Annotated VCF Files for WGS of ASD Cohort with 68 Individuals from 22 families, enriched for recent shared ancestry

• None DUO:0000001 (version: 2021-02-23)data use permissionA data item that is used to indicate consent permissions for datasets and/or materials, and relates to the purposes for which datasets and/or material might be removed, stored or used.
• IRB DUO:0000021 (version: 2021-02-23)ethics approval requiredThis data use modifier indicates that the requestor must provide documentation of local IRB/ERB approval.
• US DUO:0000026 (version: 2021-02-23)user specific restrictionThis data use modifier indicates that use is limited to use by approved users.
• PS DUO:0000027 (version: 2021-02-23)project specific restrictionThis data use modifier indicates that use is limited to use within an approved project.

This agreement governs the terms on which access will be granted to the whole genome sequence data generated and published in this study: Analysis of recent shared ancestry in a familial cohort identifies coding and noncoding autism spectrum disorder variants, Tuncay et al., npj Genomic Medicine, 2022. In signing this agreement, you are agreeing to be bound by the terms and conditions of access set out in this agreement. For the sake of clarity, the terms of access set out in this agreement apply both to the User and the User’s Institution (as defined below). User Institution and User are referred to within the agreement as “you” and “your” shall be construed accordingly.

Definitions: Data means all and any human genetic data obtained under this Database Access Agreement. Data Subject means a person, who has been informed of the purpose for which the Data is held and has given his/her informed consent thereto. User means a researcher whose User Institution has previously completed this Data Access Agreement and has received acknowledgement of its acceptance. Publications means, without limitation, articles published in print journals, electronic journals, reviews, books, posters, and other written and verbal presentations of research performed using the Data. User Institution means the organization at which the User is employed, affiliated with, or enrolled. Terms and Conditions: In signing this Agreement: 1. You agree to use the Data only for the advancement of medical research in accordance with the approved proposal that you submitted unless otherwise required by law. 2. You agree not to use the Data for the creation of products for sale or for any commercial purpose, without the prior negotiation of a commercial license with the University of Texas Southwestern Medical Center. 3. You agree to preserve, at all times, the confidentiality of information and Data pertaining to Data Subjects. In particular, you undertake not to use, or attempt to use, the Data to compromise or otherwise infringe the confidentiality of information on Data Subjects and their right to privacy. You agree that you will not use the Data to re-identify any individual. 4. You agree not to attempt to link the Data provided under this agreement to other information or archive data available for the data sets provided, even if access to that data has been formally granted to you, or it is freely available without restriction, without specific permission being sought from the relevant access committees. 5. You agree not to transfer or disclose the Data, in whole or part, or any identifiable material derived from the Data, to others, except as necessary for data/safety monitoring or program management. Should you wish to share the Data with a collaborator from another institution, that third party must make a separate application for access to the Data. 6. You agree to use the Data for the approved purpose and project described in your application. Use of the Data for a new purpose or project will require a new application and approval. 7. You accept that Data will be reissued from time to time, with suitable versioning. If the reissue is at the request of sample donors and/or other ethical scrutiny, you will destroy earlier versions of the Data. 8. You agree to abide by the terms outlined in the “Publications Policy”, as set out in Schedule 1. 9. You accept that the University of Texas Southwestern Medical Center and The Hospital for Sick Children, the original data creators, depositors or copyright holders, or the funders of the Data or any part of the Data supplied: a) bear no legal responsibility for the accuracy or comprehensiveness of the Data; and b) accept no liability for indirect, consequential, or incidental damages or losses arising from use of the Data, or from the unavailability of, or break in access to, the Data for whatever reason. 11. You understand and acknowledge that the Data is protected by copyright and other intellectual property rights, and that duplication, except as reasonably required to carry out your research with the Data, or sale of all or part of the Data on any media is not permitted. 12. You recognize that nothing in this agreement shall operate to transfer to the User Institution any intellectual property rights relating to the Data. The User Institution has the right to develop intellectual property based on comparisons with their own data. 13. You accept that this agreement will terminate immediately upon any breach of this agreement by you and you will be required to destroy any Data held. 14. You accept that it may be necessary for the University of Texas Southwestern Medical Center, The Hospital for Sick Children, or their appointed agents to alter the terms of this agreement from time to time in order to address new concerns. In this event, the University of Texas Southwestern Medical Center, The Hospital for Sick Children, or their appointed agent will notify you of any changes, and you agree that your continued use of the Data shall be dependent on the parties entering into a new version of the Agreement. 15. You agree that you will submit a report to the University of Texas Southwestern Medical Center, if requested, on completion of the agreed purpose. The University of Texas Southwestern Medical Center agrees to treat the report and all information, data, results, and conclusions contained within such a report as confidential information belonging to the User Institution. 16. You accept that the Data are protected by and subject to laws in various international jurisdictions, including without limitation laws in the USA, EAA, and Canada, and that you are responsible for ensuring compliance with any such applicable law. The Data Access Committee reserves the right to request and inspect data security and management documentation to ensure the adequacy of data protection measures in countries that have no national laws comparable to that which pertain in the USA, EAA, and Canada. 17. Any legal action, claim or other legal proceeding commenced by one party hereto against another party, arising out of this Agreement, shall be commenced in the courts of the jurisdiction in which the responding party is situated; and for the purposes of such proceeding, this Agreement shall be governed by, and shall be interpreted, construed, and enforced, in accordance with the laws of that same jurisdiction. SCHEDULE 1 Publications Policy The University of Texas Southwestern Medical Center anticipates that data generated from the project will be used by others, such as required for developing new analytical methods, in understanding patterns of polymorphism, and in guiding selection of genomic regions harboring genes involved in autism spectrum disorder and related disorders. Authors who use data from the project must include an acknowledgement using the following wording "This study makes use of data generated by the laboratory of Dr. Maria Chahrour at the University of Texas Southwestern Medical Center and by the Autism Speaks MSSNG Project, including The Hospital for Sick Children (Toronto)." and cite the relevant publication: Analysis of recent shared ancestry in a familial cohort identifies coding and noncoding autism spectrum disorder variants, Tuncay et al., npj Genomic Medicine, 2022. Users should note that the University of Texas Southwestern Medical Center and The Hospital for Sick Children bear no responsibility for the further analysis or interpretation of these data, over and above that published by the University of Texas Southwestern Medical Center and/or The Hospital for Sick Children. For and on behalf of User: Name of Applicant: _____________________________________ _____________________________________ _____________________________________ Signature of Applicant(s): _____________________________________ _____________________________________ _____________________________________ Date: _____________________________________ For and on behalf of User Institution: Signature of Institutional or Administrative Authority: ______________________________________ Print name: ______________________________________ User Institution: ______________________________________ Date: ______________________________________ WHEN SUBMITTING THIS DOCUMENT, PLEASE INCLUDE ALL PAGES OF THE AGREEMENT WITH THIS SIGNATURE PAGE