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Unravelling the contribution of HIF pathway and its therapeutic potential in human AML leukemia-initiating cells

We performed single cell RNA sequencing (scRNA-seq) from bone marrow on 11 pediatric (0-14 years-old) and adolescent and young adult (AYA) (15-39 years-old) de novo AML samples (Dx) (4 inv(16), 3 t(8;21) and 4 rMLL). In addition, for some patients also relapse sample was sequenced (2 inv(16), 2 t(8;21) and 3 rMLL). Cells were sorted into CD34+/CD38- and CD34-/CD38+ and sequenced separately.

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Unravelling the contribution of HIF pathway and its therapeutic potential in human AML leukemia-initiating cells Data Access and Use Agreement

Genomic and anti-tumor immune evolution of breast cancer Data Access and Use Agreement This agreement governs the terms on which access will be granted to the next-generation sequencing data generated as a result of the Genomic and anti-tumor immune evolution of breast cancer study, deposited by members of the Data Access Committee. In signing this agreement, you are agreeing with the Data Access Committee to be bound by the terms and conditions set out in this agreement. NOW THEREFORE in consideration of the access to the Data provided by the Data Access Committee to User Institution, and for other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, and intending to be legally bound hereby, the parties hereto agree as follows: Definitions: Application: means an application made by an entity (including You) to request access to the Data for a specific project and/or purpose. Data: means non personal data including all and any human genetic and raw expression data obtained from the Data Access Committee (which is currently available through the European Genome-phenome Archive). Data Access Committee (DAC): means the members listed in Appendix I, which are responsible for the development, organisation, oversight of these Data, and consider Applications. Data Subject: means a person, who has been informed of the purpose for which the Data was collected, is currently held, and the purposes for which it can and will be distributed and disclosed, and has given his/her informed consent thereto. All references to individual Data Subjects have been removed and the Data is no longer personal data. User means a researcher whose User Institution has signed this Data Access Agreement and has received acknowledgement of the acceptance of its Application. Publications means, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. User Institution means the organisation at which the User is employed, affiliated or enrolled User Institution is referred to within this Agreement as “You” (and “Your” shall be construed accordingly). Terms and Conditions: 1. You agree to preserve, at all times, the confidentiality and privacy of information and Data pertaining to Data Subjects. In particular, you undertake not to use, or attempt to use the Data to compromise or otherwise breach or infringe the confidentiality and privacy of information on Data Subjects. 2. You agree not to attempt to link the Data to any other data source on the same samples, link the Data to any person or otherwise identify any Data Subject from the Data. We have taken organisational and technical measures to ensure this cannot happen. 3. You agree not to transfer or disclose the Data, in whole or part to others, except to persons within the User Institution for the fulfilment of the Purpose as reasonably necessary for Data/safety monitoring or programme management. If You wish to disclose the Data to a collaborator outside the User Institution, the third party must make a separate Application for access to the Data and enter into a separate Agreement. 