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Follicular lymphoma at diagnosis, treated in first line with immunochemotherapy

We performed targeted NGS in Follicular lymphoma samples at diagnosis. Explored clinico-genetic correlations and assessed four clinical or clinicogenetic risk models (FLIPI, FLIPI-2, PRIMA-IP or m7-FLIPI-molecular score) in patients with symptomatic FL who received frontline immunochemotherapy. Out of 191 patients with FL grade 1-3a, 109 were successfully genotyped. Treatment consisted on rituximab (R) plus CVP/CHOP (72.5%) or R-bendamustine (R-B) (27.5%).

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Data Access Policy for the data of the article: Prognostic scores for follicular lymphoma

DATA ACCESS AGREEMENT (DAA) These terms and conditions govern access to the managed access datasets (details of which are set out in Appendix I) to which the User Institution has requested access. The User Institution agrees to be bound by these terms and conditions. Definitions Authorized Personnel: The individuals at the User Institution to whom FUNDACIÓ INSTITUT HOSPITAL DEL MAR D’INVESTIGACIONS MÈDIQUES grants access to the Data. This includes the User, the individuals listed in Appendix II and any other individuals for whom the User Institution subsequently requests access to the Data. Details of the initial Authorized Personnel are set out in Appendix II. Data: The managed access datasets to which the User Institution has requested access. Data Producers: FUNDACIÓ INSTITUT HOSPITAL DEL MAR D’INVESTIGACIONS MÈDIQUES and the collaborators listed in Appendix I responsible for the development, organization, and oversight of these Data. External Collaborator: A collaborator of the User, working for an institution other than the User Institution. Project: The project for which the User Institution has requested access to these Data. A description of the Project must be included in Appendix II. Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. Research Participant: An individual whose data form part of these Data. Research Purposes: Shall mean research that is seeking to advance the understanding of genetics and genomics, including the treatment of disorders, and work on statistical methods that may be applied to such research. User: The principal investigator for the Project. User Institution(s): The Institution that has requested access to the Data. Please ensure that a full postal address and a valid Institutional email address are included Name: Institution’s Legal Name: Institutional Postal Address: Institutional E-mail Address: Website of the Institution: 1. The User Institution agrees to only use these Data for the purpose of the Project (described in Appendix II) and only for Research Purposes. The User Institution further agrees that it will only use these Data for Research Purposes which are within the limitations (if any) set out in Appendix I. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. Without prejudice to the generality of the foregoing, the User Institution agrees to use at least the measures set out in ANNEX II OF THE APPENDIX IV to protect these Data. The User Institution agrees that in handling this Data, the User Institution will follow an up-to-date information technology (IT) policy that must include, at a minimum, the following items: a. Logging and auditing of Access to the Data and of the computer network; b. Password protection to computer network and/or strong data encryption; c. Virus and malware protection to computers on the computer network; d. Secure backup procedure; 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The User Institution agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution shall only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorised Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 6. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 7. The User Institution agrees to acknowledge the contribution of the Data Producers in all oral and written presentations, disclosures, and Publications resulting from all analyses of the Data. The User Institution agrees to follow the Toronto Statement (http://www.nature.com/nature/journal/v461/n7261/full/461168a.html). This includes but is not limited to recognising the contribution of the Data Producers and including a proper acknowledgement in all reports or publications resulting from the use of these Data. 8. The User Institution agrees to follow the Publication Policy in Appendix III. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analysing these Data. 9. The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusion drawn directly from these Data. 10. The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 11. The User Institution will notify FUNDACIÓ INSTITUT HOSPITAL DEL MAR D’INVESTIGACIONS MÈDIQUES within 30 days of any changes or departures of Authorised Personnel. 12. The User Institution will notify FUNDACIÓ INSTITUT HOSPITAL DEL MAR D’INVESTIGACIONS MÈDIQUES prior to any significant changes to the protocol for the Project. 13. The User Institution will notify FUNDACIÓ INSTITUT HOSPITAL DEL MAR D’INVESTIGACIONS MÈDIQUES as soon as it becomes aware of a breach of the terms or conditions of this agreement. 14. FUNDACIÓ INSTITUT HOSPITAL DEL MAR D’INVESTIGACIONS MÈDIQUES may terminate this agreement by written notice to the User Institution. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the User Institution from retaining these data for archival purpose in conformity with audit or legal requirements. 15. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. As an example, this may include specific provisions relating to the Data required by Data Producers other than FUNDACIÓ INSTITUT HOSPITAL DEL MAR D’INVESTIGACIONS MÈDIQUES In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement. 16. If requested, the User Institution will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. 17. The User Institution agrees to distribute a copy of these terms to the Authorised Personnel. The User Institution will procure that the Authorised Personnel comply with the terms of this agreement. 18. This agreement (and any dispute, controversy, proceedings or claim of whatever nature arising out of this agreement or its formation) shall be construed, interpreted and governed by the laws of Spain and shall be subject to the exclusive jurisdiction of the Spanish courts. Agreed for User Institution Signature: Name: Title: Date: Principal Investigator I confirm that I have read and understood this Agreement. Signature: Name: Title: Date: APPENDIX I – DATASET DETAILS Dataset reference The dataset EGAS00001006674 consists