram 7.6 GB
EGAF00001052057 cram 5.4 GB
EGAF00001052058 cram 5.8 GB
EGAF00001052059 cram 8.1 GB
EGAF00001052060 cram 6.9 GB
EGAF00001052061 cram 7.4 GB
EGAF00001052062 cram 9.1 GB
EGAF00001052063 cram 6.1 GB
EGAF00001052064 cram 7.4 GB
EGAF00001052065 cram 6.4 GB
EGAF00001052066 cram 8.2 GB
EGAF00001052067 cram 9.6 GB
EGAF00001052068 cram 5.2 GB
EGAF00001052069 cram 8.3 GB
EGAF00001052070 cram 10.4 GB
EGAF00001052071 cram 7.7 GB
EGAF00001052072 cram 8.2 GB
EGAF00001052073 cram 8.4 GB
EGAF00001052074 cram 7.5 GB
EGAF00001052075 cram 9.5 GB
EGAF00001052076 cram 8.4 GB
EGAF00001052077 cram 7.7 GB
EGAF00001052078 cram 7.5 GB
EGAF00001052079 cram 7.2 GB
EGAF00001052080 cram 7.5 GB
EGAF00001052081 cram 6.6 GB
EGAF00001052082 cram 6.1 GB
EGAF00001052083 cram 10.2 GB
EGAF00001052084 cram 8.9 GB
EGAF00001052085 cram 6.5 GB
EGAF00001052086 cram 8.5 GB
EGAF00001052087 cram 10.4 GB
EGAF00001052088 cram 9.0 GB
EGAF00001052089 cram 12.6 GB
EGAF00001052090 cram 9.8 GB
EGAF00001052091 cram 9.4 GB
EGAF00001052092 cram 8.4 GB
EGAF00001052093 cram 12.5 GB
EGAF00001052094 cram 7.1 GB
EGAF00001052095 cram 6.7 GB
EGAF00001052096 cram 13.4 GB
EGAF00001052097 cram 8.2 GB
EGAF00001052098 cram 10.6 GB
EGAF00001052099 cram 13.6 GB
EGAF00001052100 cram 11.3 GB
EGAF00001052101 cram 11.9 GB
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EGAF00001052103 cram 14.3 GB
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EGAF00001052122 cram 7.9 GB
EGAF00001052123 cram 10.1 GB
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EGAF00001052126 cram 7.9 GB
EGAF00001052127 cram 14.0 GB
EGAF00001052128 cram 4.9 GB
EGAF00001052129 cram 14.5 GB
EGAF00001052130 cram 8.8 GB
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EGAF00001052137 cram 8.1 GB
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EGAF00001052140 cram 5.7 GB
EGAF00001052141 cram 9.0 GB
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EGAF00001052143 cram 6.7 GB
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EGAF00001052149 cram 8.2 GB
EGAF00001052150 cram 6.4 GB
EGAF00001052151 cram 12.7 GB
EGAF00001052152 cram 20.9 GB
EGAF00001052153 cram 8.9 GB
EGAF00001052154 cram 11.5 GB
EGAF00001052155 cram 12.2 GB
EGAF00001052156 cram 7.5 GB
EGAF00001052157 cram 14.2 GB
EGAF00001052158 cram 8.4 GB
EGAF00001052159 cram 9.8 GB
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EGAF00001052161 cram 8.8 GB
EGAF00001052162 cram 11.9 GB
EGAF00001052163 cram 7.7 GB
EGAF00001052164 cram 11.3 GB
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EGAF00001052167 cram 13.0 GB
EGAF00001052168 cram 7.8 GB
EGAF00001052169 cram 6.7 GB
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EGAF00001052173 cram 7.8 GB
EGAF00001052174 cram 8.7 GB
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EGAF00001052177 cram 8.8 GB
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EGAF00001052181 cram 6.9 GB
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EGAF00001052191 cram 7.6 GB
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EGAF00001052197 cram 10.0 GB
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EGAF00001052199 cram 9.6 GB
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EGAF00001052201 cram 11.0 GB
EGAF00001052202 cram 8.1 GB
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EGAF00001052204 cram 11.6 GB
EGAF00001052205 cram 9.1 GB
EGAF00001052206 cram 11.4 GB
EGAF00001052207 cram 11.0 GB
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EGAF00001052209 cram 11.6 GB
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EGAF00001052211 cram 7.7 GB
EGAF00001052212 cram 11.2 GB
EGAF00001052213 cram 6.8 GB
EGAF00001052214 cram 12.5 GB
EGAF00001052215 cram 7.0 GB
EGAF00001052216 cram 7.4 GB
EGAF00001052217 cram 11.3 GB
EGAF00001052218 cram 12.3 GB
EGAF00001052219 cram 10.5 GB
EGAF00001052220 cram 12.0 GB
EGAF00001052221 cram 8.8 GB
EGAF00001052222 cram 8.1 GB
EGAF00001052223 cram 12.5 GB
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EGAF00001052225 cram 7.5 GB
EGAF00001052226 cram 8.8 GB
EGAF00001052227 cram 6.2 GB
EGAF00001052228 cram 5.5 GB
EGAF00001052229 cram 7.7 GB
EGAF00001052230 cram 5.6 GB
EGAF00001052231 cram 8.6 GB
EGAF00001052232 cram 8.5 GB
EGAF00001052233 cram 8.7 GB
EGAF00001052234 cram 7.7 GB
EGAF00001052235 cram 7.8 GB
EGAF00001052236 cram 8.1 GB
EGAF00001052237 cram 6.4 GB
EGAF00001052238 cram 10.0 GB
EGAF00001052239 cram 10.1 GB
EGAF00001052240 cram 8.7 GB
EGAF00001052241 cram 15.0 GB
EGAF00001052242 cram 9.0 GB
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EGAF00001052244 cram 10.3 GB
EGAF00001052245 cram 8.5 GB
EGAF00001052246 cram 6.7 GB
EGAF00001052247 cram 9.3 GB
EGAF00001052248 cram 10.3 GB
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EGAF00001052250 cram 7.7 GB
EGAF00001052251 cram 7.2 GB
EGAF00001052252 cram 8.2 GB
EGAF00001052253 cram 7.8 GB
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EGAF00001052256 cram 8.0 GB
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EGAF00001052258 cram 8.8 GB
EGAF00001052259 cram 10.0 GB
EGAF00001052260 cram 8.0 GB
EGAF00001052261 cram 9.5 GB
EGAF00001052262 cram 5.7 GB
EGAF00001052263 cram 5.3 GB
EGAF00001052264 cram 8.3 GB
EGAF00001052265 cram 8.8 GB
EGAF00001052266 cram 9.5 GB
EGAF00001052267 cram 6.2 GB
EGAF00001052268 cram 7.2 GB
EGAF00001052269 cram 7.9 GB
EGAF00001052270 cram 12.8 GB
EGAF00001052271 cram 10.2 GB
EGAF00001052272 cram 7.5 GB
EGAF00001052273 cram 16.1 GB
EGAF00001052274 cram 12.2 GB
