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Distinct embryonic phylogenies and driver events of infant Wilms tumor - DNA

Cancers of adults typically arise through progressive rounds of clonal diversification and intratumoral selective sweeps which generate a long mutational trunk with shorter subclonal branches. Here, we investigated whether tumors of young children exhibit the same phylogenetic configuration. We studied three infants, including two newborns, with the childhood kidney cancer, Wilms tumour, through whole genome sequencing of bulk tissues, of single cell derived organoids, and of microdissections. All three cancers exhibited unusual driver events, with tumours of newborns harbouring FOXR2 rearrangements, delineating a distinct variant of Wilms tumour. Phylogenetic analyses suggest that tumors were seeded in an early, possibly confined window of development. Unusually, following seeding there was extensive polyclonal diversification with little evidence of clonal sweeps, leading to a distinct phylogenetic configuration more reminiscent of normal tissues rather than of adult cancers. These findings indicate that some childhood cancers may diversify via unorthodox phylogenetic pathways.

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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001002692 Cancer Genomics
EGAS00001004237 Cancer Genomics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00002057441 cram 2.1 GB
EGAF00002057442 cram 2.3 GB
EGAF00002057443 cram 2.1 GB
EGAF00002057444 cram 2.3 GB
EGAF00002057445 cram 2.2 GB
EGAF00002057446 cram 2.1 GB
EGAF00002057447 cram 2.3 GB
EGAF00002057460 cram 1.9 GB
EGAF00002057461 cram 2.3 GB
EGAF00002057462 cram 2.0 GB
EGAF00002057463 cram 2.2 GB
EGAF00002057464 cram 2.2 GB
EGAF00002057465 cram 2.2 GB
EGAF00002057466 cram 2.3 GB
EGAF00002057467 cram 2.3 GB
EGAF00002057468 cram 2.4 GB
EGAF00002057469 cram 2.1 GB
EGAF00002057470 cram 2.3 GB
EGAF00002057471 cram 2.1 GB
EGAF00002057472 cram 2.3 GB
EGAF00002057473 cram 2.2 GB
EGAF00002057474 cram 2.1 GB
EGAF00002057475 cram 2.3 GB
EGAF00002057476 cram 1.9 GB
EGAF00002057477 cram 2.3 GB
EGAF00002057478 cram 2.0 GB
EGAF00002057479 cram 2.2 GB
EGAF00002057480 cram 2.1 GB
EGAF00002057481 cram 2.1 GB
EGAF00002057482 cram 2.3 GB
EGAF00002057483 cram 2.3 GB
EGAF00002057484 cram 2.3 GB
EGAF00002057485 cram 2.1 GB
EGAF00002057486 cram 2.3 GB
EGAF00002057487 cram 2.1 GB
EGAF00002057488 cram 2.4 GB
EGAF00002057489 cram 2.3 GB
EGAF00002057490 cram 2.1 GB
EGAF00002057491 cram 2.4 GB
EGAF00002057492 cram 2.0 GB
EGAF00002057493 cram 2.3 GB
EGAF00002057494 cram 2.1 GB
EGAF00002057495 cram 2.2 GB
EGAF00002057496 cram 2.2 GB
EGAF00002057497 cram 2.2 GB
EGAF00002057498 cram 2.3 GB
EGAF00002057499 cram 2.3 GB
EGAF00002057500 cram 2.4 GB
EGAF00002057501 cram 2.1 GB
EGAF00002057502 cram 2.3 GB
EGAF00002057503 cram 2.1 GB
EGAF00002057504 cram 2.3 GB
EGAF00002057505 cram 2.2 GB
EGAF00002057506 cram 2.1 GB
EGAF00002057507 cram 2.3 GB
EGAF00002057508 cram 1.9 GB
EGAF00002057509 cram 2.3 GB
EGAF00002057510 cram 2.0 GB
EGAF00002057511 cram 2.2 GB
EGAF00002057512 cram 2.1 GB
EGAF00002057513 cram 2.1 GB
EGAF00002057514 cram 2.3 GB
EGAF00002057515 cram 2.3 GB
EGAF00002057516 cram 2.4 GB
EGAF00002057517 cram 2.2 GB
EGAF00002057518 cram 2.3 GB
EGAF00002057519 cram 2.1 GB
EGAF00002057520 cram 2.4 GB
EGAF00002057521 cram 2.3 GB
EGAF00002057522 cram 2.1 GB
EGAF00002057523 cram 2.4 GB
EGAF00002057524 cram 2.0 GB
EGAF00002057525 cram 2.3 GB
EGAF00002057526 cram 2.1 GB
EGAF00002057527 cram 2.2 GB
EGAF00002057528 cram 2.2 GB
