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Profiling heterogeneity in Human derived IPSC-neurons (2020-05-18)

The impact of genetic variants on molecular pathways that give rise to neurodegenerative diseases such as Alzheimer's and Parkinson's is best elucidated in the appropriate cell types and molecular contexts. Existing studies have focused on bulk profiling of mixed cell types, but have ignored assaying genetic effects across development and cell differentiation. At the core of this proposal is the idea to use single-cell assays to study genetic effects during differentiation of dopaminergic and cortical neurons to identify the sequence of molecular events from variants to healthy and diseased cell states in a cell-specific manner. 1) This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute please see . This dataset contains all the data available for this study on 2020-05-18.

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Wellcome Trust Sanger Institute Data Sharing Policy

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001002885 Transcriptome Analysis

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00003942976 cram 5.5 GB
EGAF00003942977 cram 4.1 GB
EGAF00003942978 cram 5.4 GB
EGAF00003942979 cram 7.2 GB
EGAF00003942980 cram 6.4 GB
EGAF00003942981 cram 4.5 GB
EGAF00003942982 cram 7.0 GB
EGAF00003942983 cram 3.9 GB
EGAF00003942984 cram 7.3 GB
EGAF00003942985 cram 4.0 GB
EGAF00003942986 cram 7.3 GB
EGAF00003942987 cram 3.9 GB
EGAF00003942988 cram 5.7 GB
EGAF00003942989 cram 3.2 GB
EGAF00003942990 cram 5.2 GB
EGAF00003942991 cram 6.7 GB
EGAF00003942992 cram 7.1 GB
EGAF00003942993 cram 5.0 GB
EGAF00003942994 cram 4.6 GB
EGAF00003942995 cram 4.9 GB
EGAF00003942996 cram 6.5 GB
EGAF00003942997 cram 3.2 GB
EGAF00003942998 cram 4.9 GB
EGAF00003942999 cram 4.8 GB
EGAF00003943000 cram 5.9 GB
EGAF00003943001 cram 6.4 GB
EGAF00003943002 cram 6.4 GB
EGAF00003943003 cram 3.5 GB
EGAF00003943004 cram 4.2 GB
EGAF00003943005 cram 7.7 GB
EGAF00003943006 cram 4.7 GB
EGAF00003943007 cram 4.9 GB
EGAF00003943008 cram 4.5 GB
EGAF00003943009 cram 5.9 GB
EGAF00003943010 cram 6.4 GB
EGAF00003943011 cram 4.3 GB
EGAF00003943012 cram 6.2 GB
EGAF00003943013 cram 4.8 GB
EGAF00003943014 cram 4.7 GB
EGAF00003943015 cram 5.1 GB
EGAF00003943016 cram 5.0 GB
EGAF00003943017 cram 4.9 GB
EGAF00003943018 cram 6.1 GB
EGAF00003943019 cram 4.4 GB
EGAF00003943020 cram 2.8 GB
EGAF00003943021 cram 6.7 GB
EGAF00003943022 cram 5.2 GB
EGAF00003943023 cram 6.4 GB
EGAF00003943024 cram 5.1 GB
EGAF00003943025 cram 7.5 GB
EGAF00003943026 cram 5.0 GB
EGAF00003943027 cram 3.7 GB
EGAF00003943028 cram 4.1 GB
EGAF00003943029 cram 4.2 GB
EGAF00003943030 cram 7.0 GB
EGAF00003943031 cram 4.9 GB
EGAF00003943032 cram 5.4 GB
EGAF00003943033 cram 970.0 MB
EGAF00003943034 cram 6.6 GB
EGAF00003943035 cram 4.8 GB
EGAF00003943036 cram 4.1 GB
EGAF00003943037 cram 5.0 GB
EGAF00003943038 cram 5.2 GB
EGAF00003943039 cram 3.1 GB