EGAF00001052275 cram 8.8 GB
EGAF00001052276 cram 7.1 GB
EGAF00001052277 cram 8.1 GB
EGAF00001052278 cram 6.3 GB
EGAF00001052279 cram 10.8 GB
EGAF00001052280 cram 8.9 GB
EGAF00001052281 cram 15.6 GB
EGAF00001052282 cram 8.9 GB
EGAF00001052283 cram 12.2 GB
EGAF00001052284 cram 10.7 GB
EGAF00001052285 cram 8.3 GB
EGAF00001052286 cram 8.4 GB
EGAF00001052287 cram 7.2 GB
EGAF00001052288 cram 7.8 GB
EGAF00001052289 cram 10.4 GB
EGAF00001052290 cram 9.9 GB
EGAF00001052291 cram 8.5 GB
EGAF00001052292 cram 7.9 GB
EGAF00001052293 cram 11.3 GB
EGAF00001052294 cram 10.3 GB
EGAF00001052295 cram 7.8 GB
EGAF00001052296 cram 8.1 GB
EGAF00001052297 cram 10.3 GB
EGAF00001052298 cram 10.0 GB
EGAF00001052299 cram 9.7 GB
EGAF00001052300 cram 8.1 GB
EGAF00001052301 cram 7.3 GB
EGAF00001052302 cram 8.6 GB
EGAF00001052303 cram 7.3 GB
EGAF00001052304 cram 9.0 GB
EGAF00001052305 cram 7.3 GB
EGAF00001052306 cram 7.1 GB
EGAF00001052307 cram 7.5 GB
EGAF00001052308 cram 10.6 GB
EGAF00001052309 cram 9.1 GB
EGAF00001052310 cram 10.1 GB
EGAF00001052311 cram 10.4 GB
EGAF00001052312 cram 7.7 GB
EGAF00001052313 cram 8.2 GB
EGAF00001052314 cram 8.5 GB
EGAF00001052315 cram 8.2 GB
EGAF00001052316 cram 11.4 GB
EGAF00001052317 cram 10.9 GB
EGAF00001052318 cram 9.0 GB
EGAF00001052319 cram 10.8 GB
EGAF00001052320 cram 8.0 GB
EGAF00001052321 cram 6.4 GB
EGAF00001052322 cram 8.5 GB
EGAF00001052323 cram 8.7 GB
EGAF00001052324 cram 7.8 GB
EGAF00001052325 cram 13.2 GB
EGAF00001052326 cram 6.3 GB
EGAF00001052327 cram 10.0 GB
EGAF00001052328 cram 10.4 GB
EGAF00001052329 cram 8.7 GB
EGAF00001052330 cram 8.9 GB
EGAF00001052331 cram 6.1 GB
EGAF00001052332 cram 9.7 GB
EGAF00001052333 cram 8.9 GB
EGAF00001052334 cram 7.6 GB
EGAF00001052335 cram 8.7 GB
EGAF00001052336 cram 15.6 GB
EGAF00001052337 cram 11.0 GB
EGAF00001052338 cram 12.7 GB
EGAF00001052339 cram 12.5 GB
EGAF00001052340 cram 10.4 GB
EGAF00001052341 cram 8.3 GB
EGAF00001052342 cram 8.1 GB
EGAF00001052343 cram 11.6 GB
EGAF00001052344 cram 8.1 GB
EGAF00001052345 cram 9.4 GB
EGAF00001052346 cram 8.3 GB
EGAF00001052347 cram 7.5 GB
EGAF00001052348 cram 8.1 GB
EGAF00001052349 cram 11.1 GB
EGAF00001052350 cram 7.5 GB
EGAF00001052351 cram 10.1 GB
EGAF00001052352 cram 8.0 GB
EGAF00001052353 cram 8.4 GB
EGAF00001052354 cram 7.8 GB
EGAF00001052355 cram 7.8 GB
EGAF00001052356 cram 8.5 GB
EGAF00001052357 cram 7.8 GB
EGAF00001052358 cram 8.3 GB
EGAF00001052359 cram 7.5 GB
EGAF00001052360 cram 8.3 GB
EGAF00001052361 cram 8.3 GB
EGAF00001052362 cram 7.3 GB
EGAF00001052363 cram 7.3 GB
EGAF00001052364 cram 8.4 GB
EGAF00001052365 cram 7.2 GB
EGAF00001052366 cram 10.4 GB
EGAF00001052367 cram 11.1 GB
EGAF00001052368 cram 13.8 GB
EGAF00001052369 cram 6.7 GB
EGAF00001052370 cram 6.9 GB
EGAF00001052372 cram 7.0 GB
EGAF00001052373 cram 7.6 GB
EGAF00001052374 cram 8.8 GB
EGAF00001052375 cram 10.9 GB
EGAF00001052376 cram 12.0 GB
EGAF00001052377 cram 9.3 GB
EGAF00001052378 cram 8.1 GB
EGAF00001052379 cram 10.4 GB
EGAF00001052380 cram 8.6 GB
EGAF00001052381 cram 8.7 GB
EGAF00001052382 cram 8.3 GB
EGAF00001052383 cram 6.5 GB
EGAF00001052384 cram 9.2 GB
EGAF00001052385 cram 11.6 GB
EGAF00001052386 cram 10.5 GB
EGAF00001052387 cram 7.4 GB
EGAF00001052388 cram 11.3 GB
EGAF00001052389 cram 8.7 GB
EGAF00001052390 cram 8.5 GB
EGAF00001052391 cram 10.2 GB
EGAF00001052392 cram 8.0 GB
EGAF00001052393 cram 8.6 GB
EGAF00001052394 cram 8.4 GB
EGAF00001052395 cram 9.3 GB
EGAF00001052396 cram 7.7 GB
EGAF00001052397 cram 8.2 GB
EGAF00001052398 cram 8.8 GB
EGAF00001052399 cram 9.6 GB
EGAF00001052400 cram 10.9 GB
EGAF00001052401 cram 10.9 GB
EGAF00001052402 cram 8.0 GB
EGAF00001052403 cram 12.6 GB
EGAF00001052404 cram 8.3 GB
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EGAF00001052406 cram 9.1 GB
EGAF00001052407 cram 8.7 GB
EGAF00001052408 cram 7.8 GB
EGAF00001052409 cram 7.1 GB
EGAF00001052410 cram 8.1 GB
EGAF00001052411 cram 8.5 GB
EGAF00001052412 cram 8.5 GB
EGAF00001052413 cram 8.8 GB
EGAF00001052414 cram 10.4 GB
EGAF00001052415 cram 14.9 GB
EGAF00001052416 cram 6.8 GB
EGAF00001052417 cram 8.5 GB
EGAF00001052418 cram 13.0 GB
EGAF00001052420 cram 8.1 GB
EGAF00001052421 cram 8.4 GB
EGAF00001052422 cram 8.1 GB
EGAF00001052423 cram 6.7 GB
EGAF00001052424 cram 7.8 GB
EGAF00001052425 cram 9.8 GB
EGAF00001052426 cram 8.0 GB
EGAF00001052427 cram 11.0 GB
EGAF00001052428 cram 13.0 GB
EGAF00001052429 cram 8.9 GB
EGAF00001052430 cram 9.7 GB
EGAF00001052431 cram 6.4 GB
EGAF00001052432 cram 9.3 GB
EGAF00001052433 cram 10.4 GB
EGAF00001052434 cram 7.6 GB
EGAF00001052435 cram 8.0 GB
EGAF00001052436 cram 9.4 GB
EGAF00001052437 cram 9.9 GB
EGAF00001052438 cram 8.7 GB
EGAF00001052439 cram 7.3 GB
EGAF00001052440 cram 8.5 GB
EGAF00001052441 cram 11.6 GB
EGAF00001052442 cram 7.9 GB
EGAF00001052443 cram 8.5 GB
EGAF00001052444 cram 14.8 GB
EGAF00001052445 cram 7.5 GB
EGAF00001052446 cram 7.5 GB
EGAF00001052447 cram 10.1 GB
EGAF00001052448 cram 6.5 GB
EGAF00001052449 cram 4.8 GB
EGAF00001052450 cram 11.5 GB
EGAF00001052451 cram 7.8 GB
EGAF00001052452 cram 6.2 GB
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EGAF00001052454 cram 8.6 GB
EGAF00001052455 cram 8.1 GB
EGAF00001052456 cram 8.3 GB
EGAF00001052457 cram 7.4 GB
EGAF00001052458 cram 9.4 GB
EGAF00001052459 cram 11.7 GB
EGAF00001052460 cram 5.9 GB
EGAF00001052461 cram 8.5 GB
EGAF00001052462 cram 7.3 GB
EGAF00001052463 cram 11.5 GB
EGAF00001052464 cram 11.1 GB
EGAF00001052465 cram 9.6 GB
EGAF00001052466 cram 11.8 GB
EGAF00001052467 cram 8.3 GB