EGAF00002057529 cram 2.2 GB
EGAF00002057530 cram 2.3 GB
EGAF00002057531 cram 2.3 GB
EGAF00002057532 cram 2.4 GB
EGAF00002057533 cram 2.1 GB
EGAF00002057534 cram 2.3 GB
EGAF00002057535 cram 2.1 GB
EGAF00002057536 cram 2.3 GB
EGAF00002057537 cram 2.2 GB
EGAF00002057538 cram 2.1 GB
EGAF00002057539 cram 2.3 GB
EGAF00002057540 cram 1.9 GB
EGAF00002057541 cram 2.3 GB
EGAF00002057542 cram 2.0 GB
EGAF00002057543 cram 2.2 GB
EGAF00002057544 cram 2.1 GB
EGAF00002057545 cram 2.1 GB
EGAF00002057546 cram 2.3 GB
EGAF00002057547 cram 2.3 GB
EGAF00002057548 cram 2.4 GB
EGAF00002057549 cram 2.2 GB
EGAF00002057550 cram 2.3 GB
EGAF00002057551 cram 2.2 GB
EGAF00002057552 cram 2.4 GB
EGAF00002057553 cram 2.3 GB
EGAF00002057554 cram 2.2 GB
EGAF00002057555 cram 2.4 GB
EGAF00002057556 cram 2.0 GB
EGAF00002057557 cram 2.3 GB
EGAF00002057558 cram 2.1 GB
EGAF00002057559 cram 2.3 GB
EGAF00002057560 cram 2.2 GB
EGAF00002057561 cram 2.2 GB
EGAF00002057562 cram 2.3 GB
EGAF00002057563 cram 2.4 GB
EGAF00002057564 cram 2.4 GB
EGAF00002057565 cram 2.1 GB
EGAF00002057566 cram 2.3 GB
EGAF00002057567 cram 2.1 GB
EGAF00002057568 cram 2.3 GB
EGAF00002057569 cram 2.2 GB
EGAF00002057570 cram 2.1 GB
EGAF00002057571 cram 2.3 GB
EGAF00002057572 cram 1.9 GB
EGAF00002057573 cram 2.2 GB
EGAF00002057574 cram 2.0 GB
EGAF00002057575 cram 2.2 GB
EGAF00002057576 cram 2.1 GB
EGAF00002057577 cram 2.1 GB
EGAF00002057578 cram 2.2 GB
EGAF00002057579 cram 2.3 GB
EGAF00002057580 cram 2.3 GB
EGAF00002278337 cram 16.9 GB
EGAF00002278338 cram 18.6 GB
EGAF00002278339 cram 16.6 GB
EGAF00002278340 cram 18.2 GB
EGAF00002278341 cram 16.8 GB
EGAF00002278342 cram 18.6 GB
EGAF00002467258 cram 28.3 GB
EGAF00002467259 cram 28.6 GB
EGAF00003441605 cram 11.4 GB
EGAF00003441664 cram 10.3 GB
EGAF00003441665 cram 11.3 GB
EGAF00003441666 cram 11.4 GB
EGAF00003441667 cram 10.6 GB
EGAF00003441668 cram 11.6 GB
EGAF00007829945 cram 20.1 GB
EGAF00007829946 cram 21.8 GB
EGAF00007829947 cram 21.9 GB
EGAF00007829948 cram 17.8 GB
EGAF00007829949 cram 19.0 GB
EGAF00007829950 cram 22.0 GB
EGAF00007829951 cram 24.0 GB
EGAF00007829952 cram 15.6 GB
EGAF00007829953 cram 15.6 GB
EGAF00007829954 cram 16.1 GB
EGAF00007829955 cram 14.4 GB
EGAF00007829956 cram 15.0 GB
EGAF00007829957 cram 19.2 GB
EGAF00007829958 cram 16.0 GB
EGAF00007829959 cram 14.2 GB
EGAF00007829960 cram 160.4 GB
EGAF00007829961 cram 27.8 GB
EGAF00007829962 cram 31.8 GB
EGAF00007829963 cram 29.3 GB
EGAF00007829964 cram 32.1 GB
EGAF00007829965 cram 32.2 GB
EGAF00007830002 cram 44.7 GB
EGAF00007830003 cram 33.0 GB
EGAF00007830004 cram 33.3 GB
EGAF00007830005 cram 44.5 GB
EGAF00007830006 cram 33.0 GB
EGAF00007830007 cram 33.2 GB
EGAF00007830011 cram 32.9 GB
EGAF00007830012 cram 53.0 GB
EGAF00007830013 cram 50.7 GB
EGAF00007830014 cram 43.9 GB
EGAF00007830015 cram 51.5 GB
EGAF00007830017 cram 27.1 GB
EGAF00007830018 cram 21.7 GB
EGAF00007830019 cram 24.0 GB
EGAF00007830020 cram 20.5 GB
EGAF00007830021 cram 17.8 GB
EGAF00007830022 cram 26.2 GB
EGAF00007830023 cram 22.2 GB
EGAF00007830024 cram 18.8 GB
EGAF00007830025 cram 19.8 GB
EGAF00007830026 cram 24.3 GB
EGAF00007830027 cram 24.6 GB
EGAF00007830028 cram 15.6 GB
EGAF00007830029 cram 20.1 GB
EGAF00007830030 cram 30.0 GB
EGAF00007830031 cram 23.9 GB
EGAF00007830032 cram 30.8 GB
EGAF00007830033 cram 18.4 GB
EGAF00007830034 cram 33.5 GB
EGAF00007830035 cram 26.3 GB
EGAF00007830036 cram 42.2 GB
EGAF00007830037 cram 40.9 GB
EGAF00007830038 cram 25.1 GB
EGAF00007830039 cram 19.3 GB
EGAF00007830040 cram 36.1 GB
EGAF00007830041 cram 47.9 GB
EGAF00007830042 cram 72.7 GB
EGAF00007830043 cram 55.6 GB
201 Files (2.3 TB)