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Non-invasive prenatal diagnosis by genome-wide haplotyping of cell-free plasma DNA

This dataset contains a total of 10 families and 51 samples presented in 'Non-invasive prenatal diagnosis by genome-wide haplotyping of cell-free plasma DNA' study, in which 9 of them are cfDNA samples and the rest of samples are gDNA samples. All the samples are targeted sequencing data with a custom 45Mb capture library . Raw pair-end fastq files for each sample is available.

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Data policy

DATA ACCESS AGREEMENT Definitions Authorised Personnel: The individuals at the User Institution to whom KU Leuven grants access to the Data. This includes the User, the individuals listed in Appendix II and any other individuals for whom the User Institution subsequently requests access to the Data. Details of the initial Authorised Personnel are set out in Appendix II. Data: The managed access datasets to which the User Institution has requested access. Data Producers: KU Leuven and the collaborators listed in Appendix I responsible for the development, organisation, and oversight of these Data. External Collaborator: A collaborator of the User, working for an institution other than the User Institution. Project: The project for which the User Institution has requested access to these Data. A description of the Project is set out in Appendix II. Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. Research Participant: An individual whose data form part of these Data. Research Purposes: Shall mean research that is seeking to advance the understanding of genetics and genomics, including the treatment of disorders, and work on statistical methods that may be applied to such research. User: The principal investigator for the Project. User Institution(s): The Institution that has requested access to the Data. 1. The User Institution agrees to only use these Data for the purpose of the Project (described in Appendix II) and only for Research Purposes. The User Institution further agrees that it will only use these Data for Research Purposes which are within the limitations (if any) set out in Appendix I. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. Without prejudice to the generality of the foregoing, the User Institution agrees to use at least the measures set out in Appendix I to protect these Data. 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The User Institution agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorised Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 6. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 7. The User Institution agrees to follow the Fort Lauderdale Guidelines (http://www.wellcome.ac.uk/stellent/groups/corporatesite/@policy_communications/documents/web_document/wtd003207.pdf ) and the Toronto Statement (http://www.nature.com/nature/journal/v461/n7261/full/461168a.html). This includes but is not limited to recognising the contribution of the Data Producers and including a proper acknowledgement in all reports or publications resulting from the use of these Data. 8. The User Institution agrees to follow the Publication Policy in Appendix III. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analysing these Data. 9. The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusion drawn directly from these Data. 10. The User Institution can elect to perform further research that would add intellectual and resource capital to these data and decide to obtain intellectual property rights on these downstream discoveries. In this case, the User Institution agrees to implement licensing policies that will not obstruct further research and to follow the U.S. National Institutes of Health Best Practices for the Licensing of Genomic Inventions (2005) (https://www.icgc.org/files/daco/NIH_BestPracticesLicensingGenomicInventions_2005_en.pdf ) in conformity with the Organisation for Economic Co-operation and Development Guidelines for the Licensing of the Genetic Inventions (2006) (http://www.oecd.org/science/biotech/36198812.pdf ). 11. The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 12. The User Institution will notify KU Leuven within 30 days of any changes or departures of Authorised Personnel. 13. The User Institution will notify KU Leuven prior to any significant changes to the protocol for the Project. 14. The User Institution will notify KU Leuven as soon as it becomes aware of a breach of the terms or conditions of this agreement. 