EGAF00001052468 cram 9.1 GB
EGAF00001052469 cram 6.7 GB
EGAF00001052470 cram 9.0 GB
EGAF00001052471 cram 7.2 GB
EGAF00001052472 cram 11.7 GB
EGAF00001052473 cram 8.0 GB
EGAF00001052474 cram 6.2 GB
EGAF00001052475 cram 7.3 GB
EGAF00001052476 cram 8.0 GB
EGAF00001052477 cram 11.4 GB
EGAF00001052478 cram 13.9 GB
EGAF00001052479 cram 3.9 GB
EGAF00001052480 cram 8.7 GB
EGAF00001052481 cram 16.0 GB
EGAF00001052482 cram 12.7 GB
EGAF00001052483 cram 8.4 GB
EGAF00001052484 cram 7.5 GB
EGAF00001052485 cram 6.9 GB
EGAF00001052486 cram 8.3 GB
EGAF00001052487 cram 3.8 GB
EGAF00001052488 cram 8.4 GB
EGAF00001052489 cram 9.7 GB
EGAF00001052490 cram 10.5 GB
EGAF00001052491 cram 8.4 GB
EGAF00001052492 cram 9.3 GB
EGAF00001052493 cram 9.2 GB
EGAF00001052494 cram 6.3 GB
EGAF00001052495 cram 6.3 GB
EGAF00001052496 cram 11.2 GB
EGAF00001052497 cram 7.8 GB
EGAF00001052498 cram 11.5 GB
EGAF00001052499 cram 5.1 GB
EGAF00001052500 cram 12.8 GB
EGAF00001052501 cram 11.1 GB
EGAF00001052502 cram 6.8 GB
EGAF00001052503 cram 8.0 GB
EGAF00001052504 cram 10.1 GB
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EGAF00001052506 cram 8.6 GB
EGAF00001052507 cram 8.7 GB
EGAF00001052508 cram 8.1 GB
EGAF00001052509 cram 11.4 GB
EGAF00001052510 cram 8.9 GB
EGAF00001052511 cram 8.7 GB
EGAF00001052512 cram 6.8 GB
EGAF00001052513 cram 8.5 GB
EGAF00001052514 cram 8.6 GB
EGAF00001052515 cram 11.6 GB
EGAF00001052516 cram 7.9 GB
EGAF00001052517 cram 7.8 GB
EGAF00001052518 cram 9.1 GB
EGAF00001052519 cram 10.3 GB
EGAF00001052520 cram 6.7 GB
EGAF00001052521 cram 9.2 GB
EGAF00001052522 cram 10.4 GB
EGAF00001052523 cram 9.7 GB
EGAF00001052524 cram 12.8 GB
EGAF00001052525 cram 10.2 GB
EGAF00001052526 cram 9.0 GB
EGAF00001052527 cram 8.5 GB
EGAF00001052528 cram 8.7 GB
EGAF00001052529 cram 7.0 GB
EGAF00001052530 cram 8.5 GB
EGAF00001052531 cram 8.6 GB
EGAF00001052532 cram 7.6 GB
EGAF00001052533 cram 6.6 GB
EGAF00001052534 cram 8.2 GB
EGAF00001052535 cram 13.4 GB
EGAF00001052536 cram 7.8 GB
EGAF00001052537 cram 9.7 GB
EGAF00001052538 cram 8.5 GB
EGAF00001052539 cram 7.3 GB
EGAF00001052540 cram 8.7 GB
EGAF00001052541 cram 7.0 GB
EGAF00001052542 cram 9.4 GB
EGAF00001052543 cram 11.2 GB
EGAF00001052544 cram 8.0 GB
EGAF00001052545 cram 10.2 GB
EGAF00001052546 cram 12.3 GB
EGAF00001052547 cram 3.4 GB
EGAF00001052548 cram 12.6 GB
EGAF00001052549 cram 6.6 GB
EGAF00001052550 cram 14.0 GB
EGAF00001052551 cram 5.9 GB
EGAF00001052552 cram 6.4 GB
EGAF00001052553 cram 6.5 GB
EGAF00001052554 cram 14.7 GB
EGAF00001052555 cram 9.4 GB
EGAF00001052556 cram 6.3 GB
EGAF00001052557 cram 9.5 GB
EGAF00001052558 cram 5.7 GB
EGAF00001052559 cram 7.7 GB
EGAF00001052560 cram 9.4 GB
EGAF00001052561 cram 13.5 GB
EGAF00001052562 cram 8.4 GB
EGAF00001052563 cram 12.2 GB
EGAF00001052564 cram 9.1 GB
EGAF00001052565 cram 8.7 GB
EGAF00001052566 cram 7.5 GB
EGAF00001052567 cram 11.4 GB
EGAF00001052568 cram 9.2 GB
EGAF00001052569 cram 9.1 GB
EGAF00001052570 cram 6.8 GB
EGAF00001052571 cram 7.1 GB
EGAF00001052572 cram 9.8 GB
EGAF00001052573 cram 11.0 GB
EGAF00001052574 cram 7.5 GB
EGAF00001052575 cram 9.6 GB
EGAF00001052576 cram 8.4 GB
EGAF00001052577 cram 8.3 GB
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EGAF00001052579 cram 8.5 GB
EGAF00001052580 cram 7.6 GB
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EGAF00001052583 cram 7.2 GB
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EGAF00001052585 cram 7.7 GB
EGAF00001052586 cram 7.6 GB
EGAF00001052587 cram 8.0 GB
EGAF00001052588 cram 11.1 GB
EGAF00001052589 cram 6.4 GB
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EGAF00001052592 cram 6.9 GB
EGAF00001052593 cram 8.3 GB
EGAF00001052594 cram 16.0 GB
EGAF00001052595 cram 11.5 GB
EGAF00001052596 cram 8.5 GB
EGAF00001052597 cram 10.7 GB
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EGAF00001052599 cram 10.3 GB
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EGAF00001052602 cram 10.3 GB
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EGAF00001052605 cram 8.7 GB
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EGAF00001052616 cram 9.7 GB
EGAF00001052617 cram 10.8 GB
EGAF00001052618 cram 10.5 GB
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EGAF00001052620 cram 9.6 GB
EGAF00001052621 cram 14.3 GB
EGAF00001052622 cram 11.9 GB
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EGAF00001052626 cram 10.5 GB
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EGAF00001052628 cram 8.4 GB
EGAF00001052629 cram 10.1 GB
EGAF00001052630 cram 11.0 GB
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EGAF00001052633 cram 10.1 GB
EGAF00001052634 cram 8.6 GB
EGAF00001052635 cram 9.3 GB
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EGAF00001052639 cram 6.9 GB
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EGAF00001052654 cram 7.3 GB
EGAF00001052655 cram 16.9 GB
EGAF00001052656 cram 6.4 GB
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EGAF00001052666 cram 8.6 GB
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EGAF00001052679 cram 9.5 GB
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EGAF00001052681 cram 8.9 GB
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EGAF00001052683 cram 7.9 GB
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EGAF00001052687 cram 12.4 GB
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EGAF00001052692 cram 11.6 GB
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EGAF00001052704 cram 9.7 GB