of 109 fastq files containing the results of targeted sequencing of Follicular lymphoma samples at diagnosis. We prepared the NGS libraries using the QIAseq Targeted DNA Custom Panel REF: CDHS-10683Z-2597. Name of project that created the dataset Follicular lymphoma at diagnosis, treated in first line with immunochemotherapy Names of other data producers/collaborators Joan Gibert Fernandez (jgibert@imim.es) Maria Concepcion Fernandez Rodriguez (mconcepcionfernandezrodriguez@psmar.cat) Specific limitations on areas of research Minimum protection measures required File access: Data can be held in unencrypted files on an institutional compute system, with Unix user group read/write access for one or more appropriate groups but not Unix world read/write access behind a secure firewall. Laptops holding these data should have password protected logins and screenlocks (set to lock after 5 min of inactivity). If held on USB keys or other portable hard drives, the data must be encrypted. APPENDIX II – PROJECT DETAILS (to be completed by the Requestor or the User Institution) Details of dataset requested i.e., Study and Dataset Accession Number Brief abstract of the Project in which the Data will be used (500 words max) All Individuals who the User Institution to be named as registered users Name of Registered User Email Job Title Supervisor* APPENDIX III – PUBLICATION POLICY FUNDACIÓ INSTITUT HOSPITAL DEL MAR D’INVESTIGACIONS MÈDIQUES intend to publish the results of their analysis of this dataset and do not consider its deposition into public databases to be the equivalent of such publications. FUNDACIÓ INSTITUT HOSPITAL DEL MAR D’INVESTIGACIONS MÈDIQUES anticipate that the dataset could be useful to other qualified researchers for a variety of purposes. However, some areas of work are subject to a publication moratorium. The publication moratorium covers any publications (including oral communications) that describe the use of the dataset. For research papers, submission for publication should not occur until 12 months after these data were first made available on the relevant hosting database, unless FUNDACIÓ INSTITUT HOSPITAL DEL MAR D’INVESTIGACIONS MÈDIQUES has provided written consent to earlier submission. In any publications based on these data, please describe how the data can be accessed, including the name of the hosting database (and its accession numbers) and acknowledge its use in a form agreed by the User Institution with FUNDACIÓ INSTITUT HOSPITAL DEL MAR D’INVESTIGACIONS MÈDIQUES.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001006674 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00007294396 fastq.gz 176.3 MB
EGAF00007294397 fastq.gz 194.7 MB
EGAF00007294398 fastq.gz 200.9 MB
EGAF00007294399 fastq.gz 219.7 MB
EGAF00007294400 fastq.gz 216.5 MB
EGAF00007294401 fastq.gz 236.0 MB
EGAF00007294402 fastq.gz 494.8 MB
EGAF00007294403 fastq.gz 531.5 MB
EGAF00007294404 fastq.gz 705.5 MB
EGAF00007294405 fastq.gz 763.4 MB
EGAF00007294406 fastq.gz 558.5 MB
EGAF00007294407 fastq.gz 603.9 MB
EGAF00007294408 fastq.gz 237.1 MB
EGAF00007294409 fastq.gz 260.7 MB
EGAF00007294410 fastq.gz 662.9 MB
EGAF00007294411 fastq.gz 720.1 MB
EGAF00007294412 fastq.gz 318.2 MB
EGAF00007294413 fastq.gz 351.3 MB
EGAF00007294414 fastq.gz 197.5 MB
EGAF00007294415 fastq.gz 234.4 MB
