About file location

As the EGA is co-managed by the EMBL-EBI and CRG, files could be located in the UK and/or Spain, as indicated by their respective flags.

Alternatively, files could be located in one of the international Federated EGA nodes, as indicated next to the node's flag.
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NEC

This multi-centre, non-randomized, open-label, phase II trial (NCT03016338), assessed niraparib monotherapy (cohort 1, C1), or niraparib and dostarlimab (cohort 2, C2) in patients with recurrent serous or endometrioid endometrial carcinoma. The primary endpoint was clinical benefit rate (CBR). Secondary outcomes were safety and objective response rate (ORR). Translational research was an exploratory outcome. Potential biomarkers were evaluated in archival tissue by immunohistochemistry and next generation sequencing panel. Feasibility of liquid biopsy by ctDNA was assessed.

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Access to data generated by UHN is made available by completing the data access agreement for review by the data access committee and will be granted to qualified investigators for appropriate use.

DATA ACCESS AGREEMENT These terms and conditions govern access to the managed access datasets (details of which are set out in Appendix I) to which the User Institution has requested access. The User Institution agrees to be bound by these terms and conditions. Definitions Authorised Personnel: The individuals at the User Institution to whom the Data Access Committee (DAC) grants access to the Data. This includes the User, the individuals listed in Appendix II and any other individuals for whom the User Institution subsequently requests access to the Data. Details of the initial Authorised Personnel are set out in Appendix II. Data: The managed access datasets to which the User Institution has requested access. Data Producers: The Principal Investigator and the collaborators listed in Appendix I responsible for the development, organisation, and oversight of these Data. External Collaborator: A collaborator of the User, working for an institution other than the User Institution. Project: The project for which the User Institution has requested access to these Data. A description of the Project is set out in Appendix II. Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. Research Participant: An individual whose data form part of these Data. Research Purposes: Shall mean research that is seeking to advance the understanding of genetics and genomics, including the treatment of disorders, and work on statistical methods that may be applied to such research. User: The principal investigator for the Project. User Institution(s): The Institution that has requested access to the Data. University Health Network: The University Health Network (UHN) is the largest clinical and research hospital in Canada. UHN is affiliated with the University of Toronto and is a member of the Toronto Academic Health Science Network. 1. The User Institution agrees to only use these Data for the purpose of the Project (described in Appendix II) and only for Research Purposes. The User Institution further agrees that it will only use these Data for Research Purposes which are within the limitations (if any) set out in Appendix I. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. Without prejudice to the generality of the foregoing, the User Institution agrees to use at least the measures set out in Appendix I to protect these Data. 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The User Institution agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorised Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 6. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 7. The User Institution agrees to follow the Fort Lauderdale Guidelines (http://www.wellcome.ac.uk/stellent/groups/corporatesite/@policy_communications/documents/web_document/wtd003207.pdf ) and the Toronto Statement (http://www.nature.com/nature/journal/v461/n7261/full/461168a.html). This includes but is not limited to recognising the contribution of the Data Producers and including a proper acknowledgement in all reports or publications resulting from the use of these Data. 8. The User Institution agrees to follow the Publication Policy in Appendix III. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analysing these Data. 9. The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusion drawn directly from these Data. 10. The User Institution can elect to perform further research that would add intellectual and resource capital to these data and decide to obtain intellectual property rights on these downstream discoveries. In this case, the User Institution agrees to implement licensing policies that will not obstruct further research and to follow the U.S. National Institutes of Health Best Practices for the Licensing of Genomic Inventions (2005) (https://www.icgc.org/files/daco/NIH_BestPracticesLicensingGenomicInventions_2005_en.pdf ) in conformity with the Organisation for Economic Co-operation and Development Guidelines for the Licensing of the Genetic Inventions (2006) (http://www.oecd.org/science/biotech/36198812.pdf ). 11. The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 12. The User Institution will notify the DAC within 30 days of any changes or departures of Authorised Personnel. 13. The User Institution will notify the DAC prior to any significant changes to the protocol for the Project. 14. The User Institution will notify the DAC as soon as it becomes aware of a breach of the terms or conditions of this agreement. 15. The DAC may terminate this agreement by written notice to the User Institution. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the User Institution from retaining these data for archival purpose in conformity with audit or legal requirements. 16. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement. 17. If requested, the User Institution will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. 18. The User Institution agrees to distribute a copy of these terms to the Authorised Personnel. The User Institution will procure that the Authorised Personnel comply with the terms of this agreement. 19. This agreement (and any dispute, controversy, proceedings or claim of whatever nature arising out of this agreement or its formation) shall be construed, interpreted and governed by the laws of the province of Ontario and PHIPA. Agreed for User Institution Signature: Name: Title: Date: Principal Investigator I confirm that I have read and understood this Agreement. Signature: Name: Title: Date: Agreed for The Data Access Committee Signature: Name: Title: Date: APPENDIX I – DATASET DETAILS APPENDIX II ––PROJECT DETAILS APPENDIX III –– PUBLICATION POLICY