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EGAF00001052708 cram 9.8 GB
EGAF00001052709 cram 9.1 GB
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EGAF00001052712 cram 10.3 GB
EGAF00001052713 cram 12.5 GB
EGAF00001052714 cram 11.0 GB
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EGAF00001052723 cram 9.3 GB
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EGAF00001052729 cram 13.4 GB
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EGAF00001052732 cram 15.0 GB
EGAF00001052733 cram 26.0 GB
EGAF00001052734 cram 11.8 GB
EGAF00001052735 cram 8.9 GB
EGAF00001052736 cram 9.8 GB
EGAF00001052737 cram 9.6 GB
EGAF00001052738 cram 12.3 GB
EGAF00001052739 cram 9.0 GB
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EGAF00001052750 cram 10.0 GB
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EGAF00001052756 cram 10.7 GB
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EGAF00001052765 cram 8.7 GB
EGAF00001052766 cram 9.7 GB
EGAF00001052767 cram 5.8 GB
EGAF00001052768 cram 7.6 GB
EGAF00001052769 cram 9.6 GB
EGAF00001052770 cram 11.7 GB
EGAF00001052771 cram 11.5 GB
EGAF00001052772 cram 8.7 GB
EGAF00001052773 cram 8.6 GB
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EGAF00001052775 cram 9.6 GB
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EGAF00001052777 cram 8.8 GB
EGAF00001052778 cram 12.0 GB
EGAF00001052779 cram 9.1 GB
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EGAF00001052782 cram 9.5 GB
EGAF00001052783 cram 10.9 GB
EGAF00001052784 cram 9.3 GB
EGAF00001052785 cram 8.5 GB
EGAF00001052786 cram 7.8 GB
EGAF00001052787 cram 7.3 GB
EGAF00001052788 cram 8.0 GB
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EGAF00001052791 cram 7.8 GB
EGAF00001052792 cram 13.2 GB
EGAF00001052793 cram 9.3 GB
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EGAF00001052795 cram 9.4 GB
EGAF00001052796 cram 9.3 GB
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EGAF00001052798 cram 7.6 GB
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EGAF00001052808 cram 8.9 GB
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EGAF00001052811 cram 9.2 GB
EGAF00001052812 cram 16.9 GB
EGAF00001052813 cram 11.2 GB
EGAF00001052814 cram 9.2 GB
EGAF00001052815 cram 8.9 GB
EGAF00001052816 cram 12.1 GB
EGAF00001052817 cram 9.4 GB
EGAF00001052818 cram 10.4 GB
EGAF00001052819 cram 6.8 GB
EGAF00001052820 cram 8.6 GB
EGAF00001052821 cram 9.4 GB
EGAF00001052822 cram 7.8 GB
EGAF00001052823 cram 10.4 GB
EGAF00001052824 cram 7.7 GB
EGAF00001052825 cram 10.5 GB
EGAF00001052826 cram 7.8 GB
EGAF00001052827 cram 8.6 GB
EGAF00001052828 cram 9.6 GB
EGAF00001052829 cram 6.8 GB
EGAF00001052830 cram 7.3 GB
EGAF00001052831 cram 8.9 GB
EGAF00001052832 cram 13.1 GB
EGAF00001052833 cram 8.8 GB
EGAF00001052834 cram 7.9 GB
EGAF00001052835 cram 9.6 GB
EGAF00001052836 cram 11.1 GB
EGAF00001052838 cram 14.2 GB
EGAF00001052839 cram 10.7 GB
EGAF00001052840 cram 10.0 GB
EGAF00001052841 cram 9.4 GB
EGAF00001052842 cram 13.1 GB
EGAF00001052843 cram 10.1 GB
EGAF00001052844 cram 6.8 GB
EGAF00001052845 cram 5.2 GB
EGAF00001052846 cram 10.1 GB
EGAF00001052847 cram 4.7 GB
EGAF00001052848 cram 9.0 GB
EGAF00001052849 cram 9.1 GB
EGAF00001052850 cram 9.1 GB
EGAF00001052851 cram 9.2 GB
EGAF00001052852 cram 11.4 GB
EGAF00001052853 cram 8.9 GB
EGAF00001052854 cram 11.1 GB
EGAF00001052855 cram 12.0 GB
EGAF00001052856 cram 7.7 GB
EGAF00001052857 cram 7.8 GB
EGAF00001052858 cram 9.1 GB
EGAF00001052859 cram 12.3 GB
EGAF00001052860 cram 6.2 GB
EGAF00001052861 cram 10.1 GB
EGAF00001052862 cram 9.1 GB
EGAF00001052863 cram 10.3 GB
EGAF00001052864 cram 7.2 GB
EGAF00001052865 cram 6.9 GB
EGAF00001052866 cram 8.5 GB
EGAF00001052867 cram 5.2 GB
EGAF00001052868 cram 10.9 GB
EGAF00001052869 cram 6.5 GB
EGAF00001052870 cram 7.0 GB
EGAF00001052871 cram 8.0 GB
EGAF00001052872 cram 5.9 GB
EGAF00001052873 cram 9.4 GB
EGAF00001052874 cram 6.7 GB
EGAF00001052875 cram 9.1 GB
EGAF00001052876 cram 7.6 GB
EGAF00001052877 cram 7.5 GB
EGAF00001052878 cram 5.6 GB
EGAF00001052879 cram 10.7 GB
EGAF00001052880 cram 11.6 GB
EGAF00001052881 cram 14.3 GB
EGAF00001052882 cram 8.2 GB
EGAF00001052883 cram 10.2 GB
EGAF00001052884 cram 14.8 GB
EGAF00001052885 cram 9.0 GB
EGAF00001052886 cram 8.7 GB
EGAF00001052887 cram 15.6 GB
EGAF00001052888 cram 11.0 GB
EGAF00001052889 cram 8.2 GB
EGAF00001052890 cram 8.2 GB
EGAF00001052892 cram 5.8 GB
EGAF00001052893 cram 7.4 GB
EGAF00001052894 cram 8.8 GB
EGAF00001052895 cram 7.0 GB
EGAF00001052896 cram 9.1 GB
EGAF00001052897 cram 8.0 GB
EGAF00001052898 cram 7.8 GB
EGAF00001052899 cram 6.5 GB
EGAF00001052900 cram 9.1 GB
EGAF00001052901 cram 8.8 GB
EGAF00001052902 cram 7.7 GB
EGAF00001052903 cram 12.7 GB
EGAF00001052904 cram 7.3 GB
EGAF00001052905 cram 7.7 GB
EGAF00001052906 cram 8.5 GB
EGAF00001052907 cram 8.1 GB
EGAF00001052908 cram 7.1 GB
EGAF00001052909 cram 7.5 GB
EGAF00001052910 cram 14.3 GB
EGAF00001052911 cram 10.7 GB
EGAF00001052912 cram 8.3 GB
EGAF00001052913 cram 10.0 GB
EGAF00001052914 cram 10.9 GB
EGAF00001052915 cram 14.1 GB
EGAF00001052916 cram 8.1 GB
EGAF00001052917 cram 12.7 GB
EGAF00001052918 cram 9.6 GB
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EGAF00001052920 cram 7.1 GB
EGAF00001052921 cram 4.7 GB
EGAF00001052922 cram 14.0 GB
EGAF00001052923 cram 10.0 GB
EGAF00001052924 cram 9.2 GB
EGAF00001052925 cram 7.9 GB
EGAF00001052926 cram 8.4 GB
EGAF00001052927 cram 8.7 GB
EGAF00001052928 cram 6.2 GB
EGAF00001052929 cram 10.5 GB
EGAF00001052930 cram 10.5 GB
