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Whole exome sequencing of non-small cell lung cancer patient-derived xenografts

Non-small cell lung cancer (NSCLC) is the leading cause of cancer deaths worldwide. Only a fraction of NSCLC harbour actionable driver mutations and there is an urgent need for patient-derived model systems that will enable the development of new targeted therapies. We generated NSCLC patient-derived xenografts (PDXs) that recapitulate the histology and molecular features of primary NSCLC. Here, we completed whole exome sequencing on 122 NSCLC PDXs.

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University health network data access commitee; EGAC00001000912

DATA ACCESS AGREEMENT These terms and conditions govern access to the managed access datasets (details of which are set out in Appendix I) to which the User Institution has requested access. The User Institution agrees to be bound by these terms and conditions. Definitions Authorized Personnel: The individuals at the User Institution to whom the Data Access Committee (DAC) grants access to the Data. This includes the User, and those individuals under the direct supervision of the User, as well as any other individuals listed in Appendix II. Details of the initial Authorized Personnel are set out in Appendix II. Data: The managed access datasets to which the User Institution has requested access, as is outlined in the Appendix 1 attached hereto. Data Producers: The Principal Investigator responsible for the creation of this Data and other investigators responsible for the creation of this Data. External Collaborator: A collaborator of the User, working for an institution other than the User Institution. Project: The project for which the User Institution has requested access to these Data. A description of the Project is set out in Appendix II. Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. Research Participant: An individual whose data form part of these Data. Research Purposes: Shall mean research that is seeking to advance the understanding of genetics and genomics, including the treatment of disorders, and work on statistical methods that may be applied to such research. Research Ethics Board Approval shall mean approval of the Project by the User Institution’s research ethics board or other research ethics board or independent review board for whom said User Institution obtains research ethics approval(s). User: The principal investigator for the Project. User Institution(s): The Institution that has requested access to the Data. University Health Network: The University Health Network (UHN) is the largest clinical and research hospital in Canada. UHN is affiliated with the University of Toronto and is a member of the Toronto Academic Health Science Network. 1. The User Institution agrees to only use these Data for the purpose of the Project (described in Appendix II) within the Research Purposes, and only in accordance with Research Ethics Board Approval, and any conditions or restrictions imposed pursuant to such Research Ethics Board Approval. The User Institution further agrees that it will only use these Data for Research Purposes which are within the limitations (if any) set out in Appendix I. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise breach the anonymity of the Research Participants, including agreeing to not attempt to re-identify or contact any Research Participant. Without prejudice to the generality of the foregoing, the User Institution agrees to use at least the measures set out in Appendix I to protect the Data. Despite the confidentiality of the Data, the User Institution may publish aggregate data and other results arising from use of the Data and may refer to the Data by reference to the accession number(s) as documented in Appendix I in further support of any publication resulting from use of said Data. 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of re-identification. 4. The User Institution agrees not to link or combine these Data to other information or archived data in a way that could re-identify the Research Participants, even if access to that other data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorized Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data and enter into a separate Data Access Agreement. 6. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding or provision of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 7. The User Institution agrees recognize the contribution of the Data Producers and include a proper acknowledgement in all reports or publications resulting from the use of these Data. 8. The User Institution agrees to follow the Publication Policy in Appendix III. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analyzing these Data. 9. The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusion drawn directly from these Data. 10. The User Institution can elect to perform further research that would add intellectual and resource capital to these data and decide to obtain intellectual property rights on these downstream discoveries. 