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001007013 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Quality Report
Located in
i
EGAF00007940535 fastq.gz 3.8 GB Report
EGAF00007940536 fastq.gz 3.9 GB Report
EGAF00007940537 fastq.gz 1.4 GB Report
EGAF00007940538 fastq.gz 1.4 GB Report
EGAF00007940539 fastq.gz 3.9 GB Report
EGAF00007940540 fastq.gz 4.0 GB Report
EGAF00007940541 fastq.gz 1.4 GB Report
EGAF00007940542 fastq.gz 1.4 GB Report
EGAF00007940543 fastq.gz 1.3 GB Report
EGAF00007940544 fastq.gz 1.3 GB Report
EGAF00007940545 fastq.gz 4.7 GB Report
EGAF00007940546 fastq.gz 4.9 GB Report
EGAF00007940547 fastq.gz 3.1 GB Report
EGAF00007940548 fastq.gz 3.3 GB Report
EGAF00007940549 fastq.gz 1.5 GB Report
EGAF00007940550 fastq.gz 1.6 GB Report
EGAF00007940551 fastq.gz 3.7 GB Report
EGAF00007940552 fastq.gz 4.0 GB Report
EGAF00007940553 fastq.gz 1.5 GB Report
EGAF00007940554 fastq.gz 1.6 GB Report
EGAF00007940555 fastq.gz 3.7 GB Report
EGAF00007940556 fastq.gz 3.9 GB Report
EGAF00007940557 fastq.gz 3.3 GB Report
EGAF00007940558 fastq.gz 3.5 GB Report
EGAF00007940559 fastq.gz 1.4 GB Report
EGAF00007940560 fastq.gz 1.4 GB Report
EGAF00007940561 fastq.gz 5.6 GB Report
EGAF00007940562 fastq.gz 5.9 GB Report
EGAF00007940563 fastq.gz 1.4 GB Report
EGAF00007940564 fastq.gz 1.4 GB Report
EGAF00007940565 fastq.gz 3.1 GB Report
EGAF00007940566 fastq.gz 3.2 GB Report
EGAF00007940567 fastq.gz 1.0 GB Report
EGAF00007940568 fastq.gz 152.1 MB Report
EGAF00007940569 fastq.gz 1.0 GB Report
EGAF00007940570 fastq.gz 1.5 GB Report
EGAF00007940571 fastq.gz 1.5 GB Report
EGAF00007940572 fastq.gz 1.1 GB Report
EGAF00007940573 fastq.gz 161.8 MB Report
EGAF00007940574 fastq.gz 1.1 GB Report
EGAF00007940575 fastq.gz 271.8 MB Report
EGAF00007940576 fastq.gz 1.1 GB Report
EGAF00007940577 fastq.gz 158.8 MB Report
EGAF00007940578 fastq.gz 1.0 GB Report
EGAF00007940579 fastq.gz 157.6 MB Report
EGAF00007940580 fastq.gz 1.1 GB Report
EGAF00007940581 fastq.gz 1.5 GB Report
EGAF00007940582 fastq.gz 1.5 GB Report
EGAF00007940583 fastq.gz 3.6 GB Report
EGAF00007940584 fastq.gz 3.7 GB Report
EGAF00007940585 fastq.gz 1.5 GB Report
EGAF00007940586 fastq.gz 1.5 GB Report
EGAF00007940587 fastq.gz 1.2 GB Report
EGAF00007940588 fastq.gz 177.8 MB Report
EGAF00007940589 fastq.gz 1.2 GB Report
EGAF00007940590 fastq.gz 4.0 GB Report
EGAF00007940591 fastq.gz 4.2 GB Report
EGAF00007940592 fastq.gz 1.0 GB Report
EGAF00007940593 fastq.gz 154.1 MB Report
EGAF00007940594 fastq.gz 1.1 GB Report
EGAF00007940595 fastq.gz 1.5 GB Report
EGAF00007940596 fastq.gz 1.5 GB Report
EGAF00007940597 fastq.gz 5.0 GB Report
EGAF00007940598 fastq.gz 5.3 GB Report
EGAF00007940599 fastq.gz 4.1 GB Report
EGAF00007940600 fastq.gz 4.3 GB Report
EGAF00007940601 fastq.gz 1.6 GB Report
EGAF00007940602 fastq.gz 1.6 GB Report
EGAF00007940603 fastq.gz 3.5 GB Report
EGAF00007940604 fastq.gz 3.8 GB Report
EGAF00007940605 fastq.gz 1.4 GB Report
EGAF00007940606 fastq.gz 1.4 GB Report
EGAF00007940607 fastq.gz 3.4 GB Report
EGAF00007940608 fastq.gz 3.7 GB Report
EGAF00007940609 fastq.gz 1.6 GB Report
EGAF00007940610 fastq.gz 1.6 GB Report