15. KU Leuven may terminate this agreement by written notice to the User Institution. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the User Institution from retaining these data for archival purpose in conformity with audit or legal requirements. 16. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. As an example, this may include specific provisions relating to the Data required by Data Producers other than KU Leuven. In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement. 17. If requested, the User Institution will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. 18. The User Institution agrees to distribute a copy of these terms to the Authorised Personnel. The User Institution will procure that the Authorised Personnel comply with the terms of this agreement. 19. This agreement (and any dispute, controversy, proceedings or claim of whatever nature arising out of this agreement or its formation) shall be construed, interpreted and governed by the laws of Belgium and shall be subject to the exclusive jurisdiction of the Belgium courts.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001003634 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00002453935 fastq.gz 1.7 GB
EGAF00002453936 fastq.gz 1.6 GB
EGAF00002453937 fastq.gz 3.4 GB
EGAF00002453938 fastq.gz 3.3 GB
EGAF00002453939 fastq.gz 2.3 GB
EGAF00002453940 fastq.gz 2.3 GB
EGAF00002453941 fastq.gz 2.9 GB
EGAF00002453942 fastq.gz 3.0 GB
EGAF00002453943 fastq.gz 3.0 GB
EGAF00002453944 fastq.gz 3.1 GB
EGAF00002453945 fastq.gz 2.7 GB
EGAF00002453946 fastq.gz 2.7 GB
EGAF00002453947 fastq.gz 2.6 GB
EGAF00002453948 fastq.gz 2.7 GB
EGAF00002453949 fastq.gz 3.5 GB
EGAF00002453950 fastq.gz 3.6 GB
EGAF00002453951 fastq.gz 3.5 GB
EGAF00002453952 fastq.gz 3.6 GB
EGAF00002453953 fastq.gz 3.4 GB
EGAF00002453954 fastq.gz 3.4 GB
EGAF00002453955 fastq.gz 6.9 GB
EGAF00002453956 fastq.gz 7.0 GB
EGAF00002453957 fastq.gz 3.6 GB
EGAF00002453958 fastq.gz 3.7 GB
EGAF00002453959 fastq.gz 2.5 GB
EGAF00002453960 fastq.gz 2.6 GB
EGAF00002453961 fastq.gz 2.4 GB
EGAF00002453962 fastq.gz 2.5 GB
EGAF00002453963 fastq.gz 1.8 GB
EGAF00002453964 fastq.gz 1.9 GB
EGAF00002453965 fastq.gz 4.6 GB
EGAF00002453966 fastq.gz 4.7 GB
EGAF00002453967 fastq.gz 4.7 GB
EGAF00002453968 fastq.gz 4.8 GB
EGAF00002453969 fastq.gz 2.4 GB
EGAF00002453970 fastq.gz 2.4 GB
EGAF00002453971 fastq.gz 2.4 GB
EGAF00002453972 fastq.gz 2.4 GB
EGAF00002453973 fastq.gz 2.0 GB
EGAF00002453974 fastq.gz 2.0 GB
EGAF00002453975 fastq.gz 2.4 GB
EGAF00002453976 fastq.gz 2.4 GB
EGAF00002453977 fastq.gz 1.7 GB
EGAF00002453978 fastq.gz 1.7 GB
EGAF00002453979 fastq.gz 1.9 GB
EGAF00002453980 fastq.gz 1.9 GB
EGAF00002453981 fastq.gz 5.0 GB
EGAF00002453982 fastq.gz 5.1 GB
EGAF00002453983 fastq.gz 2.1 GB
EGAF00002453984 fastq.gz 2.2 GB
EGAF00002453985 fastq.gz 5.8 GB
EGAF00002453986 fastq.gz 5.9 GB
EGAF00002453987 fastq.gz 2.1 GB
EGAF00002453988 fastq.gz 2.1 GB
EGAF00002453989 fastq.gz 4.4 GB
EGAF00002453990 fastq.gz 4.5 GB
EGAF00002453991 fastq.gz 3.2 GB
EGAF00002453992 fastq.gz 3.3 GB
EGAF00002453993 fastq.gz 3.3 GB
EGAF00002453994 fastq.gz 3.4 GB
EGAF00002453995 fastq.gz 2.7 GB
EGAF00002453996 fastq.gz 2.8 GB
EGAF00002453997 fastq.gz 4.7 GB
EGAF00002453998 fastq.gz 4.8 GB
EGAF00002453999 fastq.gz 3.0 GB
EGAF00002454000 fastq.gz 3.0 GB
EGAF00002454001 fastq.gz 2.7 GB
EGAF00002454002 fastq.gz 2.8 GB
EGAF00002454003 fastq.gz 6.7 GB
EGAF00002454004 fastq.gz 6.8 GB
EGAF00002454005 fastq.gz 3.9 GB
EGAF00002454006 fastq.gz 3.9 GB
EGAF00002454007 fastq.gz 3.6 GB
EGAF00002454008 fastq.gz 3.6 GB
EGAF00002454009 fastq.gz 15.3 GB
EGAF00002454010 fastq.gz 15.6 GB
EGAF00002454011 fastq.gz 3.1 GB
EGAF00002454012 fastq.gz 3.1 GB
EGAF00002454013 fastq.gz 4.1 GB
EGAF00002454014 fastq.gz 4.1 GB
EGAF00002454015 fastq.gz 1.9 GB
EGAF00002454016 fastq.gz 1.9 GB
EGAF00002454017 fastq.gz 4.1 GB
EGAF00002454018 fastq.gz 4.2 GB
EGAF00002454019 fastq.gz 2.7 GB
EGAF00002454020 fastq.gz 2.7 GB
EGAF00002454021 fastq.gz 3.5 GB
EGAF00002454022 fastq.gz 3.6 GB
EGAF00002454023 fastq.gz 3.4 GB
EGAF00002454024 fastq.gz 3.4 GB
EGAF00002454025 fastq.gz 11.8 GB
EGAF00002454026 fastq.gz 12.1 GB
EGAF00002454027 fastq.gz 2.6 GB
EGAF00002454028 fastq.gz 2.6 GB
EGAF00002454029 fastq.gz 3.0 GB
EGAF00002454030 fastq.gz 3.1 GB
EGAF00002454031 fastq.gz 2.0 GB
EGAF00002454032 fastq.gz 2.2 GB
EGAF00002454033 fastq.gz 5.1 GB
EGAF00002454034 fastq.gz 5.6 GB
EGAF00002454035 fastq.gz 3.6 GB
EGAF00002454036 fastq.gz 4.0 GB
102 Files (378.9 GB)