Adeno-associated virus in the liver: natural history and consequences in tumor development

Dataset ID Technology Samples
EGAD00001004484 Illumina HiSeq 2000 20

Dataset Description

Adeno-associated virus (AAV) is a defective mono-stranded DNA virus, endemic in human population (35-80%). Recurrent clonal AAV2 insertions are associated with the pathogenesis of rare human hepatocellular carcinoma (HCC) developed on normal liver. This study aimed to characterize the natural history of AAV infection in the liver and its consequence in tumor development.
In silico analyses using viral capture data explored viral variants and new clonal insertions. Clonal AAV insertions were positive selected during HCC development on non-cirrhotic liver challenging the notion of AAV as a non-pathogenic virus.

Who controls access to this dataset

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ICGC Data Access Compliance Office
Contact person: helpdesk
Email: dcc-support [at] icgc [dot] org
Access information:
More details: EGAC00001000010


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