EGAF00007294416 fastq.gz 857.8 MB
EGAF00007294417 fastq.gz 933.0 MB
EGAF00007294418 fastq.gz 363.1 MB
EGAF00007294419 fastq.gz 402.2 MB
EGAF00007294420 fastq.gz 505.6 MB
EGAF00007294421 fastq.gz 552.7 MB
EGAF00007294422 fastq.gz 772.4 MB
EGAF00007294423 fastq.gz 836.7 MB
EGAF00007294424 fastq.gz 172.6 MB
EGAF00007294425 fastq.gz 192.4 MB
EGAF00007294426 fastq.gz 749.7 MB
EGAF00007294427 fastq.gz 834.2 MB
EGAF00007294428 fastq.gz 256.2 MB
EGAF00007294429 fastq.gz 279.7 MB
EGAF00007294430 fastq.gz 305.1 MB
EGAF00007294431 fastq.gz 333.4 MB
EGAF00007294432 fastq.gz 981.7 MB
EGAF00007294433 fastq.gz 1.1 GB
EGAF00007294434 fastq.gz 204.1 MB
EGAF00007294435 fastq.gz 224.3 MB
EGAF00007294436 fastq.gz 355.8 MB
EGAF00007294437 fastq.gz 389.4 MB
EGAF00007294438 fastq.gz 518.1 MB
EGAF00007294439 fastq.gz 565.6 MB
EGAF00007294440 fastq.gz 264.3 MB
EGAF00007294441 fastq.gz 289.5 MB
EGAF00007294442 fastq.gz 461.4 MB
EGAF00007294443 fastq.gz 501.8 MB
EGAF00007294444 fastq.gz 93.9 MB
EGAF00007294445 fastq.gz 103.2 MB
EGAF00007294446 fastq.gz 350.7 MB
EGAF00007294447 fastq.gz 388.6 MB
EGAF00007294448 fastq.gz 261.2 MB
EGAF00007294449 fastq.gz 286.8 MB
EGAF00007294450 fastq.gz 1.7 GB
EGAF00007294451 fastq.gz 1.9 GB
EGAF00007294452 fastq.gz 203.1 MB
EGAF00007294453 fastq.gz 226.3 MB
EGAF00007294454 fastq.gz 423.2 MB
EGAF00007294455 fastq.gz 469.6 MB
EGAF00007294456 fastq.gz 1.3 GB
EGAF00007294457 fastq.gz 1.4 GB
EGAF00007294458 fastq.gz 226.2 MB
EGAF00007294459 fastq.gz 249.0 MB
EGAF00007294460 fastq.gz 96.8 MB
EGAF00007294461 fastq.gz 108.1 MB
EGAF00007294462 fastq.gz 457.6 MB
EGAF00007294463 fastq.gz 512.6 MB
EGAF00007294464 fastq.gz 247.0 MB
EGAF00007294465 fastq.gz 273.2 MB
EGAF00007294466 fastq.gz 840.9 MB
EGAF00007294467 fastq.gz 928.8 MB
EGAF00007294468 fastq.gz 101.4 MB
EGAF00007294469 fastq.gz 116.1 MB
EGAF00007294470 fastq.gz 272.2 MB
EGAF00007294471 fastq.gz 298.7 MB
EGAF00007294472 fastq.gz 292.0 MB
EGAF00007294473 fastq.gz 317.3 MB
EGAF00007294474 fastq.gz 149.8 MB
EGAF00007294475 fastq.gz 160.0 MB
EGAF00007294476 fastq.gz 526.4 MB
EGAF00007294477 fastq.gz 583.1 MB
EGAF00007294478 fastq.gz 196.8 MB
EGAF00007294479 fastq.gz 215.9 MB
EGAF00007294480 fastq.gz 216.1 MB
EGAF00007294481 fastq.gz 239.4 MB
EGAF00007294482 fastq.gz 402.3 MB
EGAF00007294483 fastq.gz 445.1 MB
EGAF00007294484 fastq.gz 445.6 MB
EGAF00007294485 fastq.gz 488.9 MB
EGAF00007294486 fastq.gz 194.6 MB
EGAF00007294487 fastq.gz 213.4 MB
EGAF00007294488 fastq.gz 333.8 MB
EGAF00007294489 fastq.gz 368.0 MB
EGAF00007294490 fastq.gz 255.8 MB
EGAF00007294491 fastq.gz 285.2 MB
EGAF00007294492 fastq.gz 5.3 GB
EGAF00007294493 fastq.gz 5.8 GB
EGAF00007294494 fastq.gz 690.8 MB
EGAF00007294495 fastq.gz 727.3 MB
EGAF00007294496 fastq.gz 843.5 MB
EGAF00007294497 fastq.gz 961.6 MB
EGAF00007294498 fastq.gz 550.3 MB
EGAF00007294499 fastq.gz 601.6 MB
EGAF00007294500 fastq.gz 898.3 MB
EGAF00007294501 fastq.gz 988.3 MB
EGAF00007294502 fastq.gz 1.0 GB
EGAF00007294503 fastq.gz 1.1 GB
EGAF00007294504 fastq.gz 959.6 MB
EGAF00007294505 fastq.gz 1.1 GB
EGAF00007294506 fastq.gz 862.5 MB
EGAF00007294507 fastq.gz 965.8 MB
EGAF00007294508 fastq.gz 1.0 GB
EGAF00007294509 fastq.gz 1.1 GB
EGAF00007294510 fastq.gz 873.1 MB
EGAF00007294511 fastq.gz 945.5 MB
EGAF00007294512 fastq.gz 785.9 MB
EGAF00007294513 fastq.gz 881.8 MB
EGAF00007294514 fastq.gz 643.7 MB
EGAF00007294515 fastq.gz 715.7 MB