11. The User Institution agrees to destroy/delete the Data held, once it is no longer being used for the Project, or in the event that the User departs the User Institution or otherwise can no longer complete the Project, with the proviso that the User Institution can retain a copy of the Data for archival purposes only in conformity with audit or legal requirements. 12. The User Institution will notify the DAC within 30 days of any changes or departures of the User, at which point the Project will terminate and the User Institution delete or destroy the Data (as per Section 11) unless otherwise agreed by the DAC. 13. The User Institution will notify the DAC prior to any significant changes to the protocol for the Project. 14. The User Institution will notify the DAC as soon as it becomes aware of a breach of the terms or conditions of this agreement. 15. Either party may terminate this agreement by written notice to the other party. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the User Institution from retaining these data for archival purpose in conformity with audit or legal requirements. 16. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement. 17. If requested, the User Institution will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. 18. The User Institution agrees to distribute a copy of these terms to the Authorized Personnel. The User Institution will procure that the Authorized Personnel comply with the terms of this agreement. 19. The Parties agree to remain silent on choice of law.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001006068 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00006012401 bam 18.2 GB
EGAF00006012402 bam 15.0 GB
EGAF00006012403 bam 26.6 GB
EGAF00006012404 bam 20.9 GB
EGAF00006012405 bam 22.9 GB
EGAF00006012406 bam 47.9 GB
EGAF00006012407 bam 12.4 GB
EGAF00006012408 bam 14.4 GB
EGAF00006012409 bam 13.4 GB
EGAF00006012410 bam 29.1 GB
EGAF00006012411 bam 13.1 GB
EGAF00006012412 bam 10.2 GB
EGAF00006012413 bam 13.5 GB
EGAF00006012414 bam 17.5 GB
EGAF00006012415 bam 14.6 GB
EGAF00006012416 bam 15.8 GB
EGAF00006012417 bam 28.8 GB
EGAF00006012418 bam 19.3 GB
EGAF00006012419 bam 12.3 GB
EGAF00006012420 bam 10.9 GB
EGAF00006012421 bam 30.0 GB
EGAF00006012422 bam 8.2 GB
EGAF00006012423 bam 13.3 GB
EGAF00006012424 bam 13.8 GB
EGAF00006012425 bam 7.5 GB
EGAF00006012426 bam 7.0 GB
EGAF00006012427 bam 15.7 GB
EGAF00006012428 bam 14.3 GB
EGAF00006012429 bam 26.9 GB
EGAF00006012430 bam 14.1 GB
EGAF00006012431 bam 13.9 GB
EGAF00006012432 bam 14.8 GB
EGAF00006012433 bam 13.3 GB
EGAF00006012434 bam 11.2 GB
EGAF00006012435 bam 15.9 GB
EGAF00006012436 bam 13.6 GB
EGAF00006012437 bam 15.7 GB
EGAF00006012438 bam 17.3 GB
EGAF00006012439 bam 16.2 GB
EGAF00006012440 bam 15.3 GB
EGAF00006012441 bam 15.0 GB
EGAF00006012442 bam 14.1 GB
EGAF00006012443 bam 6.1 GB
EGAF00006012444 bam 28.9 GB
EGAF00006012445 bam 16.5 GB
EGAF00006012446 bam 11.6 GB
EGAF00006012447 bam 14.7 GB
EGAF00006012448 bam 16.5 GB
EGAF00006012449 bam 6.3 GB
EGAF00006012450 bam 17.9 GB
EGAF00006012451 bam 7.6 GB
EGAF00006012452 bam 9.6 GB
EGAF00006012453 bam 6.5 GB
EGAF00006012454 bam 14.7 GB
EGAF00006012455 bam 14.9 GB
EGAF00006012456 bam 18.0 GB
EGAF00006012457 bam 12.4 GB
EGAF00006012458 bam 15.0 GB
EGAF00006012459 bam 8.1 GB
EGAF00006012460 bam 25.1 GB
EGAF00006012461 bam 18.7 GB
EGAF00006012462 bam 22.0 GB
EGAF00006012463 bam 12.8 GB
EGAF00006012464 bam 42.7 GB
EGAF00006012465 bam 15.5 GB
EGAF00006012466 bam 15.7 GB
EGAF00006012467 bam 24.0 GB
EGAF00006012468 bam 12.2 GB
EGAF00006012469 bam 14.6 GB
EGAF00006012470 bam 12.8 GB
EGAF00006012471 bam 8.5 GB
EGAF00006012472 bam 11.4 GB
EGAF00006012473 bam 13.8 GB
EGAF00006012474 bam 27.7 GB
EGAF00006012475 bam 11.9 GB
EGAF00006012476 bam 18.7 GB
EGAF00006012477 bam 17.7 GB
EGAF00006012478 bam 5.4 GB
EGAF00006012479 bam 10.4 GB
EGAF00006012480 bam 15.8 GB
EGAF00006012481 bam 13.8 GB
EGAF00006012482 bam 13.0 GB
EGAF00006012483 bam 14.9 GB
EGAF00006012484 bam 16.1 GB
EGAF00006012485 bam 22.6 GB
EGAF00006012486 bam 9.5 GB
EGAF00006012487 bam 8.7 GB
EGAF00006012488 bam 16.6 GB
EGAF00006012489 bam 13.2 GB
EGAF00006012490 bam 11.4 GB
EGAF00006012491 bam 15.5 GB
EGAF00006012492 bam 10.9 GB
EGAF00006012493 bam 6.2 GB
EGAF00006012494 bam 10.5 GB
EGAF00006012495 bam 18.3 GB
EGAF00006012496 bam 13.6 GB
EGAF00006012497 bam 17.6 GB
EGAF00006012498 bam 6.3 GB
EGAF00006012499 bam 18.4 GB
EGAF00006012500 bam 15.8 GB
EGAF00006012501 bam 18.6 GB
EGAF00006012502 bam 15.5 GB
EGAF00006012503 bam 16.6 GB
EGAF00006012504 bam 21.8 GB
EGAF00006012505 bam 8.6 GB
EGAF00006012506 bam 16.0 GB
EGAF00006012507 bam 15.5 GB
EGAF00006012508 bam 18.8 GB
EGAF00006012509 bam 16.6 GB
EGAF00006012510 bam 43.3 GB
EGAF00006012511 bam 16.6 GB
EGAF00006012512 bam 68.7 GB
EGAF00006012513 bam 12.7 GB
EGAF00006012514 bam 14.8 GB
EGAF00006012515 bam 8.2 GB
EGAF00006012516 bam 12.5 GB
EGAF00006012517 bam 5.4 GB
EGAF00006012518 bam 49.3 GB
EGAF00006012519 bam 11.9 GB
EGAF00006012520 bam 14.7 GB
EGAF00006012521 bam 52.4 GB
EGAF00006012522 bam 15.4 GB
122 Files (2.0 TB)