EGAF00001052931 cram 10.4 GB
EGAF00001052932 cram 8.2 GB
EGAF00001052933 cram 11.5 GB
EGAF00001052934 cram 9.6 GB
EGAF00001052935 cram 8.1 GB
EGAF00001052936 cram 7.8 GB
EGAF00001052937 cram 8.9 GB
EGAF00001052938 cram 14.1 GB
EGAF00001052939 cram 6.1 GB
EGAF00001052940 cram 8.4 GB
EGAF00001052941 cram 11.8 GB
EGAF00001052942 cram 6.6 GB
EGAF00001052943 cram 6.8 GB
EGAF00001052944 cram 7.5 GB
EGAF00001052945 cram 11.3 GB
EGAF00001052946 cram 8.2 GB
EGAF00001052947 cram 8.8 GB
EGAF00001052948 cram 9.7 GB
EGAF00001052949 cram 11.0 GB
EGAF00001052950 cram 7.1 GB
EGAF00001052951 cram 10.1 GB
EGAF00001052952 cram 10.6 GB
EGAF00001052953 cram 13.2 GB
EGAF00001052954 cram 8.6 GB
EGAF00001052955 cram 4.3 GB
EGAF00001052956 cram 14.3 GB
EGAF00001052957 cram 9.5 GB
EGAF00001052958 cram 9.4 GB
EGAF00001052959 cram 9.2 GB
EGAF00001052960 cram 8.0 GB
EGAF00001052961 cram 6.1 GB
EGAF00001052962 cram 8.4 GB
EGAF00001052963 cram 9.9 GB
EGAF00001052964 cram 11.6 GB
EGAF00001052965 cram 10.8 GB
EGAF00001052966 cram 8.2 GB
EGAF00001052967 cram 6.8 GB
EGAF00001052968 cram 8.4 GB
EGAF00001052969 cram 7.3 GB
EGAF00001052970 cram 13.8 GB
EGAF00001052971 cram 8.4 GB
EGAF00001052972 cram 8.5 GB
EGAF00001052973 cram 12.0 GB
EGAF00001052974 cram 9.1 GB
EGAF00001052975 cram 12.8 GB
EGAF00001052976 cram 6.0 GB
EGAF00001052977 cram 5.3 GB
EGAF00001052978 cram 11.4 GB
EGAF00001052979 cram 8.1 GB
EGAF00001052980 cram 9.4 GB
EGAF00001052981 cram 8.2 GB
EGAF00001052982 cram 12.4 GB
EGAF00001052983 cram 4.1 GB
EGAF00001052984 cram 8.6 GB
EGAF00001052985 cram 10.3 GB
EGAF00001052986 cram 7.6 GB
EGAF00001052987 cram 6.3 GB
EGAF00001052988 cram 6.3 GB
EGAF00001052989 cram 9.4 GB
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EGAF00001052991 cram 11.5 GB
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EGAF00001052993 cram 8.0 GB
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EGAF00001052995 cram 7.5 GB
EGAF00001052996 cram 9.5 GB
EGAF00001052997 cram 11.8 GB
EGAF00001052998 cram 10.0 GB
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EGAF00001053002 cram 10.8 GB
EGAF00001053003 cram 10.7 GB
EGAF00001053004 cram 8.1 GB
EGAF00001053005 cram 9.9 GB
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EGAF00001053009 cram 4.7 GB
EGAF00001053010 cram 8.9 GB
EGAF00001053011 cram 7.3 GB
EGAF00001053012 cram 11.0 GB
EGAF00001053013 cram 11.3 GB
EGAF00001053014 cram 6.7 GB
EGAF00001053015 cram 8.4 GB
EGAF00001053016 cram 10.4 GB
EGAF00001053017 cram 8.9 GB
EGAF00001053018 cram 7.9 GB
EGAF00001053019 cram 10.2 GB
EGAF00001053020 cram 10.2 GB
EGAF00001053021 cram 9.1 GB
EGAF00001053022 cram 7.0 GB
EGAF00001053023 cram 8.2 GB
EGAF00001053024 cram 10.0 GB
EGAF00001053025 cram 11.2 GB
EGAF00001053026 cram 7.6 GB
EGAF00001053027 cram 7.3 GB
EGAF00001053028 cram 6.7 GB
EGAF00001053029 cram 8.4 GB
EGAF00001053030 cram 7.4 GB
EGAF00001053031 cram 14.9 GB
EGAF00001053032 cram 8.3 GB
EGAF00001053033 cram 6.0 GB
EGAF00001053034 cram 9.3 GB
EGAF00001053035 cram 12.2 GB
EGAF00001053036 cram 6.8 GB
EGAF00001053037 cram 6.8 GB
EGAF00001053038 cram 10.7 GB
EGAF00001053039 cram 10.3 GB
EGAF00001053040 cram 7.2 GB
EGAF00001053041 cram 7.5 GB
EGAF00001053042 cram 11.7 GB
EGAF00001053043 cram 5.5 GB
EGAF00001053044 cram 8.7 GB
EGAF00001053045 cram 10.7 GB
EGAF00001053046 cram 10.1 GB
EGAF00001053047 cram 8.3 GB
EGAF00001053048 cram 8.9 GB
EGAF00001053049 cram 8.9 GB
EGAF00001053050 cram 8.1 GB
EGAF00001053051 cram 8.7 GB
EGAF00001053052 cram 11.3 GB
EGAF00001053053 cram 6.6 GB
EGAF00001053054 cram 12.3 GB
EGAF00001053055 cram 9.1 GB
EGAF00001053056 cram 7.6 GB
EGAF00001053057 cram 5.8 GB
EGAF00001053058 cram 10.6 GB
EGAF00001053059 cram 8.8 GB
EGAF00001053060 cram 10.0 GB
EGAF00001053061 cram 10.4 GB
EGAF00001053062 cram 7.8 GB
EGAF00001053063 cram 5.4 GB
EGAF00001053064 cram 9.6 GB
EGAF00001053065 cram 7.1 GB
EGAF00001053066 cram 10.8 GB
EGAF00001053067 cram 8.5 GB
EGAF00001053068 cram 6.0 GB
EGAF00001053069 cram 6.4 GB
EGAF00001053070 cram 6.8 GB
EGAF00001053071 cram 5.7 GB
EGAF00001053072 cram 11.8 GB
EGAF00001053073 cram 10.7 GB
EGAF00001053074 cram 10.1 GB
EGAF00001053075 cram 7.4 GB
EGAF00001053076 cram 9.2 GB
EGAF00001053077 cram 7.5 GB
EGAF00001053078 cram 7.7 GB
EGAF00001053079 cram 7.8 GB
EGAF00001053080 cram 7.6 GB
EGAF00001053081 cram 4.9 GB
EGAF00001053082 cram 8.2 GB
EGAF00001053083 cram 5.1 GB
EGAF00001053084 cram 10.2 GB
EGAF00001053085 cram 9.9 GB
EGAF00001053086 cram 12.5 GB
EGAF00001053087 cram 6.8 GB
EGAF00001053088 cram 9.6 GB
EGAF00001053089 cram 8.9 GB
EGAF00001053090 cram 8.9 GB
EGAF00001053091 cram 7.9 GB
EGAF00001053092 cram 9.0 GB
EGAF00001053093 cram 6.7 GB
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EGAF00001053096 cram 7.5 GB
EGAF00001053097 cram 7.1 GB
EGAF00001053098 cram 8.5 GB
EGAF00001053099 cram 12.4 GB
EGAF00001053100 cram 13.7 GB
EGAF00001053101 cram 9.2 GB
EGAF00001053102 cram 5.6 GB
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EGAF00001053106 cram 8.9 GB
EGAF00001053107 cram 9.9 GB
EGAF00001053108 cram 8.8 GB
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EGAF00001053123 cram 9.8 GB
EGAF00001053124 cram 9.4 GB
EGAF00001053125 cram 14.7 GB
EGAF00001053126 cram 17.1 GB
EGAF00001053127 cram 8.1 GB
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EGAF00001053134 cram 8.3 GB
EGAF00001053135 cram 12.9 GB
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EGAF00001053137 cram 9.7 GB
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EGAF00001053141 cram 9.2 GB