EGAF00007940611 fastq.gz 1.6 GB Report
EGAF00007940612 fastq.gz 1.8 GB Report
EGAF00007940613 fastq.gz 1.9 GB Report
EGAF00007940614 fastq.gz 2.0 GB Report
EGAF00007940615 fastq.gz 4.3 GB Report
EGAF00007940616 fastq.gz 4.4 GB Report
EGAF00007940617 fastq.gz 1.6 GB Report
EGAF00007940618 fastq.gz 1.6 GB Report
EGAF00007940619 fastq.gz 1.8 GB Report
EGAF00007940620 fastq.gz 1.9 GB Report
EGAF00007940621 fastq.gz 1.5 GB Report
EGAF00007940622 fastq.gz 1.6 GB Report
EGAF00007940623 fastq.gz 1.5 GB Report
EGAF00007940624 fastq.gz 1.5 GB Report
EGAF00007940625 fastq.gz 1.5 GB Report
EGAF00007940626 fastq.gz 1.6 GB Report
EGAF00007940627 fastq.gz 1.7 GB Report
EGAF00007940628 fastq.gz 1.8 GB Report
EGAF00007940629 fastq.gz 1.5 GB Report
EGAF00007940630 fastq.gz 1.6 GB Report
EGAF00007940631 fastq.gz 1.0 GB Report
EGAF00007940632 fastq.gz 153.3 MB Report
EGAF00007940633 fastq.gz 1.0 GB Report
EGAF00007940634 fastq.gz 1.1 GB Report
EGAF00007940635 fastq.gz 162.6 MB Report
EGAF00007940636 fastq.gz 1.1 GB Report
EGAF00007940637 fastq.gz 918.7 MB Report
EGAF00007940638 fastq.gz 143.4 MB Report
EGAF00007940639 fastq.gz 978.3 MB Report
EGAF00007940640 fastq.gz 1.5 GB Report
EGAF00007940641 fastq.gz 1.5 GB Report
EGAF00007940642 fastq.gz 1.5 GB Report
EGAF00007940643 fastq.gz 1.5 GB Report
EGAF00007940644 fastq.gz 1.7 GB Report
EGAF00007940645 fastq.gz 1.8 GB Report
EGAF00007940646 fastq.gz 1.5 GB Report
EGAF00007940647 fastq.gz 1.5 GB Report
EGAF00007940648 fastq.gz 1.5 GB Report
EGAF00007940649 fastq.gz 1.5 GB Report
EGAF00007940650 fastq.gz 1.4 GB Report
EGAF00007940651 fastq.gz 1.4 GB Report
EGAF00007940652 fastq.gz 3.7 GB Report
EGAF00007940653 fastq.gz 4.1 GB Report
EGAF00007940654 fastq.gz 956.5 MB Report
EGAF00007940655 fastq.gz 142.2 MB Report
EGAF00007940656 fastq.gz 4.6 GB Report
EGAF00007940657 fastq.gz 4.9 GB Report
EGAF00007940658 fastq.gz 1.4 GB Report
EGAF00007940659 fastq.gz 1.4 GB Report
EGAF00007940660 fastq.gz 1.3 GB Report
EGAF00007940661 fastq.gz 1.3 GB Report
EGAF00007940662 fastq.gz 1.6 GB Report
EGAF00007940663 fastq.gz 1.6 GB Report
EGAF00007940664 fastq.gz 1.5 GB Report
EGAF00007940665 fastq.gz 1.5 GB Report
EGAF00007940666 fastq.gz 1.4 GB Report
EGAF00007940667 fastq.gz 1.4 GB Report
EGAF00007940668 fastq.gz 808.2 MB Report
EGAF00007940669 fastq.gz 131.2 MB Report
EGAF00007940670 fastq.gz 852.6 MB Report
EGAF00007940671 fastq.gz 1.0 GB Report
EGAF00007940672 fastq.gz 153.7 MB Report
EGAF00007940673 fastq.gz 1.0 GB Report
EGAF00007940674 fastq.gz 3.1 GB Report
EGAF00007940675 fastq.gz 3.3 GB Report
EGAF00007940676 fastq.gz 801.6 MB Report
EGAF00007940677 fastq.gz 120.4 MB Report
EGAF00007940678 fastq.gz 823.8 MB Report
EGAF00007940679 fastq.gz 1.4 GB Report
EGAF00007940680 fastq.gz 1.4 GB Report
EGAF00007940681 fastq.gz 936.6 MB Report
EGAF00007940682 fastq.gz 141.6 MB Report
EGAF00007940683 fastq.gz 963.2 MB Report
EGAF00007940684 fastq.gz 984.1 MB Report
EGAF00007940685 fastq.gz 150.2 MB Report
EGAF00007940686 fastq.gz 1.0 GB Report
EGAF00007940687 fastq.gz 1.1 GB Report
EGAF00007940688 fastq.gz 171.9 MB Report
EGAF00007940689 fastq.gz 1.2 GB Report
155 Files (293.2 GB)