EGAF00007294516 fastq.gz 880.0 MB
EGAF00007294517 fastq.gz 999.4 MB
EGAF00007294518 fastq.gz 678.2 MB
EGAF00007294519 fastq.gz 744.4 MB
EGAF00007294520 fastq.gz 657.5 MB
EGAF00007294521 fastq.gz 759.1 MB
EGAF00007294522 fastq.gz 869.0 MB
EGAF00007294523 fastq.gz 953.0 MB
EGAF00007294524 fastq.gz 775.5 MB
EGAF00007294525 fastq.gz 854.6 MB
EGAF00007294526 fastq.gz 669.2 MB
EGAF00007294527 fastq.gz 734.9 MB
EGAF00007294528 fastq.gz 947.2 MB
EGAF00007294529 fastq.gz 1.0 GB
EGAF00007294530 fastq.gz 846.2 MB
EGAF00007294531 fastq.gz 975.5 MB
EGAF00007294532 fastq.gz 967.8 MB
EGAF00007294533 fastq.gz 1.1 GB
EGAF00007294534 fastq.gz 689.2 MB
EGAF00007294535 fastq.gz 760.4 MB
EGAF00007294536 fastq.gz 507.4 MB
EGAF00007294537 fastq.gz 555.8 MB
EGAF00007294538 fastq.gz 965.7 MB
EGAF00007294539 fastq.gz 1.0 GB
EGAF00007294540 fastq.gz 2.0 GB
EGAF00007294541 fastq.gz 2.2 GB
EGAF00007294542 fastq.gz 878.9 MB
EGAF00007294543 fastq.gz 989.0 MB
EGAF00007294544 fastq.gz 1.1 GB
EGAF00007294545 fastq.gz 1.2 GB
EGAF00007294546 fastq.gz 925.3 MB
EGAF00007294547 fastq.gz 1.0 GB
EGAF00007294548 fastq.gz 820.2 MB
EGAF00007294549 fastq.gz 922.2 MB
EGAF00007294550 fastq.gz 251.9 MB
EGAF00007294551 fastq.gz 278.2 MB
EGAF00007294552 fastq.gz 250.9 MB
EGAF00007294553 fastq.gz 273.8 MB
EGAF00007294554 fastq.gz 140.1 MB
EGAF00007294555 fastq.gz 158.6 MB
EGAF00007294556 fastq.gz 786.6 MB
EGAF00007294557 fastq.gz 881.5 MB
EGAF00007294558 fastq.gz 272.7 MB
EGAF00007294559 fastq.gz 314.0 MB
EGAF00007294560 fastq.gz 175.5 MB
EGAF00007294561 fastq.gz 192.6 MB
EGAF00007294562 fastq.gz 304.1 MB
EGAF00007294563 fastq.gz 350.0 MB
EGAF00007294564 fastq.gz 763.2 MB
EGAF00007294565 fastq.gz 876.8 MB
EGAF00007294566 fastq.gz 640.8 MB
EGAF00007294567 fastq.gz 742.5 MB
EGAF00007294568 fastq.gz 205.8 MB
EGAF00007294569 fastq.gz 232.5 MB
EGAF00007294570 fastq.gz 240.8 MB
EGAF00007294571 fastq.gz 284.2 MB
EGAF00007294572 fastq.gz 21.3 MB
EGAF00007294573 fastq.gz 23.9 MB
EGAF00007294574 fastq.gz 534.7 MB
EGAF00007294575 fastq.gz 569.6 MB
EGAF00007294576 fastq.gz 691.6 MB
EGAF00007294577 fastq.gz 798.1 MB
EGAF00007294578 fastq.gz 738.7 MB
EGAF00007294579 fastq.gz 817.9 MB
EGAF00007294580 fastq.gz 580.6 MB
EGAF00007294581 fastq.gz 650.2 MB
EGAF00007294582 fastq.gz 553.3 MB
EGAF00007294583 fastq.gz 632.4 MB
EGAF00007294584 fastq.gz 507.7 MB
EGAF00007294585 fastq.gz 586.3 MB
EGAF00007294586 fastq.gz 510.5 MB
EGAF00007294587 fastq.gz 587.4 MB
EGAF00007294588 fastq.gz 419.8 MB
EGAF00007294589 fastq.gz 480.7 MB
EGAF00007294590 fastq.gz 281.9 MB
EGAF00007294591 fastq.gz 296.2 MB
EGAF00007294592 fastq.gz 537.8 MB
EGAF00007294593 fastq.gz 607.9 MB
EGAF00007294594 fastq.gz 365.9 MB
EGAF00007294595 fastq.gz 414.2 MB
EGAF00007294596 fastq.gz 485.6 MB
EGAF00007294597 fastq.gz 533.7 MB
EGAF00007294598 fastq.gz 476.1 MB
EGAF00007294599 fastq.gz 527.0 MB
EGAF00007294600 fastq.gz 425.7 MB
EGAF00007294601 fastq.gz 478.9 MB
EGAF00007294602 fastq.gz 353.8 MB
EGAF00007294603 fastq.gz 397.7 MB
EGAF00007294604 fastq.gz 448.9 MB
EGAF00007294605 fastq.gz 502.4 MB
EGAF00007294606 fastq.gz 2.6 GB
EGAF00007294607 fastq.gz 2.9 GB
EGAF00007294608 fastq.gz 111.0 MB
EGAF00007294609 fastq.gz 125.3 MB
EGAF00007294610 fastq.gz 380.4 MB
EGAF00007294611 fastq.gz 435.6 MB
EGAF00007294612 fastq.gz 749.7 MB
EGAF00007294613 fastq.gz 816.5 MB
218 Files (138.1 GB)