EGAF00001053142 cram 9.8 GB
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EGAF00001053155 cram 12.8 GB
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EGAF00001053163 cram 16.4 GB
EGAF00001053164 cram 7.7 GB
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EGAF00001053213 cram 12.3 GB
EGAF00001053214 cram 10.8 GB
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EGAF00001053216 cram 11.9 GB
EGAF00001053217 cram 5.5 GB
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EGAF00001053221 cram 6.1 GB
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EGAF00001053223 cram 11.2 GB
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EGAF00001053226 cram 4.8 GB
EGAF00001053227 cram 14.1 GB
EGAF00001053228 cram 10.3 GB
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EGAF00001053234 cram 9.6 GB
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EGAF00001053237 cram 6.6 GB
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EGAF00001053241 cram 12.4 GB
EGAF00001053242 cram 7.6 GB
EGAF00001053243 cram 8.6 GB
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EGAF00001053251 cram 9.6 GB
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EGAF00001053256 cram 9.0 GB
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EGAF00001053265 cram 7.5 GB
EGAF00001053266 cram 7.4 GB
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EGAF00001053268 cram 6.6 GB
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EGAF00001053279 cram 8.9 GB
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EGAF00001053281 cram 10.2 GB
EGAF00001053282 cram 10.9 GB
EGAF00001053283 cram 9.0 GB
EGAF00001053284 cram 15.0 GB
EGAF00001053285 cram 16.2 GB
EGAF00001053286 cram 10.3 GB
EGAF00001053287 cram 9.8 GB
EGAF00001053288 cram 6.8 GB
EGAF00001053289 cram 6.6 GB
EGAF00001053290 cram 8.9 GB
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EGAF00001053293 cram 10.0 GB
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EGAF00001053295 cram 8.3 GB
EGAF00001053296 cram 15.2 GB
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EGAF00001053298 cram 6.8 GB
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EGAF00001053306 cram 11.9 GB
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EGAF00001053309 cram 9.0 GB
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EGAF00001053313 cram 8.1 GB
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EGAF00001053316 cram 8.5 GB
EGAF00001053317 cram 6.8 GB
EGAF00001053318 cram 9.1 GB
EGAF00001053319 cram 8.5 GB
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EGAF00001053323 cram 8.6 GB
EGAF00001053324 cram 7.8 GB
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EGAF00001053327 cram 9.6 GB
EGAF00001053328 cram 9.0 GB
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EGAF00001053332 cram 7.1 GB
EGAF00001053333 cram 7.9 GB
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EGAF00001053335 cram 5.5 GB
EGAF00001053336 cram 8.0 GB
EGAF00001053337 cram 5.4 GB
EGAF00001053338 cram 10.6 GB
EGAF00001053339 cram 13.7 GB
EGAF00001053340 cram 5.7 GB
EGAF00001053341 cram 18.2 GB
EGAF00001053342 cram 7.1 GB
EGAF00001053343 cram 9.1 GB
EGAF00001053344 cram 7.3 GB
EGAF00001053345 cram 8.7 GB
EGAF00001053346 cram 5.4 GB
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EGAF00001053349 cram 8.1 GB
EGAF00001053350 cram 8.8 GB
EGAF00001053351 cram 9.9 GB
EGAF00001053352 cram 11.4 GB
EGAF00001053353 cram 8.4 GB
EGAF00001053354 cram 9.0 GB
EGAF00001053355 cram 10.0 GB
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EGAF00001053357 cram 8.3 GB
EGAF00001053358 cram 6.8 GB
EGAF00001053359 cram 10.7 GB
EGAF00001053360 cram 7.9 GB
EGAF00001053361 cram 8.7 GB
EGAF00001053362 cram 10.1 GB
EGAF00001053363 cram 8.8 GB
EGAF00001053364 cram 8.6 GB
EGAF00001053365 cram 13.8 GB
EGAF00001053366 cram 12.2 GB
EGAF00001053367 cram 8.3 GB
EGAF00001053368 cram 9.1 GB
EGAF00001053369 cram 6.3 GB
EGAF00001053370 cram 8.1 GB
EGAF00001053371 cram 8.9 GB
EGAF00001053372 cram 15.8 GB
EGAF00001053373 cram 13.5 GB
EGAF00001054825 cram 8.9 GB
EGAF00001054826 cram 6.8 GB
EGAF00001054827 cram 9.9 GB
EGAF00001054828 cram 11.3 GB
EGAF00001054829 cram 7.9 GB
EGAF00001054830 cram 9.3 GB
EGAF00001054831 cram 9.7 GB
EGAF00001054832 cram 10.4 GB
EGAF00001054833 cram 6.9 GB
EGAF00001054834 cram 7.0 GB
EGAF00001054835 cram 13.8 GB
EGAF00001054836 cram 9.7 GB
EGAF00001054837 cram 7.6 GB
EGAF00001054838 cram 7.5 GB
EGAF00001054839 cram 8.3 GB
EGAF00001054840 cram 13.4 GB
EGAF00001054841 cram 11.9 GB
EGAF00001054842 cram 8.0 GB
EGAF00001054843 cram 17.1 GB
EGAF00001054844 cram 9.4 GB
EGAF00001054845 cram 10.8 GB
EGAF00001054846 cram 10.3 GB
EGAF00001054847 cram 6.8 GB
EGAF00001054848 cram 7.1 GB
EGAF00001054849 cram 8.7 GB
EGAF00001054850 cram 9.0 GB
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EGAF00001054852 cram 6.1 GB
EGAF00001054853 cram 10.2 GB
EGAF00001054854 cram 8.6 GB
EGAF00001054855 cram 8.5 GB
EGAF00001054856 cram 11.4 GB
EGAF00001054857 cram 5.8 GB
EGAF00001054858 cram 7.7 GB
EGAF00001054859 cram 8.2 GB
EGAF00001054860 cram 8.6 GB
EGAF00001054861 cram 10.6 GB
EGAF00001054862 cram 7.7 GB
EGAF00001054863 cram 8.3 GB
EGAF00001054864 cram 10.2 GB
EGAF00001054865 cram 9.0 GB
EGAF00001054866 cram 7.3 GB
EGAF00001054867 cram 13.2 GB
EGAF00001054868 cram 9.5 GB
EGAF00001054869 cram 7.4 GB
EGAF00001054870 cram 11.3 GB
EGAF00001054871 cram 8.1 GB
EGAF00001054872 cram 7.0 GB
EGAF00001054873 cram 9.6 GB
