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Single-nucleus Transcriptome of Down Syndrome Brains (short-read)

29 DS and Control brain samples were prepared using the 10X Genomics Single Cell 3' v3 kit. The cDNA libraries were sequenced on an Illumina Novaseq 6000.

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Chun Lab Data Access Policy

DATA ACCESS AGREEMENT These terms and conditions govern access to the managed access datasets (details of which are set out in Appendix I) to which the User Institution has requested access. The User Institution agrees to be bound by these terms and conditions. Definitions Authorised Personnel: The individuals at the User Institution to whom the Chun Lab DAC grants access to the Data. This includes the User, the individuals listed in Appendix II and any other individuals for whom the User Institution subsequently requests access to the Data. Details of the initial Authorised Personnel are set out in Appendix II. Data: The managed access datasets to which the User Institution has requested access. Data Producers: The Chun Lab DAC and the collaborators listed in Appendix I responsible for the development, organisation, and oversight of these Data. External Collaborator: A collaborator of the User, working for an institution other than the User Institution. Project: The project for which the User Institution has requested access to these Data. A description of the Project is set out in Appendix II. Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. Research Participant: An individual whose data form part of these Data. Research Purposes: Shall mean research that is seeking to advance the understanding of genetics and genomics, including the treatment of disorders, and work on statistical methods that may be applied to such research. User: The principal investigator for the Project. User Institution(s): The Institution that has requested access to the Data. Chun Lab DAC: Data Access Committee, Laboratory of Jerold Chun, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 1. The User Institution agrees to only use these Data for the purpose of the Project (described in Appendix II) and only for Research Purposes. The User Institution further agrees that it will only use these Data for Research Purposes which are within the limitations (if any) set out in Appendix I. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. Without prejudice to the generality of the foregoing, the User Institution agrees to use at least the measures set out in Appendix I to protect these Data. 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The User Institution agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorised Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 6. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 7. The User Institution agrees to follow the Fort Lauderdale Guidelines ( ) and the Toronto Statement ( This includes but is not limited to recognising the contribution of the Data Producers and including a proper acknowledgement in all reports or publications resulting from the use of these Data. 8. The User Institution agrees to follow the Publication Policy in Appendix III. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analysing these Data. 9. The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusion drawn directly from these Data. 10. The User Institution can elect to perform further research that would add intellectual and resource capital to these data and decide to obtain intellectual property rights on these downstream discoveries. In this case, the User Institution agrees to implement licensing policies that will not obstruct further research and to follow the U.S. National Institutes of Health Best Practices for the Licensing of Genomic Inventions (2005) ( ) in conformity with the Organisation for Economic Co-operation and Development Guidelines for the Licensing of the Genetic Inventions (2006) ( ). 11. The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 12. The User Institution will notify the Chun Lab DAC within 30 days of any changes or departures of Authorised Personnel. 13. The User Institution will notify the Chun Lab DAC prior to any significant changes to the protocol for the Project. 14. The User Institution will notify the Chun Lab DAC as soon as it becomes aware of a breach of the terms or conditions of this agreement. 15. The Chun Lab DAC may terminate this agreement by written notice to the User Institution. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the User Institution from retaining these data for archival purpose in conformity with audit or legal requirements. 16. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. As an example, this may include specific provisions relating to the Data required by Data Producers other than the Chun Lab DAC. In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement. 17. If requested, the User Institution will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. 18. The User Institution agrees to distribute a copy of these terms to the Authorised Personnel. The User Institution will procure that the Authorised Personnel comply with the terms of this agreement.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001005691 Other
ID File Type Size Located in
EGAF00005564525 fastq.gz 26.8 GB
EGAF00005564526 fastq.gz 23.5 GB
EGAF00005564529 fastq.gz 32.2 GB
EGAF00005564530 fastq.gz 28.2 GB
EGAF00005564531 fastq.gz 37.1 GB
EGAF00005564532 fastq.gz 34.7 GB
EGAF00005564534 fastq.gz 29.5 GB
EGAF00005564535 fastq.gz 27.3 GB
EGAF00005564546 fastq.gz 32.6 GB
EGAF00005564547 fastq.gz 28.6 GB
EGAF00005564549 fastq.gz 27.5 GB
EGAF00005564550 fastq.gz 24.0 GB
EGAF00005564551 fastq.gz 31.6 GB
EGAF00005564552 fastq.gz 27.7 GB
EGAF00005564559 fastq.gz 28.4 GB
EGAF00005564560 fastq.gz 24.9 GB
EGAF00005564562 fastq.gz 28.8 GB
EGAF00005564563 fastq.gz 25.1 GB
EGAF00005564564 fastq.gz 29.2 GB
EGAF00005564565 fastq.gz 25.6 GB
EGAF00005564577 fastq.gz 20.6 GB
EGAF00005564578 fastq.gz 18.8 GB
EGAF00005564579 fastq.gz 27.3 GB
EGAF00005564580 fastq.gz 25.5 GB
EGAF00005564583 fastq.gz 29.0 GB
EGAF00005564584 fastq.gz 27.1 GB
EGAF00005564585 fastq.gz 31.6 GB
EGAF00005564586 fastq.gz 27.5 GB
EGAF00005564587 fastq.gz 29.7 GB
EGAF00005564588 fastq.gz 26.0 GB
EGAF00005564589 fastq.gz 30.2 GB
EGAF00005564590 fastq.gz 26.7 GB
EGAF00005564605 fastq.gz 27.1 GB
EGAF00005564606 fastq.gz 25.6 GB
EGAF00005564607 fastq.gz 18.3 GB
EGAF00005564608 fastq.gz 17.5 GB
EGAF00005564609 fastq.gz 34.4 GB
EGAF00005564610 fastq.gz 30.5 GB
EGAF00005564611 fastq.gz 30.5 GB
EGAF00005564612 fastq.gz 26.7 GB
EGAF00005564613 fastq.gz 34.2 GB
EGAF00005564614 fastq.gz 29.9 GB
EGAF00005564615 fastq.gz 30.1 GB
EGAF00005564616 fastq.gz 26.4 GB
EGAF00005564619 fastq.gz 30.8 GB
EGAF00005564620 fastq.gz 27.1 GB
EGAF00005564621 fastq.gz 29.7 GB
EGAF00005564622 fastq.gz 26.0 GB
EGAF00005564624 fastq.gz 31.3 GB
EGAF00005564625 fastq.gz 27.5 GB
EGAF00005564627 fastq.gz 28.6 GB
EGAF00005564628 fastq.gz 24.6 GB
EGAF00005564630 fastq.gz 30.0 GB
EGAF00005564631 fastq.gz 26.3 GB
EGAF00005564633 fastq.gz 33.4 GB
EGAF00005564634 fastq.gz 29.6 GB
EGAF00005564636 fastq.gz 29.4 GB
EGAF00005564637 fastq.gz 25.9 GB
58 Files (1.6 TB)