Sequencing of LCM-derived microbiopsies from 20 women who underwent risk-reducing reduction mastectomies due to germline BRCA1/2. Goal to assess the mutational burden, spectrum, and clonal dynamics within the tissue. Targeted data will be used as a driver and clonality screen, highly clonal or driver-containing samples will subsequently be sent for whole-genome sequencing. Results from this portion of the study will be compared to women who had cosmetic breast reduction surgeries and those with cancer. . This dataset contains all the data available for this study on 2020-01-29.

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Dataset

MutWP5: CRUK Mutographs of Cancer: Breast: BRCA Carriers (Targeted) (2020-01-29)

Dataset ID	Technology	Samples
EGAD00001005920	Illumina HiSeq 4000	49

Dataset Description

Sequencing of LCM-derived microbiopsies from 20 women who underwent risk-reducing reduction mastectomies due to germline BRCA1/2. Goal to assess the mutational burden, spectrum, and clonal dynamics within the tissue. Targeted data will be used as a driver and clonality screen, highly clonal or driver-containing samples will subsequently be sent for whole-genome sequencing. Results from this portion of the study will be compared to women who had cosmetic breast reduction surgeries and those with cancer. .
This dataset contains all the data available for this study on 2020-01-29.

Label	Code	Version
general research use	DUO:0000042	2021-02-23
institution specific restriction	DUO:0000028	2021-02-23
publication required	DUO:0000019	2021-02-23
user specific restriction	DUO:0000026	2021-02-23

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WTSI CGP Data access committee
Contact person: Data Sharing
Email: datasharing [at] sanger [dot] ac [dot] uk
More details: EGAC00001000000

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