EGAF00001054874 cram 7.0 GB
EGAF00001054875 cram 8.7 GB
EGAF00001054876 cram 7.6 GB
EGAF00001054877 cram 9.5 GB
EGAF00001054878 cram 8.5 GB
EGAF00001054879 cram 13.4 GB
EGAF00001054880 cram 6.5 GB
EGAF00001054881 cram 9.4 GB
EGAF00001054882 cram 7.7 GB
EGAF00001054883 cram 10.5 GB
EGAF00001054884 cram 6.4 GB
EGAF00001054899 cram 8.0 GB
EGAF00001054900 cram 10.9 GB
EGAF00001054901 cram 9.1 GB
EGAF00001054902 cram 8.7 GB
EGAF00001054903 cram 9.4 GB
EGAF00001054904 cram 7.9 GB
EGAF00001054905 cram 8.2 GB
EGAF00001054906 cram 8.3 GB
EGAF00001054907 cram 9.1 GB
EGAF00001054908 cram 9.8 GB
EGAF00001054909 cram 9.4 GB
EGAF00001054910 cram 8.3 GB
EGAF00001054911 cram 9.6 GB
EGAF00001054912 cram 8.7 GB
EGAF00001054913 cram 8.4 GB
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EGAF00001054916 cram 7.8 GB
EGAF00001054917 cram 9.6 GB
EGAF00001054918 cram 9.6 GB
EGAF00001054919 cram 10.1 GB
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EGAF00001054921 cram 7.3 GB
EGAF00001054922 cram 7.9 GB
EGAF00001054923 cram 7.6 GB
EGAF00001054924 cram 10.7 GB
EGAF00001054925 cram 8.9 GB
EGAF00001054926 cram 10.4 GB
EGAF00001054927 cram 6.9 GB
EGAF00001054928 cram 14.4 GB
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EGAF00001054930 cram 7.0 GB
EGAF00001054931 cram 10.7 GB
EGAF00001054932 cram 8.0 GB
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EGAF00001054934 cram 9.2 GB
EGAF00001054935 cram 7.4 GB
EGAF00001054936 cram 8.8 GB
EGAF00001054937 cram 7.9 GB
EGAF00001054938 cram 10.2 GB
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EGAF00001054940 cram 8.7 GB
EGAF00001054941 cram 12.4 GB
EGAF00001054942 cram 7.6 GB
EGAF00001054943 cram 11.1 GB
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EGAF00001054945 cram 9.4 GB
EGAF00001054946 cram 8.2 GB
EGAF00001054947 cram 12.4 GB
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EGAF00001054949 cram 8.8 GB
EGAF00001054950 cram 12.3 GB
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EGAF00001054974 cram 10.2 GB
EGAF00001054975 cram 11.2 GB
EGAF00001054976 cram 6.1 GB
EGAF00001054977 cram 12.8 GB
EGAF00001054978 cram 10.9 GB
EGAF00001054979 cram 7.9 GB
EGAF00001054980 cram 7.1 GB
EGAF00001054981 cram 10.6 GB
EGAF00001054982 cram 8.5 GB
EGAF00001054983 cram 7.1 GB
EGAF00001054984 cram 8.0 GB
EGAF00001054985 cram 12.0 GB
EGAF00001054986 cram 8.3 GB
EGAF00001054987 cram 10.1 GB
EGAF00001054988 cram 6.7 GB
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EGAF00001054993 cram 9.4 GB
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EGAF00001055005 cram 12.1 GB
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EGAF00001055013 cram 8.5 GB
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EGAF00001055020 cram 7.8 GB
EGAF00001055021 cram 9.8 GB
EGAF00001055022 cram 7.5 GB
EGAF00001055023 cram 11.9 GB
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EGAF00001055026 cram 11.8 GB
EGAF00001055027 cram 6.7 GB
EGAF00001055028 cram 12.7 GB
EGAF00001055029 cram 9.5 GB
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EGAF00001055032 cram 7.0 GB
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EGAF00001055041 cram 8.7 GB
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EGAF00001055043 cram 9.6 GB
EGAF00001055044 cram 11.9 GB
EGAF00001055045 cram 6.6 GB
EGAF00001055046 cram 8.7 GB
EGAF00001055047 cram 12.6 GB
EGAF00001055048 cram 12.7 GB
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EGAF00001055052 cram 8.1 GB
EGAF00001055053 cram 8.7 GB
EGAF00001055054 cram 9.4 GB
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EGAF00001055056 cram 8.2 GB
EGAF00001055057 cram 18.6 GB
EGAF00001055058 cram 9.2 GB
EGAF00001055059 cram 8.3 GB
EGAF00001055060 cram 10.7 GB
EGAF00001055061 cram 9.0 GB
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EGAF00001055065 cram 5.7 GB
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EGAF00001055069 cram 9.6 GB
EGAF00001055070 cram 11.0 GB
EGAF00001055071 cram 9.2 GB
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EGAF00001055074 cram 7.8 GB
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EGAF00001055077 cram 6.7 GB
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EGAF00001055079 cram 10.6 GB
EGAF00001055080 cram 8.8 GB
EGAF00001055081 cram 7.2 GB
EGAF00001055082 cram 11.5 GB
EGAF00001055083 cram 5.5 GB
EGAF00001055084 cram 8.1 GB
EGAF00001055085 cram 11.5 GB
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EGAF00001055088 cram 10.1 GB
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EGAF00001055090 cram 9.3 GB
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EGAF00001055093 cram 8.6 GB
EGAF00001055094 cram 8.3 GB
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EGAF00001055096 cram 7.2 GB
EGAF00001055097 cram 6.1 GB
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EGAF00001055102 cram 11.2 GB
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EGAF00001055109 cram 12.2 GB
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EGAF00001055171 cram 12.0 GB
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EGAF00001055382 cram 7.7 GB
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EGAF00001055385 cram 8.0 GB
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EGAF00001055401 cram 8.0 GB
EGAF00001055402 cram 10.6 GB
EGAF00001055403 cram 3.2 GB
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EGAF00001055408 cram 8.8 GB
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EGAF00001055417 cram 11.3 GB