4. You agree to use the Data for the advancement of medical research, and solely for the approved purpose and project described in Your Application and for no other purpose, which is attached hereto as Appendix III (the “Purpose”); provided that any use of the Data beyond the scope of the Purpose will require a new Application, approval and Agreement. You agree to destroy the raw data once the project is completed, and upon request of the DAC, provide written certification of such destruction. 5. You agree that Data may be reissued from time to time, with suitable versioning. If the reissue is at the request of sample donors and/or other ethical scrutiny, you will destroy earlier versions of the Data, and upon request of the DAC, provide written certification of such destruction. 6. You agree to acknowledge in any work or Publications based in whole or part on the Data, the published paper from which the Data derives, the version of the Data, and the role of the DAC, in accordance with the Publications Policy attached as Appendix II. 7. You agree and acknowledge that the DAC members, the original Data creators, depositors or copyright holders: a) bear no legal responsibility or liability for the accuracy or comprehensiveness of the Data, or from any use of the Data including further analysis or interpretation of such Data; and b) shall have no liability for any direct or indirect, consequential, or incidental damages or losses whatsoever arising out of Your use of the Data, or from the unavailability of, or lack of access to, the Data for whatever reason; and c) disclaim any and all representations, conditions or warranties (either express, implied or statutory) regarding the Data, including accuracy of the Data or that the Data corresponds with a particular description or is fit for a particular purpose. 8. You shall indemnify, hold harmless and defend each of the DAC members and their respective directors, officers, employees and agents against any and all claims (including all associated legal fees and disbursements actually incurred) arising out of this Agreement, including without limitation against any damages or losses, consequential or otherwise, arising in any manner at all from or out of Your use of the Data. Section 8 shall not apply to any public body or institution that is prevented by applicable laws from providing indemnification. 9. You understand and acknowledge that the Data is owned by the DAC and protected by copyright, database rights and other intellectual property rights owned by the DAC. You agree that you shall not reproduce or copy the Data, except as reasonably required to carry out the Purpose and for no other purpose, or sell all or any part of the Data in any circumstances. 10. You recognize that nothing in this Agreement shall operate to transfer to You any ownership or intellectual property rights relating to the Data. 11. You accept that this Agreement will terminate immediately upon any breach of this Agreement by You and You will be required to destroy or return any Data, and upon request, provide written certification of such destruction. For the avoidance of doubt clause 3, 7, 8, 14, 15 will continue to operate in full force and effect. 12. You accept that it may be necessary for the DAC to alter the terms of this Agreement from time to time in order to address new concerns. In this event, one of the DAC members will contact You to inform You of any changes and You agree that Your continued use of the Data shall be dependent on the parties entering into a new version of the Agreement. 13. You agree that you will submit a report to the Data Access Committee, if requested, on completion of the Purpose. The Data Access Committee agrees to treat the report and all information, data, results, and conclusions contained within such report as confidential information belonging to the User Institution. 