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Dataset

Somatic mutations reveal embryonic genetic bottlenecks generating placental mosaicism

Dataset ID	Technology	Samples
EGAD00001006337	HiSeq X Ten,Illumina NovaSeq 6000	278

Dataset Description

The human placenta harbours chromosomal aberrations that are absent from the fetus in one to two percent of pregnancies. This confined mosaicism suggests that embryonic genetic bottlenecks exist, which phylogenetically segregate placental tissue. Here, we studied the somatic genetic landscape of human placentas by whole genome sequencing of 86 placental biopsies and of 106 microdissections.

Data Use Conditions

IS PUB US

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Label	Code	Version
general research use	DUO:0000042	2021-02-23
institution specific restriction	DUO:0000028	2021-02-23
publication required	DUO:0000019	2021-02-23
user specific restriction	DUO:0000026	2021-02-23

Who controls access to this dataset

For each dataset that requires controlled access, there is a corresponding Data Access Committee (DAC) who determine access permissions. Access to actual data files is not managed by the EGA. If you need to request access to this data set, please contact:

WTSI CGP Data access committee
Contact person: Data Sharing
Email: datasharing [at] sanger [dot] ac [dot] uk
Access information: https://edam.sanger.ac.uk/
More details: EGAC00001000000

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This dataset is featured in 3 studies

Studies are experimental investigations of a particular phenomenon. e.g. case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients. Click on one of the Study IDs below to find out more.

Study ID	Study Title	Study Type
EGAS00001003297	Placental genomics	Cancer Genomics
EGAS00001003457	GermCellTumour	Whole Genome Sequencing
EGAS00001003549	Placental mosaicism	Cancer Genomics

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