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Drug screen in iPSC-Neurons identifies nucleoside analogs as inhibitors of (G4C2)n expression in C9orf72 ALS/FTD

To investigate the mode of action and potential side-effects we analyzed differential gene expression in Postmitotic C9orf72 iPSC-Neurons by RNAseq. The cells were treated in a 2 dose regime at 10 µm in 0.1 % DMSO for 9 days. Compound treated iPSC-Neurons were washed with PBS, frozen on dry ice and stored at -80°C until RNA isolation. The RNA was isolated using miRNA Mini Kit (Qiagen) using 700 μl of Qiazol. A total of 250 ng of RNA per sample was processed for mRNA library preparation as per the manufacturer’s instructions for Illumina® Stranded mRNA Prep Ligation to be used with the IDT® for Illumina® RNA UD Indexes Set B and sequenced using NextSeq 500/550 High Output Kit v2.5 (Illumina) on NextSeq 550 (Illumina). The data was processed and analyzed using CLC genomics workbench (Version 21.0.3, Qiagen)

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The complete study is being published in a peer-review study and hence the data is available after the associated research paper is published.

The complete study is being published in a peer-review study and hence the data is available after the associated research paper is published.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001006138 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00006134176 fastq.gz 1.1 GB
EGAF00006134177 fastq.gz 1.2 GB
EGAF00006134178 fastq.gz 954.5 MB
EGAF00006134179 fastq.gz 972.3 MB
EGAF00006134180 fastq.gz 902.2 MB
EGAF00006134181 fastq.gz 912.4 MB
EGAF00006134182 fastq.gz 992.2 MB
EGAF00006134183 fastq.gz 1.0 GB
EGAF00006134184 fastq.gz 1.0 GB
EGAF00006134185 fastq.gz 1.0 GB
EGAF00006134186 fastq.gz 908.3 MB
EGAF00006134187 fastq.gz 908.5 MB
EGAF00006134188 fastq.gz 987.1 MB
EGAF00006134189 fastq.gz 994.9 MB
EGAF00006134190 fastq.gz 1.0 GB
EGAF00006134191 fastq.gz 1.0 GB
EGAF00006134192 fastq.gz 966.0 MB
EGAF00006134193 fastq.gz 976.6 MB
EGAF00006134194 fastq.gz 998.6 MB
EGAF00006134195 fastq.gz 995.6 MB
EGAF00006134196 fastq.gz 1.0 GB
EGAF00006134197 fastq.gz 1.0 GB
EGAF00006134198 fastq.gz 916.8 MB
EGAF00006134199 fastq.gz 926.0 MB
EGAF00006134200 fastq.gz 911.6 MB
EGAF00006134201 fastq.gz 921.9 MB
EGAF00006134202 fastq.gz 991.1 MB
EGAF00006134203 fastq.gz 998.3 MB
EGAF00006134204 fastq.gz 860.2 MB
EGAF00006134205 fastq.gz 863.0 MB
EGAF00006134206 fastq.gz 754.1 MB
EGAF00006134207 fastq.gz 762.0 MB
EGAF00006134208 fastq.gz 949.4 MB
EGAF00006134209 fastq.gz 961.0 MB
EGAF00006134210 fastq.gz 965.5 MB
EGAF00006134211 fastq.gz 972.1 MB
EGAF00006134212 fastq.gz 952.1 MB
EGAF00006134213 fastq.gz 946.8 MB
EGAF00006134214 fastq.gz 919.9 MB
EGAF00006134215 fastq.gz 931.8 MB
EGAF00006134216 fastq.gz 903.9 MB
EGAF00006134217 fastq.gz 912.0 MB
EGAF00006134218 fastq.gz 884.4 MB
EGAF00006134219 fastq.gz 895.2 MB
EGAF00006134220 fastq.gz 923.7 MB
EGAF00006134221 fastq.gz 929.8 MB
EGAF00006134222 fastq.gz 977.8 MB
EGAF00006134223 fastq.gz 986.3 MB
EGAF00006134224 fastq.gz 1.1 GB
EGAF00006134225 fastq.gz 1.1 GB
EGAF00006134226 fastq.gz 894.8 MB
EGAF00006134227 fastq.gz 900.1 MB
EGAF00006134228 fastq.gz 1.0 GB
EGAF00006134229 fastq.gz 1.0 GB
54 Files (51.9 GB)