14. You agree that the Data is protected by and subject to applicable international laws, which may include without limitation the UK Data Protection Act 1998, and that You are responsible for ensuring compliance with any such laws. The Data Access Committee reserve the right to request and inspect Your data security and management documentation to ensure the adequacy of data protection measures in countries that have no privacy legislation comparable with that contained herein. 15. You agree to follow the Fort Lauderdale Guidelines (http://www.wellcome.ac.uk/stellent/groups/corporatesite/@policy_communications/documents/web_document/wtd003207.pdf) and the Toronto Statement (http://www.nature.com/nature/journal/v461/n7261/full/461168a.html). This includes but is not limited to recognising the contribution of the DAC and including a proper acknowledgement in all reports or publications resulting from the use of these Data. 16. Part or all of any section of this Agreement that is indefinite, invalid, illegal or otherwise voidable or unenforceable may be severed and the balance of this agreement will continue in full force and effect. Appendix I Membership Data Access Committee Leticia De Mattos-Arruda, IrsiCaixa Foundation Carla Dos Anjos De Souza, IrsiCaixa Foundation Juan Blanco Heredia, IrsiCaixa Foundation   Appendix II Publications Policy Any use of Data must be acknowledged using the following wording: "This study makes use of data generated by the “Genomic and anti-tumor immune evolution of breast cancer ”.   Appendix III Application (approved by the Data Access Committee)   For and on behalf of User Institution: Signature of Institutional or Administrative Authority: Print name: User Institution: Date: For and on behalf of User: Although I am not a party to this Agreement I have read, understood and acknowledge its terms and conditions. Name of Applicant(s): Signature of Applicant(s): Date: WHEN SUBMITTING THIS DOCUMENT, PLEASE INCLUDE ALL PAGES OF THE AGREEMENT WITH THIS SIGNATURE PAGE

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001005980 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00005788171 fastq.gz 875.7 MB
EGAF00005788172 fastq.gz 1.9 GB
EGAF00005788173 fastq.gz 2.1 GB
EGAF00005788174 fastq.gz 4.6 GB
EGAF00005788175 fastq.gz 900.1 MB
EGAF00005788176 fastq.gz 2.0 GB
EGAF00005788177 fastq.gz 2.1 GB
EGAF00005788178 fastq.gz 4.6 GB
EGAF00005788179 fastq.gz 1.6 GB
EGAF00005788180 fastq.gz 3.6 GB
EGAF00005788181 fastq.gz 1.6 GB
EGAF00005788182 fastq.gz 3.6 GB
EGAF00005788183 fastq.gz 2.1 GB
EGAF00005788184 fastq.gz 4.6 GB
EGAF00005788185 fastq.gz 1.7 GB
EGAF00005788186 fastq.gz 3.7 GB
EGAF00005788187 fastq.gz 2.1 GB
EGAF00005788188 fastq.gz 4.7 GB
EGAF00005788189 fastq.gz 2.1 GB
EGAF00005788190 fastq.gz 4.7 GB
EGAF00005788191 fastq.gz 2.2 GB
EGAF00005788192 fastq.gz 5.0 GB
EGAF00005788193 fastq.gz 1.4 GB
EGAF00005788194 fastq.gz 3.2 GB
EGAF00005788195 fastq.gz 2.8 GB
EGAF00005788196 fastq.gz 6.5 GB
EGAF00005788197 fastq.gz 2.7 GB
EGAF00005788198 fastq.gz 6.3 GB
EGAF00005788199 fastq.gz 2.0 GB
EGAF00005788200 fastq.gz 4.7 GB
EGAF00005788201 fastq.gz 1.2 GB
EGAF00005788202 fastq.gz 2.6 GB
EGAF00005788203 fastq.gz 1.8 GB
EGAF00005788204 fastq.gz 3.9 GB
EGAF00005788205 fastq.gz 1.8 GB
EGAF00005788206 fastq.gz 4.1 GB
EGAF00005788207 fastq.gz 2.3 GB
EGAF00005788208 fastq.gz 5.2 GB
EGAF00005788209 fastq.gz 2.4 GB
EGAF00005788210 fastq.gz 5.3 GB
EGAF00005788211 fastq.gz 2.3 GB
EGAF00005788212 fastq.gz 5.0 GB
EGAF00005788213 fastq.gz 2.4 GB
EGAF00005788214 fastq.gz 5.1 GB
EGAF00005788215 fastq.gz 1.6 GB
EGAF00005788216 fastq.gz 3.6 GB
EGAF00005788217 fastq.gz 1.8 GB