EGAF00001055418 cram 9.7 GB
EGAF00001055419 cram 9.7 GB
EGAF00001055420 cram 10.5 GB
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EGAF00001055432 cram 11.5 GB
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EGAF00001055436 cram 6.8 GB
EGAF00001055437 cram 13.9 GB
EGAF00001055438 cram 8.9 GB
EGAF00001055439 cram 14.4 GB
EGAF00001055440 cram 8.2 GB
EGAF00001055441 cram 6.0 GB
EGAF00001055442 cram 9.0 GB
EGAF00001055443 cram 9.6 GB
EGAF00001055444 cram 8.0 GB
EGAF00001055445 cram 8.7 GB
EGAF00001055446 cram 8.9 GB
EGAF00001055447 cram 11.4 GB
EGAF00001055448 cram 9.5 GB
EGAF00001055449 cram 8.0 GB
EGAF00001055450 cram 9.8 GB
EGAF00001055451 cram 8.0 GB
EGAF00001055452 cram 10.3 GB
EGAF00001055453 cram 8.4 GB
EGAF00001055454 cram 7.2 GB
EGAF00001055455 cram 9.3 GB
EGAF00001055456 cram 6.4 GB
EGAF00001055457 cram 6.6 GB
EGAF00001055458 cram 12.3 GB
EGAF00001055459 cram 6.8 GB
EGAF00001055460 cram 7.3 GB
EGAF00001055461 cram 9.7 GB
EGAF00001055462 cram 6.7 GB
EGAF00001055463 cram 10.3 GB
EGAF00001055464 cram 10.7 GB
EGAF00001055465 cram 9.7 GB
EGAF00001055466 cram 9.9 GB
EGAF00001055467 cram 7.0 GB
EGAF00001055468 cram 8.6 GB
EGAF00001055469 cram 10.3 GB
EGAF00001055470 cram 5.4 GB
EGAF00001055471 cram 6.6 GB
EGAF00001055472 cram 7.3 GB
EGAF00001055473 cram 9.7 GB
EGAF00001055474 cram 7.8 GB
EGAF00001055475 cram 8.4 GB
EGAF00001055476 cram 7.5 GB
EGAF00001055477 cram 9.1 GB
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EGAF00001055481 cram 10.1 GB
EGAF00001055482 cram 11.2 GB
EGAF00001055483 cram 9.8 GB
EGAF00001055484 cram 7.0 GB
EGAF00001055485 cram 10.0 GB
EGAF00001055486 cram 9.8 GB
EGAF00001055487 cram 8.8 GB
EGAF00001055488 cram 12.6 GB
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EGAF00001055490 cram 10.7 GB
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EGAF00001055492 cram 8.8 GB
EGAF00001055493 cram 11.8 GB
EGAF00001055494 cram 12.3 GB
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EGAF00001055497 cram 7.7 GB
EGAF00001055498 cram 12.4 GB
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EGAF00001055517 cram 12.5 GB
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EGAF00001055521 cram 9.0 GB
EGAF00001055522 cram 7.8 GB
EGAF00001055523 cram 16.5 GB
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EGAF00001055525 cram 4.7 GB
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EGAF00001055530 cram 10.5 GB
EGAF00001055531 cram 10.1 GB
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EGAF00001055533 cram 6.9 GB
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EGAF00001055536 cram 6.9 GB
EGAF00001055537 cram 8.4 GB
EGAF00001055538 cram 10.3 GB
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EGAF00001055541 cram 9.7 GB
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EGAF00001055543 cram 12.1 GB
EGAF00001055544 cram 10.4 GB
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EGAF00001055583 cram 10.9 GB
EGAF00001055584 cram 12.2 GB
EGAF00001055585 cram 8.7 GB
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EGAF00001055604 cram 9.6 GB
EGAF00001055605 cram 11.9 GB
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EGAF00001055612 cram 7.7 GB
EGAF00001055613 cram 11.1 GB
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EGAF00001055621 cram 9.9 GB
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EGAF00001055631 cram 7.9 GB
EGAF00001055632 cram 9.1 GB
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EGAF00001055634 cram 11.0 GB
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EGAF00001055636 cram 13.6 GB
EGAF00001055637 cram 8.1 GB
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EGAF00001055654 cram 15.8 GB
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EGAF00001055704 cram 20.2 GB
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EGAF00001055716 cram 18.8 GB
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EGAF00001055758 cram 29.8 GB
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EGAF00001055810 cram 9.6 GB
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EGAF00001055815 cram 10.0 GB
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EGAF00001055822 cram 10.2 GB
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EGAF00001055826 cram 9.1 GB
EGAF00001055827 cram 12.9 GB
EGAF00001055828 cram 8.1 GB
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EGAF00001055831 cram 9.8 GB
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EGAF00001055838 cram 10.0 GB
EGAF00001055839 cram 16.6 GB
EGAF00001055840 cram 10.0 GB
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EGAF00001055845 cram 7.2 GB
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EGAF00001277274 cram 11.5 GB
EGAF00001277275 cram 10.3 GB
EGAF00001277276 cram 9.5 GB
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EGAF00001334125 cram 6.6 GB
EGAF00001334126 cram 8.1 GB
EGAF00001334127 cram 5.7 GB
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EGAF00001334129 cram 8.3 GB
EGAF00001334130 cram 7.2 GB
EGAF00001334131 cram 5.5 GB
EGAF00001334132 cram 7.0 GB
EGAF00001334133 cram 5.9 GB
EGAF00001334134 cram 6.1 GB
EGAF00001334135 cram 7.3 GB
EGAF00001334136 cram 8.2 GB
EGAF00001334137 cram 7.2 GB
EGAF00001334138 cram 6.6 GB
EGAF00001334139 cram 7.4 GB
EGAF00001334140 cram 6.6 GB
EGAF00001334141 cram 8.9 GB
EGAF00001334142 cram 6.3 GB
EGAF00001334143 cram 6.6 GB
EGAF00001334144 cram 5.2 GB
EGAF00001334145 cram 6.0 GB
EGAF00001334146 cram 11.1 GB