EGAF00003943040 cram 5.4 GB
EGAF00003943041 cram 7.1 GB
EGAF00003943042 cram 6.3 GB
EGAF00003943043 cram 3.9 GB
EGAF00003943044 cram 7.2 GB
EGAF00003943045 cram 5.0 GB
EGAF00003943046 cram 4.5 GB
EGAF00003943047 cram 4.6 GB
EGAF00003943048 cram 5.3 GB
EGAF00003943049 cram 6.0 GB
EGAF00003943050 cram 6.1 GB
EGAF00003943051 cram 6.3 GB
EGAF00003943052 cram 4.7 GB
EGAF00003943053 cram 4.7 GB
EGAF00003943054 cram 7.8 GB
EGAF00003943055 cram 6.7 GB
EGAF00003943056 cram 5.5 GB
EGAF00003943057 cram 4.0 GB
EGAF00003943058 cram 7.2 GB
EGAF00003943059 cram 6.8 GB
EGAF00003943060 cram 5.2 GB
EGAF00003943061 cram 4.5 GB
EGAF00003943062 cram 7.8 GB
EGAF00003943063 cram 5.7 GB
EGAF00003943064 cram 6.9 GB
EGAF00003943065 cram 1.8 GB
EGAF00003943066 cram 8.4 GB
EGAF00003943067 cram 6.3 GB
EGAF00003943068 cram 5.3 GB
EGAF00003943069 cram 6.5 GB
EGAF00003943070 cram 6.7 GB
EGAF00003943071 cram 4.5 GB
EGAF00003943072 cram 5.3 GB
EGAF00003943073 cram 7.1 GB
EGAF00003943074 cram 6.6 GB
EGAF00003943075 cram 5.5 GB
EGAF00003943076 cram 5.7 GB
EGAF00003943077 cram 4.2 GB
EGAF00003943078 cram 5.3 GB
EGAF00003943079 cram 6.4 GB
EGAF00003943080 cram 7.1 GB
EGAF00003943081 cram 4.7 GB
EGAF00003943082 cram 7.5 GB
EGAF00003943083 cram 5.4 GB
EGAF00003943084 cram 5.3 GB
EGAF00003943085 cram 6.8 GB
EGAF00003943086 cram 5.3 GB
EGAF00003943087 cram 5.1 GB
EGAF00003943088 cram 7.1 GB
EGAF00003943089 cram 6.3 GB
EGAF00003943090 cram 3.5 GB
EGAF00003943091 cram 5.3 GB
EGAF00003943092 cram 5.9 GB
EGAF00003943093 cram 4.6 GB
EGAF00003943094 cram 7.6 GB
EGAF00003943095 cram 4.4 GB
EGAF00003943096 cram 5.0 GB
EGAF00003943097 cram 4.8 GB
EGAF00003943098 cram 5.7 GB
EGAF00003943099 cram 6.8 GB
EGAF00003943100 cram 5.8 GB
EGAF00003943101 cram 7.1 GB
EGAF00003943102 cram 7.2 GB
EGAF00003943103 cram 3.2 GB
EGAF00003943104 cram 7.3 GB
EGAF00003943105 cram 69.8 MB
EGAF00003943106 cram 7.5 GB
EGAF00003943107 cram 9.5 GB
EGAF00003943108 cram 7.4 GB
EGAF00003943109 cram 5.8 GB
EGAF00003943110 cram 4.1 GB
EGAF00003943111 cram 6.1 GB
EGAF00003943112 cram 7.3 GB
EGAF00003943113 cram 5.2 GB
EGAF00003943114 cram 5.0 GB
EGAF00003943115 cram 4.8 GB
EGAF00003943116 cram 5.1 GB
EGAF00003943117 cram 5.6 GB
EGAF00003943118 cram 6.2 GB
EGAF00003943119 cram 5.7 GB
EGAF00003943120 cram 6.1 GB
EGAF00003943121 cram 5.5 GB
EGAF00003943122 cram 7.3 GB
EGAF00003943123 cram 3.8 GB
EGAF00003943124 cram 7.2 GB
EGAF00003943125 cram 4.8 GB
EGAF00003943126 cram 6.6 GB
EGAF00003943127 cram 3.8 GB
EGAF00003943128 cram 5.9 GB
EGAF00003943129 cram 5.5 GB
EGAF00003943130 cram 6.5 GB
EGAF00003943131 cram 2.3 GB
EGAF00003943132 cram 7.4 GB
EGAF00003943133 cram 4.7 GB
EGAF00003943134 cram 6.0 GB
EGAF00003943135 cram 1.7 GB
EGAF00003943136 cram 5.6 GB
EGAF00003943137 cram 4.5 GB
EGAF00003943138 cram 7.1 GB
EGAF00003943139 cram 2.6 GB
EGAF00003943140 cram 6.4 GB
EGAF00003943141 cram 4.2 GB
EGAF00003943142 cram 5.4 GB
EGAF00003943143 cram 3.8 GB
168 Files (918.0 GB)