EGAF00005788218 fastq.gz 4.2 GB
EGAF00005788219 fastq.gz 1.6 GB
EGAF00005788220 fastq.gz 3.6 GB
EGAF00005788221 fastq.gz 1.2 GB
EGAF00005788222 fastq.gz 2.8 GB
EGAF00005788223 fastq.gz 2.1 GB
EGAF00005788224 fastq.gz 4.7 GB
EGAF00005788225 fastq.gz 1.8 GB
EGAF00005788226 fastq.gz 4.1 GB
EGAF00005788227 fastq.gz 2.3 GB
EGAF00005788228 fastq.gz 5.4 GB
EGAF00005788229 fastq.gz 1.8 GB
EGAF00005788230 fastq.gz 4.2 GB
EGAF00005788231 fastq.gz 751.0 MB
EGAF00005788232 fastq.gz 1.7 GB
EGAF00005788233 fastq.gz 1.4 GB
EGAF00005788234 fastq.gz 3.2 GB
EGAF00005788235 fastq.gz 740.7 MB
EGAF00005788236 fastq.gz 1.7 GB
EGAF00005788237 fastq.gz 2.5 GB
EGAF00005788238 fastq.gz 5.6 GB
EGAF00005788239 fastq.gz 1.0 GB
EGAF00005788240 fastq.gz 2.4 GB
EGAF00005788241 fastq.gz 2.3 GB
EGAF00005788242 fastq.gz 5.5 GB
EGAF00005788243 fastq.gz 2.4 GB
EGAF00005788244 fastq.gz 5.4 GB
EGAF00005788245 fastq.gz 2.0 GB
EGAF00005788246 fastq.gz 4.7 GB
EGAF00005788247 fastq.gz 1.6 GB
EGAF00005788248 fastq.gz 3.7 GB
EGAF00005788249 fastq.gz 2.2 GB
EGAF00005788250 fastq.gz 5.0 GB
EGAF00005788251 fastq.gz 2.1 GB
EGAF00005788252 fastq.gz 4.5 GB
EGAF00005788253 fastq.gz 2.4 GB
EGAF00005788254 fastq.gz 5.6 GB
EGAF00005788255 fastq.gz 1.8 GB
EGAF00005788256 fastq.gz 4.2 GB
EGAF00005788257 fastq.gz 2.0 GB
EGAF00005788258 fastq.gz 4.5 GB
EGAF00005788259 fastq.gz 683.1 MB
EGAF00005788260 fastq.gz 1.5 GB
EGAF00005788261 fastq.gz 2.0 GB
EGAF00005788262 fastq.gz 4.7 GB
EGAF00005788263 fastq.gz 1.7 GB
EGAF00005788264 fastq.gz 3.8 GB
EGAF00005788265 fastq.gz 2.3 GB
EGAF00005788266 fastq.gz 5.0 GB
EGAF00005788267 fastq.gz 2.4 GB
EGAF00005788268 fastq.gz 5.5 GB
EGAF00005788269 fastq.gz 897.0 MB
EGAF00005788270 fastq.gz 2.0 GB
EGAF00005788271 fastq.gz 1.1 GB
EGAF00005788272 fastq.gz 2.5 GB
EGAF00005788273 fastq.gz 2.2 GB
EGAF00005788274 fastq.gz 5.1 GB
EGAF00005788275 fastq.gz 885.5 MB
EGAF00005788276 fastq.gz 2.0 GB
EGAF00005788277 fastq.gz 2.2 GB
EGAF00005788278 fastq.gz 5.1 GB
EGAF00005788279 fastq.gz 1.2 GB
EGAF00005788280 fastq.gz 2.5 GB
EGAF00005788281 fastq.gz 2.5 GB
EGAF00005788282 fastq.gz 5.8 GB
EGAF00005788283 fastq.gz 2.4 GB
EGAF00005788284 fastq.gz 5.7 GB
EGAF00005788285 fastq.gz 2.0 GB
EGAF00005788286 fastq.gz 4.4 GB
EGAF00005788287 fastq.gz 2.4 GB
EGAF00005788288 fastq.gz 5.4 GB
EGAF00005788289 fastq.gz 1.1 GB
EGAF00005788290 fastq.gz 2.4 GB
EGAF00005788291 fastq.gz 1.7 GB
EGAF00005788292 fastq.gz 3.8 GB
EGAF00005788293 fastq.gz 2.0 GB
EGAF00005788294 fastq.gz 4.4 GB
EGAF00005788295 fastq.gz 2.1 GB
EGAF00005788296 fastq.gz 4.4 GB
EGAF00005788297 fastq.gz 2.1 GB
EGAF00005788298 fastq.gz 4.6 GB
EGAF00005788299 fastq.gz 796.0 MB
EGAF00005788300 fastq.gz 1.8 GB
EGAF00005788301 fastq.gz 2.1 GB
EGAF00005788302 fastq.gz 4.6 GB
EGAF00005788303 fastq.gz 2.1 GB
EGAF00005788304 fastq.gz 4.5 GB
EGAF00005788305 fastq.gz 1.3 GB
EGAF00005788306 fastq.gz 3.0 GB
EGAF00005788307 fastq.gz 1.1 GB
EGAF00005788308 fastq.gz 2.5 GB
EGAF00005788309 fastq.gz 1.6 GB
EGAF00005788310 fastq.gz 3.7 GB
EGAF00005788311 fastq.gz 2.0 GB
EGAF00005788312 fastq.gz 4.6 GB
EGAF00005788313 fastq.gz 1.6 GB
EGAF00005788314 fastq.gz 3.6 GB
EGAF00005788315 fastq.gz 2.1 GB
EGAF00005788316 fastq.gz 4.9 GB
EGAF00005788317 fastq.gz 2.1 GB
EGAF00005788318 fastq.gz 4.9 GB
EGAF00005788319 fastq.gz 2.3 GB
EGAF00005788320 fastq.gz 5.0 GB
EGAF00005788321 fastq.gz 673.7 MB
EGAF00005788322 fastq.gz 1.5 GB
EGAF00005788323 fastq.gz 822.8 MB
EGAF00005788324 fastq.gz 1.9 GB
EGAF00005788325 fastq.gz 2.5 GB
EGAF00005788326 fastq.gz 5.6 GB
EGAF00005788327 fastq.gz 2.5 GB
EGAF00005788328 fastq.gz 5.6 GB
EGAF00005788329 fastq.gz 2.3 GB
EGAF00005788330 fastq.gz 5.5 GB
EGAF00005788331 fastq.gz 2.4 GB
EGAF00005788332 fastq.gz 5.4 GB
EGAF00005788333 fastq.gz 2.4 GB
EGAF00005788334 fastq.gz 5.6 GB
164 Files (490.6 GB)